Phase-Coherent Dynamics of a Superconducting Flux Qubit with Capacitive-Bias Readout

We present a systematic study of the phase-coherent dynamics of a superconducting three-Josephson-junction flux qubit. The qubit state is detected with the integrated-pulse method, which is a variant of the pulsed switching DC SQUID method. In this scheme the DC SQUID bias current pulse is applied via a capacitor instead of a resistor, giving rise to a narrow band-pass instead of a pure low-pass filter configuration of the electromagnetic environment. Measuring one and the same qubit with both setups allows a direct comparison. With the capacitive method about four times faster switching pulses and an increased visibility are achieved. Furthermore, the deliberate engineering of the electromagnetic environment, which minimizes the noise due to the bias circuit, is facilitated. Right at the degeneracy point the qubit coherence is limited by energy relaxation. We find two main noise contributions. White noise is limiting the energy relaxation and contributing to the dephasing far from the degeneracy point. 1/f-noise is the dominant source of dephasing in the direct vicinity of the optimal point. The influence of 1/f-noise is also supported by non-random beatings in the Ramsey and spin echo decay traces. Numeric simulations of a coupled qubit-oscillator system indicate that these beatings are due to the resonant interaction of the qubit with at least one point-like fluctuator, coupled especially strongly to the qubit.Comment: Minor changes. 21 pages, 15 figure

Anti-Retroviral Treatment Outcomes among Older Adults in Zomba District, Malawi

BACKGROUND: There are approximately 3 million people aged 50 and older in sub-Saharan Africa who are HIV-positive. Despite this, little is known about the characteristics of older adults who are on treatment and their treatment outcomes. METHODS: A retrospective cohort analysis was performed using routinely collected data with Malawi Ministry of Health monitoring tools from facilities providing antiretroviral therapy services in Zomba district. Patients aged 25 years and older initiated on treatment from July 2005 to June 2010 were included. Differences in survival, by age group, were determined using Kaplan-Meier survival plots and Cox proportional hazards regression models. RESULTS: There were 10,888 patients aged 25 and older. Patients aged 50 and older (N = 1419) were more likely to be male (P<0.0001) and located in rural areas (P = 0.003) than those aged 25-49. Crude survival estimates among those aged 50-59 were not statistically different from those aged 25-49 (P = 0.925). However, survival among those aged 60 and older (N = 345) was worse (P = 0.019) than among those 25-59. In the proportional hazards model, after controlling for sex and stage at initiation, survival in those aged 50-59 did not differ significantly from those aged 25-49 (hazard ratio 1.00 (95% CI: 0.79 to 1.27; P = 0.998) but the hazard ratio was 1.46 (95% CI: 1.03 to 2.06; P = 0.032) for those aged 60 and older compared to those aged 25-49. CONCLUSIONS: Treatment outcomes of those aged 50-59 are similar to those aged 25-49. A better understanding of how older adults present for and respond to treatment is critical to improving HIV services

Fisheries Statistics for Lake Victoria, Tanzania

This research article published by Springer Nature Switzerland AG., 2017Time series fisheries statistics data mainly from Frame Surveys, Catch Assessment Surveys and Fisheries Annual Statistics Reports for Lake Victoria from 1967–2016 were collected from the Fisheries Development Division in Tanzania. These surveys and reports comprised relevant information and data on fish catches and fishing effort. The data were analysed and used to describe variations and trends in the number of fishers, number of fishing crafts, fish weight, catch per boat, total number of gillnets, beach seines, longline hooks, outboard and inboard engines. Frame Survey results showed an increasing trend in the number of fishers and fishing crafts, with the highest number of fishers and fishing crafts being 109,397 and 31,773, respectively in 2016. Longline hooks increased from 2,200,901 in 2000 to 8,163,119 hooks in 2016. In general, the catch per unit effort (CPUE) for all species was high at 39 mt/boat/year in 1967 and decreased to 8 mt/boat/year in 2014. However, CPUE for Lates niloticus has increased since the late 1980s, with the highest CPUE of 19.22 mt/boat/year being recorded in 1995, and from 2000 it decreased gradually to 7 mt/boat/year in 2014. As the fisheries statistics show an increase in fishing pressure over the years, it is evident that there is a sign of overfishing. For that matter, effective fisheries management is needed for the three riparian states to safeguard the sustainable use of fishery resources in the lake and to provide data that can be used in the evaluation of the fisheries objectives

A systematic study of the hybrid experiment at Mt.Chacaltaya

In the hybrid experiment on Mt.Chacaltaya, we can observe three different components of airshowers, that is, air-shower size, burst-density and high energy families (a bundle of high energy particles). Burst-density in each block of hadron calorimeters are newly recalculated in simulations in oder to compare directly to the experimental data. Energy deposits in the scintillators of the hadron calorimeters are calculated using GEANT4 for every particle, incident upon the hadron calorimeter, in the air-showers simulated using CORSIKA, and are converted into burst-density, taking into consideration the exact structure of experimental hadron calorimeter. We study correlations among three observable components in the air-showers. Correlations between air-shower size and burst-density and those between air-shower size and accompanied family energy can be explained by model calculations by adjusting primary particle composition, the former correlation is in favor of proton-primaries but the latter iron-primaries. No model can describe well observed correlations between burst-density and family energy. That is, the observed family energy accompanied by the air-showers with larger burst-density is systematically smaller than that expected in the simulated events. Effects of a fluctuation in the cross-section of hadronic interactions are studied to settle the disagreement between experimental data and simulations

Small Estuarine and Non-Estuarine Mangrove Ecosystems of Tanzania: Overlooked Coastal Habitats?

This research article published by Springer Nature Switzerland AG., 2016Small estuaries and non-estuarine habitats harboring mangroves are very important ecosystems which provide important ecosystem goods and services; such as provision of ecological niches for juvenile fishes and invertebrates, enhances fisheries, and in biodiversity conservation. Similar to large estuaries, they are highly perturbed which threatens their existence. This chapter uses beach seine, underwater visual census, and stable isotope data to discuss the importance of and threats to small estuaries and non-estuarine mangroves found in Dar es Salaam, Bagamoyo and Zanzibar, Tanzania. For example, mangroves of Kunduchi (Dar es Salaam) and Mbegani (Bagamoyo) which harbour predominantly higher densities of juveniles (≤10 cm) of two economically important species—Lutjanus fulviflamma and Lethrinus harak—than adjacent coral reefs. Evidence suggests further that the Kunduchi mangroves replenish fish populations on adjacent coral reefs; where over 90% and 29% of adult L. fulviflamma and L. harak individuals, respectively, have been identified to have lived in the mangroves as juveniles. In terms of habitat utilization by different size classes of fish, five of the 13 species (Lethrinus lentjan, L. variegatus, Pelates quadrilineatus, Siganus sutor and Sphyraena barracuda) found in Chwaka Bay (Zanzibar) were found as small-sized individuals in shallow and turbid mangrove areas with large juveniles and sub-adults in adjacent seagrass beds. The non-estuarine mangroves of Kunduchi and those of Mtoni estuary (Dar es Salaam) are subjected to pollution from urban activities. For example, stable isotope data of fishes indicate elevated levels of nitrogen in these mangroves with highest levels (δ15N = 15.2 ± 0.2) recorded in Mtoni estuary. In view of their importance and threats they face, these ecosystems require attention similar to large estuaries. If the current degradation rate of these ‘overlooked’ but equally important ecosystems continues, they may be declared ‘functionally disappeared’ in a few decades

Biological Functions of Mammalian Nit1, the Counterpart of the Invertebrate NitFhit Rosetta Stone Protein, a Possible Tumor Suppressor

The "Rosetta Stone" hypothesis proposes that the existence of a fusion protein in some organisms predicts that the separate polypeptides function in the same biochemical pathway in other organisms and may physically interact. In Drosophila melanogaster and Caenorhabditis elegans, NitFhit protein is composed of two domains, a fragile histidine triad homolog and a bacterial and plant nitrilase homolog. We assessed the biological effects of mammalian Nit1 expression in comparison with Fhit and observed that: 1) Nit1 expression was observed in most normal tissues and overlapped partially with Fhit expression; 2) Nit1-deficient mouse kidney cells exhibited accelerated proliferation, resistance to DNA damage stress, and increased cyclin D1 expression; 3) cyclin D1 was up-regulated in Nit1 null mammary gland and skin; 4) Nit1 overexpression induced caspase-dependent apoptosis in vitro; and 5) Nit1 allele deficiency led to increased incidence of N-nitrosomethylbenzylamine-induced murine forestomach tumors. Thus, the biological effects of Nit1 expression are similar to Fhit effects. Adenoviruses carrying recombinant NIT1 and FHIT induced apoptosis in Fhit- and Nit1-deficient cells, respectively, suggesting that Nit1-Fhit interaction is not essential for function of either protein. The results suggest that Nit1 and Fhit share tumor suppressor signaling pathways, while localization of the NIT1 gene at a stable, rather than fragile, chromosome site explains the paucity of gene alterations and in frequent loss of expression of the NIT1 gene in human malignancies

Linking Genotype and Phenotype of Saccharomyces cerevisiae Strains Reveals Metabolic Engineering Targets and Leads to Triterpene Hyper-Producers

Background: Metabolic engineering is an attractive approach in order to improve the microbial production of drugs. Triterpenes is a chemically diverse class of compounds and many among them are of interest from a human health perspective. A systematic experimental or computational survey of all feasible gene modifications to determine the genotype yielding the optimal triterpene production phenotype is a laborious and time-consuming process. Methodology/Principal Findings: Based on the recent genome-wide sequencing of Saccharomyces cerevisiae CEN.PK 113-7D and its phenotypic differences with the S288C strain, we implemented a strategy for the construction of a beta-amyrin production platform. The genes Erg8, Erg9 and HFA1 contained non-silent SNPs that were computationally analyzed to evaluate the changes that cause in the respective protein structures. Subsequently, Erg8, Erg9 and HFA1 were correlated with the increased levels of ergosterol and fatty acids in CEN.PK 113-7D and single, double, and triple gene over-expression strains were constructed. Conclusions: The six out of seven gene over-expression constructs had a considerable impact on both ergosterol and beta-amyrin production. In the case of beta-amyrin formation the triple over-expression construct exhibited a nearly 500% increase over the control strain making our metabolic engineering strategy the most successful design of triterpene microbial producers

Fluxoid dynamics in superconducting thin film rings

We have measured the dynamics of individual magnetic fluxoids entering and leaving photolithographically patterned thin film rings of the underdoped high-temperature superconductor Bi$_2$Sr$_2$CaCu$_2$O$_{8+\delta}$, using a variable sample temperature scanning SQUID microscope. These results can be qualitatively described using a model in which the fluxoid number changes by thermally activated nucleation of a Pearl vortex in, and transport of the Pearl vortex across, the ring wall.Comment: 9 pages, 10 figures, fixed typo