Age at work:Explaining variation in frames of older employees in corporate and news media

Despite the fact that workforce aging is recognized as a key social and economic concern of developed countries, previous research has largely neglected the role of corporate and news media in the debate about this topic. Relying on a content analysis of five Dutch newspapers and the corporate media of 50 Dutch organizations (N = 1328), this study traces variation in frames of older workers’ employability. Results reveal that organizations in their corporate media attempt to avoid associations with problems related to older employees and highlight the solutions they offer, while news media are more inclined to problematize the issue and victimize older employees. This study elucidates our understanding of how corporate and news media communicatively deal with older workers’ employability, and how key actors drive frame-formation processes in both domains

Intranasal Vaccination With Lipoproteins Confers Protection Against Pneumococcal Colonisation

Streptococcus pneumoniae is endowed with a variety of surface-exposed proteins representing putative vaccine candidates. Lipoproteins are covalently anchored to the cell membrane and highly conserved among pneumococcal serotypes. Here, we evaluated these lipoproteins for their immunogenicity and protective potential against pneumococcal colonisation. A multiplex-based immunoproteomics approach revealed the immunogenicity of selected lipoproteins. High antibody titres were measured in sera from mice immunised with the lipoproteins MetQ, PnrA, PsaA, and DacB. An analysis of convalescent patient sera confirmed the immunogenicity of these lipoproteins. Examining the surface localisation and accessibility of the lipoproteins using flow cytometry indicated that PnrA and DacB were highly abundant on the surface of the bacteria. Mice were immunised intranasally with PnrA, DacB, and MetQ using cholera toxin subunit B (CTB) as an adjuvant, followed by an intranasal challenge with S. pneumoniae D39. PnrA protected the mice from pneumococcal colonisation. For the immunisation with DacB and MetQ, a trend in reducing the bacterial load could be observed, although this effect was not statistically significant. The reduction in bacterial colonisation was correlated with the increased production of antigen-specific IL-17A in the nasal cavity. Immunisation induced high systemic IgG levels with a predominance for the IgG1 isotype, except for DacB, where IgG levels were substantially lower compared to MetQ and PnrA. Our results indicate that lipoproteins are interesting targets for future vaccine strategies as they are highly conserved, abundant, and immunogenic

Complement factor H serum levels determine resistance to pneumococcal invasive disease

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