Ultrasonic imaging of textured alumina

Ultrasonic images representing the bulk attenuation and velocity of a set of alumina samples were obtained by a pulse-echo contact scanning technique. The samples were taken from larger bodies that were chemically similar but were processed by extrusion or isostatic processing. The crack growth resistance and fracture toughness of the larger bodies were found to vary with processing method and test orientation. The results presented here demonstrate that differences in texture that contribute to variations in structural performance can be revealed by analytic ultrasonic techniques

The Carboxyl-Terminal Amino Acids Render Pro-Human LC3B Migration Similar to Lipidated LC3B in SDS-PAGE

LC3 is widely used marker for macroautophagy assays. After translation pro-LC3 is processed by Atg4 to expose C-terminal glycine residue for downstream conjugation reactions to accomplish the conversion of LC3-I to LC3-II. SDS-PAGE based Western blot (Wb) is generally utilized to quantify LC3-II levels where the LC3-I band migrates slower than LC3-II. We found that pro-human LC3B migrated at similar rate as LC3B-II in SDS-PAGE. The carboxyl-terminal five amino acids, particularly Lysine122 and Leucine123 of human LC3B play a major role in the faster migration of unprocessed LC3B, rendering it indistinguishable from LC3B-II in Wb assays. The unique faster migration of unprocessed LC3B than LC3B-I is also revealed in mouse LC3B, rat LC3B and rat LC3 but not in human LC3C. Our findings for the first time define pro-LC3 migration patterns for LC3 family member from human, mouse and rat species in SDS-PAGE. These findings provide a reference for pro-LC3 band patterns when Atg4 function is inhibited. © 2013 Wang et al

Review and statistical analysis of the ultrasonic velocity method for estimating the porosity fraction in polycrystalline materials

A review and statistical analysis of the ultrasonic velocity method for estimating the porosity fraction in polycrystalline materials is presented. Initially, a semi-empirical model is developed showing the origin of the linear relationship between ultrasonic velocity and porosity fraction. Then, from a compilation of data produced by many researchers, scatter plots of velocity versus percent porosity data are shown for Al2O3, MgO, porcelain-based ceramics, PZT, SiC, Si3N4, steel, tungsten, UO2,(U0.30Pu0.70)C, and YBa2Cu3O(7-x). Linear regression analysis produced predicted slope, intercept, correlation coefficient, level of significance, and confidence interval statistics for the data. Velocity values predicted from regression analysis for fully-dense materials are in good agreement with those calculated from elastic properties

Interfacing Laboratory Instruments to Multiuser, Virtual Memory Computers

Computers based on virtual memory, multiuser architecture have recently become economically available to medium sized research groups (about 25 members). These new computers offer advantages to the experimentalist, though acceptance has been sometimes limited. One of the most important advantages of a virtual memory machine is the capability of fast access to arrays having dimensions greater than 64 kbytes. Arrays larger than 64 kbytes were available on some older computers based on physical memory. The access time to the memory beyond 64 kbytes is extremely slow for these systems. Fast access to large arrays is particularly important now where large data sets are required for research system

An investigation of gender, perceived gender-barriers to a future occupation, and academic achievement among delinquent adolescents

The current study assesses perceptions of gender-related barriers to a future occupation and its association with academic achievement among delinquent adolescents aged 12-19 years old. It was hypothesized that the perception of gender related barriers to a future occupation would have similar effects on male and female adolescents\u27 academic achievement. Data included self-reported perceived barriers to a future occupation and academic achievement. Results indicated that females and males reported similar amounts of perceived barriers to a future occupation. Regression analysis indicated the relationship between perceived barriers and academic achievement varied across gender. For males, more perceived gender-barriers were associated with lower academic achievement, whereas, for females gender-barriers did not predict academic achievement. Although our hypothesis was not supported, the findings reveal an interesting phenomenon provoking the need for further study of gender, perceived barriers, and academic outcomes in delinquent populations

Systems for ultrasonic scanning, analysis and imagery

A variety of ultrasonic scanning and imagery techniques are used to investigate various aspects of materials and microstructures. Two ultrasonic scanning systems are in use by the Lewis Research Center's Structural Integrity Branch: an immersion scanner and a contact scanning system. The basic principles of scanning are reviewed, examples of images are presented, and structural features suggested by these images are discussed. Both of these systems are custom designed; their capabilities, advantages, and disadvantages are highlighted

Review and Statistical Analysis of the use of Ultrasonic Velocity for Estimating the Porosity Fraction in Polycrystalline Materials

The physical behavior of components manufactured from polycrystalline materials is in many cases directly dependent on the porosity fraction (volume fraction of pores). As examples concerning key properties of technologically-important materials, porosity fraction has been shown to affect (1) the strength, toughness and modulus of structural and refractory materials such as Steel [1], Tungsten [2], SiC [3], Si3N4 [3], and Al2O3 [3], (2) the strength of nuclear fuel materials such as UO2 [4–5]. (3) the thermal shock behavior and strength of porcelain-based ceramics [6–7], (4) the dielectric and elastic properties of piezoelectric materials such as PZT [8], and (5) the critical current density, diamagnetic response, and modulus of superconducting ceramics such as YBa2Cu3O7−x [9–11]. In such cases where physical properties are directly dependent on porosity fraction, the measurement of porosity fraction becomes important in the quality assurance process for the material

Promoting self-determination for transition-age youth: Views of high school general and special educators

This is the published version, also found here: http://cec.metapress.com/content/m5781621105k3332/?p=a26d6505487b4343b14b0042308735be&pi=2Recent developments in policy and practice have emphasized the importance of promoting self-determination and supporting access to the general curriculum for youth with disabilities. To understand how these trends align, we examined the efforts of 340 general and special educators to promote student self-determination in high school classrooms. Educators attached considerable importance to providing instruction in skills related to self-determination and reported addressing these skills with moderate to high frequency in their classrooms. Although opportunities for students with disabilities to learn skills that promote self-determination were reported to be available across the curriculum, there were some differences across teachers and curricular area. We discuss avenues for promoting student self-determination within the general curriculum, as well as offer recommendations for future research

Aluminium metallisation for interdigitated back contact silicon heterojunction solar cells

Back contact silicon heterojunction solar cells with an efficiency of 22 were manufactured, featuring a simple aluminium metallisation directly on the doped amorphous silicon films. Both the open circuit voltage and the fill factor heavily depend on the parameters of the annealing step after aluminium layer deposition. Using numerical device simulations and in accordance with the literature, we demonstrate that the changes in solar cell parameters with annealing can be explained by the formation of an aluminium silicide layer at temperatures as low as 150 C, improving the contact resistance and thus enhancing the fill factor. Further annealing at higher temperatures initialises the crystallisation of the amorphous silicon layers, yielding even lower contact resistances, but also introduces more defects, diminishing the open circuit voltag

Is It Always Unethical to Use a Placebo in a Clinical Trial?

Background to the debate: Placebos are used in trials to conceal whether a treatment is being given or not and hence to control for the psychosomatic effects of offering treatment. Placebo-controlled trials are controversial. Critics of such trials argue that if a proven effective therapy exists, a placebo should not be used. But proponents argue that placebo trials are still crucial to prove the efficacy and safety of many treatments