Comparison of aerodynamic noise from three nose-cylinder combinations

Results of experiments with three different cylinder and blunted nose combinations are discussed. Combinations include smooth cylinder with single 15 deg cone, smooth cylinder with double cone of 25 and 10 deg, and longitudinally corrugated cylinder with similar double cone

Gust penetration loads and elastic vehicle response for Saturn 5 launch vehicles

Analysis of gust penetration loads and associated elastic vehicle response of Saturn 5 launch vehicles AS-505 through AS-508 penetrating sinusoidal gust

The unconstrained evolution of fast and efficient antibiotic-resistant bacterial genomes

PublishedThis is the author accepted manuscript. The final version is available from Nature Publishing Group via the DOI in this record.-The rrn knockout strains derived from E. coli MG1655 were gifted by T. Bollenbach, strain AG100 was provided by S. Levy and Candida strains were a gift from S. Bates, who are sincerely thanked for their help

Internet Predictions

More than a dozen leading experts give their opinions on where the Internet is headed and where it will be in the next decade in terms of technology, policy, and applications. They cover topics ranging from the Internet of Things to climate change to the digital storage of the future. A summary of the articles is available in the Web extras section

The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.

In patients with infection and sepsis serum levels of Pancreatic Stone protein/regenerating protein I (PSP) are highly elevated. The origin of PSP during these conditions is presumably the pancreas, however, an intestinal origin cannot be excluded. Similarly, pancreatitis-associated protein (PAP) was identified in the pancreas. These proteins were also localized in intestinal organs. Here we aim to elucidate the bio-distribution of PSP and PAP in animal models of sepsis and in healthy humans. PSP and PAP responded to remote lesions in rats although the pancreatic response was much more pronounced than the intestinal. Tissue distribution of PSP demonstrated a 100-fold higher content in the pancreas compared to any other organ while PAP was most abundant in the small intestine. Both proteins responded to CLP or sham operation in the pancreas. PSP also increased in the intestine during CLP. The distribution of PSP and PAP in human tissue mirrored the distribution in the murine models. Distribution of PSP and PAP was visualized by immunohistochemistry. Rats and mice underwent midline laparotomies followed by mobilization of tissue and incision of the pancreatic duct or duodenum. Standard cecum-ligation-puncture (CLP) procedures or sham laparotomies were performed. Human tissue extracts were analyzed for PSP and PAP. The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas

Partly burnt runaway stellar remnants from peculiar thermonuclear supernovae

We report the discovery of three stars that, along with the prototype LP40-365, form a distinct class of chemically peculiar runaway stars that are the survivors of thermonuclear explosions. Spectroscopy of the four confirmed LP 40-365 stars finds ONe-dominated atmospheres enriched with remarkably similar amounts of nuclear ashes of partial O- and Si-burning. Kinematic evidence is consistent with ejection from a binary supernova progenitor; at least two stars have rest-frame velocities indicating they are unbound to the Galaxy. With masses and radii ranging between 0.20-0.28 Msun and 0.16-0.60 Rsun, respectively, we speculate these inflated white dwarfs are the partly burnt remnants of either peculiar Type Iax or electron-capture supernovae. Adopting supernova rates from the literature, we estimate that ~20 LP40-365 stars brighter than 19 mag should be detectable within 2 kpc from the Sun at the end of the Gaia mission. We suggest that as they cool, these stars will evolve in their spectroscopic appearance, and eventually become peculiar O-rich white dwarfs. Finally, we stress that the discovery of new LP40-365 stars will be useful to further constrain their evolution, supplying key boundary conditions to the modelling of explosion mechanisms, supernova rates, and nucleosynthetic yields of peculiar thermonuclear explosions.Comment: 22 pages, 14 figures, 6 tables. Accepted for publication on MNRA

Volunteering in the care of people with severe mental illness: a systematic review

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited