Pilot describing function measurements in a multiloop task

Pilot describing function measurements in multiloop control system tracking tas

Principles for the design of advanced flight director systems based on the theory of manual control displays

Design and development of flight director systems based on theory of manual control display

Small perturbation dynamics of the neuromuscular system in tracking tasks

Small perturbation dynamics of neuromuscular system in tracking task

Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones

Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for,10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e. g. catheters, prothesis and implanted heart valve etc.) facilitated by several extracellular adhesive factors including fimbrial pili. Several clusters containing fimbrial genes have been previously identified on the P. aeruginosa chromosome and named cup [1]. The assembly of the CupB pili is thought to be coordinated by two chaperones, CupB2 and CupB4. However, due to the lack of structural and biochemical data, their chaperone activities remain speculative. In this study, we report the 2.5 A crystal structure of P. aeruginosa CupB2. Based on the structure, we further tested the binding specificity of CupB2 and CupB4 towards CupB1 (the presumed major pilus subunit) and CupB6 (the putative adhesin) using limited trypsin digestion and strep-tactin pull-down assay. The structural and biochemical data suggest that CupB2 and CupB4 might play different, but not redundant, roles in CupB secretion. CupB2 is likely to be the chaperone of CupB1, and CupB4 could be the chaperone of CupB4:CupB5:CupB6, in which the interaction of CupB4 and CupB6 might be mediated via CupB5

Shildrick’s monster: exploring a new approach to difference/disability through collective biography

Working with memories generated in a collective biography workshop on difference/disability and drawing in particular on Shildrick’s (2002) analysis of monstrosity, this paper analyses the ambivalent processes through which difference is othered and abjected. It argues that through the process of abjection we disown for ourselves whatever qualities are being categorised as monstrous, with negative effects not just on the other, but also on the self. We look at the ambivalence of ‘reclaiming the monster’. The paper opens up an alternative of expanding the possibilities of being by focusing not on difference as categorical otherness, but rather difference as movement, as differenciation, or becoming