A PVC Detection Program

journal articleBiomedical Informatic

Effects of Hyperbolic Rotation in Minkowski Space on the Modeling of Plasma Accelerators in a Lorentz Boosted Frame

Laser driven plasma accelerators promise much shorter particle accelerators but their development requires detailed simulations that challenge or exceed current capabilities. We report the first direct simulations of stages up to 1 TeV from simulations using a Lorentz boosted calculation frame resulting in a million times speedup, thanks to a frame boost as high as gamma=1300. Effects of the hyperbolic rotation in Minkowski space resulting from the frame boost on the laser propagation in the plasma is shown to be key in the mitigation of a numerical instability that was limiting previous attempts

Quasi-monoenergetic femtosecond photon sources from Thomson Scattering using laser plasma accelerators and plasma channels

Narrow bandwidth, high energy photon sources can be generated by Thomson scattering of laser light from energetic electrons, and detailed control of the interaction is needed to produce high quality sources. We present analytic calculations of the energy-angular spectra and photon yield that parametrize the influences of the electron and laser beam parameters to allow source design. These calculations, combined with numerical simulations, are applied to evaluate sources using conventional scattering in vacuum and methods for improving the source via laser waveguides or plasma channels. We show that the photon flux can be greatly increased by using a plasma channel to guide the laser during the interaction. Conversely, we show that to produce a given number of photons, the required laser energy can be reduced by an order of magnitude through the use of a plasma channel. In addition, we show that a plasma can be used as a compact beam dump, in which the electron beam is decelerated in a short distance, thereby greatly reducing radiation shielding. Realistic experimental errors such as transverse jitter are quantitatively shown to be tolerable. Examples of designs for sources capable of performing nuclear resonance fluorescence and photofission are provided

Laser-heater assisted plasma channel formation in capillary discharge waveguides

A method of creating plasma channels with controllable depth and transverse profile for the guiding of short, high power laser pulses for efficient electron acceleration is proposed. The plasma channel produced by the hydrogen-filled capillary discharge waveguide is modified by a ns-scale laser pulse, which heats the electrons near the capillary axis. This interaction creates a deeper plasma channel within the capillary discharge that evolves on a ns-time scale, allowing laser beams with smaller spot sizes than would otherwise be possible in the unmodified capillary discharge.Comment: 5 pages, 3 figure

Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis

Objective To assess whether lithium has a specific preventive effect for suicide and self harm in people with unipolar and bipolar mood disorders. Design Systematic review and meta-analysis. Data sources Medline, Embase, CINAHL, PsycINFO, CENTRAL, web based clinical trial registries, major textbooks, authors of important papers and other experts in the discipline, and websites of pharmaceutical companies that manufacture lithium or the comparator drugs (up to January 2013). Inclusion criteria Randomised controlled trials comparing lithium with placebo or active drugs in long term treatment for mood disorders. Review methods Two reviewers assessed studies for inclusion and risk of bias and extracted data. The main outcomes were the number of people who completed suicide, engaged in deliberate self harm, and died from any cause. Results 48 randomised controlled trials (6674 participants, 15 comparisons) were included. Lithium was more effective than placebo in reducing the number of suicides (odds ratio 0.13, 95% confidence interval 0.03 to 0.66) and deaths from any cause (0.38, 0.15 to 0.95). No clear benefits were observed for lithium compared with placebo in preventing deliberate self harm (0.60, 0.27 to 1.32). In unipolar depression, lithium was associated with a reduced risk of suicide (0.36, 0.13 to 0.98) and also the number of total deaths (0.13, 0.02 to 0.76) compared with placebo. When lithium was compared with each active individual treatment a statistically significant difference was found only with carbamazepine for deliberate self harm. Lithium tended to be generally better than the other active comparators, with small statistical variation between the results. Conclusions Lithium is an effective treatment for reducing the risk of suicide in people with mood disorders. Lithium may exert its antisuicidal effects by reducing relapse of mood disorder, but additional mechanisms should also be considered because there is some evidence that lithium decreases aggression and possibly impulsivity, which might be another mechanism mediating the antisuicidal effect

Laminar flow of two miscible fluids in a simple network

When a fluid comprised of multiple phases or constituents flows through a network, non-linear phenomena such as multiple stable equilibrium states and spontaneous oscillations can occur. Such behavior has been observed or predicted in a number of networks including the flow of blood through the microcirculation, the flow of picoliter droplets through microfluidic devices, the flow of magma through lava tubes, and two-phase flow in refrigeration systems. While the existence of non-linear phenomena in a network with many inter-connections containing fluids with complex rheology may seem unsurprising, this paper demonstrates that even simple networks containing Newtonian fluids in laminar flow can demonstrate multiple equilibria. The paper describes a theoretical and experimental investigation of the laminar flow of two miscible Newtonian fluids of different density and viscosity through a simple network. The fluids stratify due to gravity and remain as nearly distinct phases with some mixing occurring only by diffusion. This fluid system has the advantage that it is easily controlled and modeled, yet contains the key ingredients for network non-linearities. Experiments and 3D simulations are first used to explore how phases distribute at a single T-junction. Once the phase separation at a single junction is known, a network model is developed which predicts multiple equilibria in the simplest of networks. The existence of multiple stable equilibria is confirmed experimentally and a criteria for their existence is developed. The network results are generic and could be applied to or found in different physical systems

Low transverse emittance electron bunches from two-color laser-ionization injection

A method is proposed to generate low emittance electron bunches from two color laser pulses in a laser-plasma accelerator. A two-region gas structure is used, containing a short region of a high-Z gas (e.g., krypton) for ionization injection, followed by a longer region of a low-Z gas for post-acceleration. A long-laser-wavelength (e.g., 5 micron) pump pulse excites plasma wake without triggering the inner-shell electron ionization of the high-Z gas due to low electric fields. A short-laser-wavelength (e.g., 0.4 micron) injection pulse, located at a trapping phase of the wake, ionizes the inner-shell electrons of the high-Z gas, resulting in ionization-induced trapping. Compared with a single-pulse ionization injection, this scheme offers an order of magnitude smaller residual transverse momentum of the electron bunch, which is a result of the smaller vector potential amplitude of the injection pulse