A New Anomaly-Free Gauged Supergravity in Six Dimensions

We present a new anomaly-free gauged N=1 supergravity model in six dimensions. The gauge group is E_7xG_2xU(1)_R, with all hyperinos transforming in the product representation {56,14). The theory admits monopole compactifications to R^4xS^2, leading to D=4 effective theories with broken supersymmetry and massless fermions.Comment: 9 pages, RevTeX

Mutations of the ret protooncogene in German multiple endocrine neoplasia families: Relation between genotype and phenotype.

It has been suggested that not only the position but also the nature of the mutations of the ret protooncogene strongly correlate with the clinical manifestation of the multiple endocrine neoplasm type 2 (MEN 2) syndrome. In particular, individuals with a Cys634-Arg substitution should have a greater risk of developing parathyroid disease. We, therefore, analyzed 94 unrelated families from Germany with inherited medullary thyroid carcinoma (MTC) for mutation of the ret protooncogene. In all but 1 of 59 families with MEN 2A, germline mutations in the extracellular domain of the ret protein were found. Some 81% of the MEN 2A mutations affected codon 634. Phenotype-genotype correlations suggested that the prevalence of pheochromocytoma and hyperparathyroidism is significantly higher in families with codon 634 mutations, but there was no correlation with the nature of the mutation. In all but 1 of 27 familial MTC (FMTC) families, mutations were detected in 1 of 4 cysteines in the extracellular domain of the ret protooncogene. Half of the FMTC mutations affected codon 634. Mutations outside of codon 634 occurred more often in FMTC families than in MEN 2A families. In all but 1 of 8 MEN 2B patients, de novo mutations in codon 918 were found. These data confirm the preferential localization of MEN 2-associated mutations and the correlation between disease phenotype and the position of the ret mutation, but there was no correlation between the occurrence of hyperparathyroidism or pheochromocytoma and the nature of the mutation

QED from six-dimensional vortex and gauge anomalies

Starting from an anomaly-free Abelian Higgs model coupled to gravity in a 6-dimensional space-time we construct an effective four-dimensional theory of charged fermions interacting with U(1) Abelian gauge field and gravity, both localised near the core of a Nielsen-Olesen vortex configuration. We show that an anomaly free theory in 6-dimensions can give rise to an anomalous theory in D=4, which suggests a possibility of consistent regularisation of abelian anomalous chiral gauge theories in four dimensions. We also show that the spectrum of charged bulk fermions has a mass gap.Comment: Latex, 19 page

Universal spectral statistics of Andreev billiards: semiclassical approach

The classification of universality classes of random-matrix theory has recently been extended beyond the Wigner-Dyson ensembles. Several of the novel ensembles can be discussed naturally in the context of superconducting-normal hybrid systems. In this paper, we give a semiclassical interpretation of their spectral form factors for both quantum graphs and Andreev billiards.Comment: final improved version (to be published in Physical Review E), 6 pages, revtex

Compression of Antiproton Clouds for Antihydrogen Trapping

Control of the radial profile of trapped antiproton clouds is critical to trapping antihydrogen. We report the first detailed measurements of the radial manipulation of antiproton clouds, including areal density compressions by factors as large as ten, by manipulating spatially overlapped electron plasmas. We show detailed measurements of the near-axis antiproton radial profile and its relation to that of the electron plasma

Hookworm Infection and Environmental Factors in Mbeya Region, Tanzania: A Cross-sectional, Population-based study.

Hookworm disease is one of the most common infections and cause of a high disease burden in the tropics and subtropics. Remotely sensed ecological data and model-based geostatistics have been used recently to identify areas in need for hookworm control. Cross-sectional interview data and stool samples from 6,375 participants from nine different sites in Mbeya region, south-western Tanzania, were collected as part of a cohort study. Hookworm infection was assessed by microscopy of duplicate Kato-Katz thick smears from one stool sample from each participant. A geographic information system was used to obtain remotely sensed environmental data such as land surface temperature (LST), vegetation cover, rainfall, and elevation, and combine them with hookworm infection data and with socio-demographic and behavioral data. Uni- and multivariable logistic regression was performed on sites separately and on the pooled dataset. Univariable analyses yielded significant associations for all ecological variables. Five ecological variables stayed significant in the final multivariable model: population density (odds ratio (OR) = 0.68; 95% confidence interval (CI) = 0.63-0.73), mean annual vegetation density (OR = 0.11; 95% CI = 0.06-0.18), mean annual LST during the day (OR = 0.81; 95% CI = 0.75-0.88), mean annual LST during the night (OR = 1.54; 95% CI = 1.44-1.64), and latrine coverage in household surroundings (OR = 1.02; 95% CI = 1.01-1.04). Interaction terms revealed substantial differences in associations of hookworm infection with population density, mean annual enhanced vegetation index, and latrine coverage between the two sites with the highest prevalence of infection. This study supports previous findings that remotely sensed data such as vegetation indices, LST, and elevation are strongly associated with hookworm prevalence. However, the results indicate that the influence of environmental conditions can differ substantially within a relatively small geographic area. The use of large-scale associations as a predictive tool on smaller scales is therefore problematic and should be handled with care

Prenatal Vitamin D Supplementation and Child Respiratory Health: A Randomised Controlled Trial

PMCID: PMC3691177This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

A novel antiproton radial diagnostic based on octupole induced ballistic loss

We report results from a novel diagnostic that probes the outer radial profile of trapped antiproton clouds. The diagnostic allows us to determine the profile by monitoring the time-history of antiproton losses that occur as an octupole field in the antiproton confinement region is increased. We show several examples of how this diagnostic helps us to understand the radial dynamics of antiprotons in normal and nested Penning-Malmberg traps. Better understanding of these dynamics may aid current attempts to trap antihydrogen atoms

The Mechanisms of Codon Reassignments in Mitochondrial Genetic Codes

Many cases of non-standard genetic codes are known in mitochondrial genomes. We carry out analysis of phylogeny and codon usage of organisms for which the complete mitochondrial genome is available, and we determine the most likely mechanism for codon reassignment in each case. Reassignment events can be classified according to the gain-loss framework. The gain represents the appearance of a new tRNA for the reassigned codon or the change of an existing tRNA such that it gains the ability to pair with the codon. The loss represents the deletion of a tRNA or the change in a tRNA so that it no longer translates the codon. One possible mechanism is Codon Disappearance, where the codon disappears from the genome prior to the gain and loss events. In the alternative mechanisms the codon does not disappear. In the Unassigned Codon mechanism, the loss occurs first, whereas in the Ambiguous Intermediate mechanism, the gain occurs first. Codon usage analysis gives clear evidence of cases where the codon disappeared at the point of the reassignment and also cases where it did not disappear. Codon disappearance is the probable explanation for stop to sense reassignments and a small number of reassignments of sense codons. However, the majority of sense to sense reassignments cannot be explained by codon disappearance. In the latter cases, by analysis of the presence or absence of tRNAs in the genome and of the changes in tRNA sequences, it is sometimes possible to distinguish between the Unassigned Codon and Ambiguous Intermediate mechanisms. We emphasize that not all reassignments follow the same scenario and that it is necessary to consider the details of each case carefully.Comment: 53 pages (45 pages, including 4 figures + 8 pages of supplementary information). To appear in J.Mol.Evo

Stock markets, financial development and economic growth in sub-Saharan Africa

In general, this study examines the Stock Market, Financial Development and Economic Growth in selected sub-Sahara African countries. Empirically, Chapter Two of the study used Generalised Method of Moment (GMM) dynamic instrumental variable approach to investigate financial development and economic growth nexus in the East African countries. Also, the study applied both Fixed Effect Estimation (FEM) techniques and Panel vector autoregressive (PVAR) to analyse the causal effects of equity market development on economic growth in eleven sub-Sahara African countries, in Chapter Three of this study. On the other hand, Chapter Four of this study measures the conditional variance (volatility) of the stock returns of Tanzanian stock market (Dar-es-Salaam Stock Exchange). For modelling stock market return volatility, we use both standard and asymmetric GARCH models to capture the volatility clustering and asymmetric features in the financial data of the companies selected.To attain the objectives of all three empirical chapters highlighted above, this study had to consider various important and necessary tests; such as tests for unit root, to check if the expected variables were stationary, and tests for cointegration to check whether there was a long-run equilibrium relationship between variables under study in Chapter Two and Chapter Three. However, in Chapter Four (modelling volatility) we tested for an additional ARCH effects apart from stationarity (unit root) tests we have had. Specifically, this study found that there is causal relationship between financial development (when presented by indicator domestic credit to private sector) and economic growth in the East African countries (EAC). Also, we found that the domestic credit to private sector as an indicator for financial development has a role to play in economic growth of EAC.Moreover, we find that there is unidirectional Granger causality, which flows from equity market development (using indicator market capitalization rate-MCR) to economic growth of the panel of 11 sub-Sahara African countries. We also declare that stock market development via MCR play a positive role in SSA economic growth. In addition, the study reveals that there is existence of leverage effects in Tanzanian stock market, therefore, the bad news (negative shocks) reflect an increase in the conditional variance (volatility) of DSE stock returns for the next period than the good news. However, we find that the volatility clustering exists in Tanzanian stock market returns