Analysis of radar images of the active volcanic zone at Krafla, Iceland: The effects of look azimuth biasing

The geomorphic expression of Mid-Ocean-Ridge (MOR) volcanism in a subaerial setting occurs uniquely on Earth in Iceland, and the most recent MOR eruptive activity has been concentrated in the Northeastern Volcanic Zone in an area known as Krafla. Within the Krafla region are many of the key morphologic elements of MOR-related basaltic volcanism, as well as volcanic explosion craters, subglacial lava shields, tectonic fissure swarms known as gjar, and basaltic-andesite flows with well developed ogives (pressure-ridges). The objective was to quantify the degree to which the basic volcanic and structural features can be mapped from directional SAR imagery as a function of the look azimuth. To accomplish this, the current expression of volcanic and tectonic constructs was independently mapped within the Krafla region on the E, W, and N-looking SAR images, as well as from SPOT Panchromatic imagery acquired in 1987. The initial observations of the E, W, and N images indicates that fresh a'a lava surfaces are extremely radar bright (rough at 3 cm to meter scales) independent of look direction; this suggests that these flows do not have strong flow direction related structures at meter and cm scales, which is consistent with typical Icelandic a'a lava surfaces in general. The basic impression from a preliminary analysis of the effects of look azimuth biasing on interpretation of the geology of an active MOR volcanic zone is that up to 30 percent of the diagnostic features can be missed at any given look direction, but that having two orthogonal look direction images is probably sufficient to prevent gross misinterpretation

Performance of a Y-Ba-Cu-O superconducting filter/GaAs low noise amplifier hybrid circuit

A superconducting 7.3 GHz two-pole microstrip bandpass filter and a GaAs low noise amplifier (LNA) were combined into an active circuit and characterized at liquid nitrogen temperatures. This superconducting/semiconducting circuit's performance was compared to a gold filter/GaAs LNA hybrid circuit. The superconducting filter/GaAs LNA hybrid circuit showed higher gain and lower noise figure than its gold counterpart

From Scepticism to Liberalism? Bernard Williams, the Foundations of Liberalism and Political Realism.

Bernard Williams was an ethical sceptic, but he was also a proponent of liberalism. To what extent can one finally be both? This article explores this question through a particular emphasis on Williams, but seeks to draw wider lessons regarding what ethical scepticism should and should not amount to. It shows how ethical scepticism can be reconciled with a commitment to what Williams, following Judith Shklar, called ‘the liberalism of fear’, which is revealed as an ecumenical outlook for different stripes of ethical sceptic. The article concludes by drawing some lessons for the recent ‘realist’ turn in political theory.Research for this article was undertaken while I was the recipient of an Arts and Humanities Research Council PhD studentship at the University of Cambridge, and was later supported by the Cambridge Faculty of History’s Prince Consort and Thirlwall fund

Asymptotics of the Heat Kernel on Rank 1 Locally Symmetric Spaces

We consider the heat kernel (and the zeta function) associated with Laplace type operators acting on a general irreducible rank 1 locally symmetric space X. The set of Minakshisundaram- Pleijel coefficients {A_k(X)}_{k=0}^{\infty} in the short-time asymptotic expansion of the heat kernel is calculated explicitly.Comment: 11 pages, LaTeX fil

Fast Witness Extraction Using a Decision Oracle

The gist of many (NP-)hard combinatorial problems is to decide whether a universe of $n$ elements contains a witness consisting of $k$ elements that match some prescribed pattern. For some of these problems there are known advanced algebra-based FPT algorithms which solve the decision problem but do not return the witness. We investigate techniques for turning such a YES/NO-decision oracle into an algorithm for extracting a single witness, with an objective to obtain practical scalability for large values of $n$. By relying on techniques from combinatorial group testing, we demonstrate that a witness may be extracted with $O(k\log n)$ queries to either a deterministic or a randomized set inclusion oracle with one-sided probability of error. Furthermore, we demonstrate through implementation and experiments that the algebra-based FPT algorithms are practical, in particular in the setting of the $k$-path problem. Also discussed are engineering issues such as optimizing finite field arithmetic.Comment: Journal version, 16 pages. Extended abstract presented at ESA'1

Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-ß oligomers released from 7PA2 cells

The amyloid hypothesis of Alzheimer's disease suggests that synaptic degeneration and pathology is caused by the accumulation of amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP). Subsequently, soluble Aβ oligomers cause the loss of synaptic proteins from neurons, a histopathological feature of Alzheimer's disease that correlates with the degree of dementia. In this study, the production of toxic forms of Aβ was examined in vitro using 7PA2 cells stably transfected with human APP. We show that conditioned media from 7PA2 cells containing Aβ oligomers caused synapse degeneration as measured by the loss of synaptic proteins, including synaptophysin and cysteine-string protein, from cultured neurons. Critically, conditioned media from 7PA2 cells treated with valproic acid (2-propylpentanoic acid (VPA)) or propylisopropylacetic acid (PIA) did not cause synapse damage. Treatment with VPA or PIA did not significantly affect total Aβ42 concentrations; rather these drugs selectively reduced the concentrations of Aβ42 oligomers in conditioned media. In contrast, treatment significantly increased the concentrations of Aβ42 monomers in conditioned media. VPA or PIA treatment reduced the concentrations of APP within lipid rafts, membrane compartments associated with Aβ production. These effects of VPA and PIA were reversed by the addition of platelet-activating factor, a bioactive phospholipid produced following activation of phospholipase A2, an enzyme sensitive to VPA and PIA. Collectively these data suggest that VPA and PIA reduce Aβ oligomers through inhibition of phospholipase A2 and suggest a novel therapeutic approach to Alzheimer's treatment

Harvardiana : March Song

https://digitalcommons.library.umaine.edu/mmb-vp/4967/thumbnail.jp