8,133 research outputs found
Meeting report : Neuropathology and Neuropharmacology of Monoaminergic systems
The third EU COST Action CM1103 “Structure-based drug design for diagnosis and treatment of neurological diseases: dissecting and modulating complex function in the monoaminergic systems of the brain” Annual Conference entitled “Neuropathology and Neuropharmacology of Monoaminergic Systems” was hosted by the University of Bordeaux, France on 8-10 October 2014. The conference, organized by Prof. De Deurwaerdère, was supported by COST (European Cooperation in Science and Technology) and LABEX (LABEX Brain, University of Bordeaux). The program took the form of a three-day meeting, comprising a series of French and international invited talks and breakout sessions designed to identify key gaps in current knowledge and potential future research questions. The aims of this Conference were two-fold: 1. To identify the current state-of-the-art in the understanding of the pathological mechanisms that contribute to different neuropsychiatric disorders, and to what extent, monoamines a multi-target drugs and/or other interventions might prevent these changes. 2. To identify specific areas of research where information is sparse but which are likely to yield data that will impact on future strategies to treat neurodegenerative disorders.peer-reviewe
Analysing randomised controlled trials with missing data : Choice of approach affects conclusions
Copyright © 2012 Elsevier Inc. All rights reserved. PMID: 22265924 [PubMed - indexed for MEDLINE]Peer reviewedPostprin
Using the literature to quantify the learning curve: a case study
Objective: To assess whether a literature review of a technology can allow a learning curve to be quantified. Methods: The literature for fibreoptic intubation was searched for studies reporting information relevant to the learning curve. The Cochrane Librar y, Medline, Embase and Science Citation index were searched. Studies that reported a procedure time were included. Data were abstracted on the three features of learning: initial level, rate of learning and asymptote level. Random effect meta-analysis was performed. Results: Only 21 studies gave explicit information concerning the previous experience of the operator(s). There were 32 different definitions of procedure time. From 4 studies of fibreoptic nasotracheal intubation, the mean starting level and time for the 10th procedure (95% confidence interval) was estimated to be 133s (113, 153) and 71s (62, 79) respectively. Conclusions: The review approach allowed learning to be quantified for our example technology. Poor and insufficient reporting constrained formal statistical estimation. Standardised reporting of non-drug techniques with adequate learning curve details is needed to inform trial design and costeffectiveness analysis
Infrared Line Emission from Planetary Nebulae. I - General Theory
General theory of infrared line emission from planetary nebul
Reporting and dealing with missing quality of life data in RCTs : has the picture changed in the last decade?
Peer reviewedPublisher PD
X-ray spectroscopy and photometry of the long-period polar AI Tri with XMM-Newton
Context. The energy balance of cataclysmic variables with strong magnetic
fields is a central subject in understanding accretion processes on magnetic
white dwarfs. With XMM-Newton, we perform a spectroscopic and photometric study
of soft X-ray selected polars during their high states of accretion. Aims. On
the basis of X-ray and optical observations of the magnetic cataclysmic
variable AI Tri, we derive the properties of the spectral components, their
flux contributions, and the physical structure of the accretion region in soft
polars. Methods. We use multi-temperature approaches in our xspec modeling of
the spectra to describe the physical conditions and the structures of the
post-shock accretion flow and the accretion spot on the white-dwarf surface. In
addition, we investigate the accretion geometry of the system by a timing
analysis of the photometric data. Results. Flaring soft X-ray emission from the
heated surface of the white dwarf dominates the X-ray flux during roughly 70%
of the binary cycle. This component deviates from a single black body and can
be described by a superimposition of mildly absorbed black bodies with a
Gaussian temperature distribution. In addition, weaker hard X-ray emission is
visible nearly all the time. The spectrum from the cooling post-shock accretion
flow is most closely fitted by a combination of thermal plasma mekal models
with temperature profiles adapted from prior stationary two-fluid hydrodynamic
calculations. The soft X-ray light curves show a dip during the bright phase,
which can be interpreted as self-absorption in the accretion stream.
Phase-resolved spectral modeling supports the picture of one-pole accretion and
self-eclipse. One of the optical light curves corresponds to an irregular mode
of accretion. During a short XMM-Newton observation at the same epoch, the
X-ray emission of the system is clearly dominated by the soft component.Comment: A&A, in press; 11 pages, 9 figures, 3 table
The use of segmented regression in analysing interrupted time series studies : an example in pre-hospital ambulance care
Peer reviewedPublisher PD
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