1,656 research outputs found
On Rigidity of 3d Asymptotic Symmetry Algebras
We study rigidity and stability of infinite dimensional algebras which are
not subject to the Hochschild-Serre factorization theorem. In particular, we
consider algebras appearing as asymptotic symmetries of three dimensional
spacetimes, the BMS3, u(1) Kac-Moody and Virasoro algebras. We construct and
classify the family of algebras which appear as deformations of BMS3, u(1)
Kac-Moody and their central extensions by direct computations and also by
cohomological analysis. The Virasoro algebra appears as a specific member in
this family of rigid algebras; for this case stabilization procedure is inverse
of the In\"on\"u-Wigner contraction relating Virasoro to BMS3 algebra. We
comment on the physical meaning of deformation and stabilization of these
algebras and relevance of the family of rigid algebras we obtainComment: 50 pages, one figure and two tables; v2: minor improvements,
references adde
Modification of as-cast Al-Mg/B4C composite by addition of Zr
Zirconium was used in Al-Mg/B4C composite to improve compocasting efficiency by increasing particle incorporation. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) results revealed that by addition of zirconium a reaction layer containing Zr, Al, B and C is formed on the interface of B4C-matrix. X-ray diffraction (XRD) analysis of extracted particles unveiled that the ZrB2 phase is the main constituent of this layer. Formation of ZrB2 is an exothermic reaction which can rise temperature locally around particles and agglomerates. Rising temperature around agglomerates in conjunction with turbulent flow of melt facilitates agglomerates wetting and dissolving into molten aluminum. As the result, final product contains more uniformly distributed B4C particles. Besides enhancing compocasting efficiency, addition of Zr and formation of reaction layer by improving particle matrix bonding quality, led to increase in ultimate tensile strength and elongation of the composite around 8% and 30%, respectively. SEM observations of the fracture surfaces confirmed that a proper bonding presents at the interface of particles and matrix in presence of Zr.Peer ReviewedPostprint (author's final draft
Shave excision of facial tumors in tuberous sclerosis.
Tuberous sclerosis can manifest itself by multiple facial nodules affecting primarily the nose, cheeks, chin, and the nasolabial folds. A simple tangential (shave) excision of these facial tumors is believed to be adequate treatment for some patients
âSmartâ sustainable urban regeneration: Institutions, quality and financial innovation
Cities around the world are under pressure from population growth, frenetic global economic restructuring, and climatic perturbations. Some, like London, attract an excess of speculative, momentum or
tax-informed inward investment to finance their intensification. Provincial towns, on the other hand,
which sustain extractive metropolii, can wither without capital or talent. Sensible planning and calibrated regional investment is the antidote to polarisation but confronts an apparent âsmartâ or âsustainableâ conundrum. Grandiose, technical megaprojects like Songdo or Masdar cities and sprawling,
disconnected estates are an anathema. We articulate a putative smart and sustainable solution
(âsmart-SURâ) with âinstitutionalâ, âprojectâ and innovative âfundingâ components and explore
mega-urban regeneration projects in the UK and Holland. Smart-SUR has geographical, procedural and
teleological aspects. Its mechanism involves local engagement, institutional strengthening, tight project
screening and innovative regenerative funding. Its outcome are inclusive, measured, and coordinated
transformations which âsweatâ existing assets, counter the long-tail of educational failure, and catalyse
productive local innovation
Asynchronous Execution of Python Code on Task Based Runtime Systems
Despite advancements in the areas of parallel and distributed computing, the
complexity of programming on High Performance Computing (HPC) resources has
deterred many domain experts, especially in the areas of machine learning and
artificial intelligence (AI), from utilizing performance benefits of such
systems. Researchers and scientists favor high-productivity languages to avoid
the inconvenience of programming in low-level languages and costs of acquiring
the necessary skills required for programming at this level. In recent years,
Python, with the support of linear algebra libraries like NumPy, has gained
popularity despite facing limitations which prevent this code from distributed
runs. Here we present a solution which maintains both high level programming
abstractions as well as parallel and distributed efficiency. Phylanx, is an
asynchronous array processing toolkit which transforms Python and NumPy
operations into code which can be executed in parallel on HPC resources by
mapping Python and NumPy functions and variables into a dependency tree
executed by HPX, a general purpose, parallel, task-based runtime system written
in C++. Phylanx additionally provides introspection and visualization
capabilities for debugging and performance analysis. We have tested the
foundations of our approach by comparing our implementation of widely used
machine learning algorithms to accepted NumPy standards
A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.
Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire tolerance to antifungal drugs and for nonmeiotic ploidy reduction after mating. We discovered that the ancestor of C. albicans and 2 related pathogens evolved a variant of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kinase, a key regulator of chromosome segregation. Using engineered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the fidelity of chromosome segregation and the rate of acquisition of tolerance to antifungal drugs via aneuploidy. Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. We conclude that genetically programmed and environmentally induced changes in chromatin can confer the capacity for enhanced evolvability via chromosome missegregation
Decay Modes of Unstable Strings in Plane-Wave String Field Theory
The cubic interaction vertex of light-cone string field theory in the
plane-wave background has a simple effective form when considering states with
only bosonic excitations. This simple effective interaction vertex is used in
this paper to calculate the three string interaction matrix elements for states
of arbitrary bosonic excitation and these results are used to examine certain
decay modes on the mass-shell. It is shown that the matrix elements of one
string to two string decays involving only bosonic excitations will vanish to
all orders in 1/mu on the mass-shell when the number of excitations on the
initial string is less than or equal to two, but in general will not vanish
when the number of excitations is greater than two. Also, a truncated
calculation of the mass-shell matrix elements for one string to three string
decays of two excitation states is performed and suggests that these matrix
elements do not vanish on the mass-shell. There is, however, a quantitative
discrepancy between this last result and its (also non-vanishing) gauge theory
prediction from the BMN correspondence.Comment: 11 pages; v2: references added; v3: normalization of interaction
vertex and corresponding amplitudes changed by a factor of mu to reflect SFT
normalization (must now divide by mu to compare with BMN dual gauge theory),
and minor errors correcte
A Scalable Correlator Architecture Based on Modular FPGA Hardware, Reuseable Gateware, and Data Packetization
A new generation of radio telescopes is achieving unprecedented levels of
sensitivity and resolution, as well as increased agility and field-of-view, by
employing high-performance digital signal processing hardware to phase and
correlate large numbers of antennas. The computational demands of these imaging
systems scale in proportion to BMN^2, where B is the signal bandwidth, M is the
number of independent beams, and N is the number of antennas. The
specifications of many new arrays lead to demands in excess of tens of PetaOps
per second.
To meet this challenge, we have developed a general purpose correlator
architecture using standard 10-Gbit Ethernet switches to pass data between
flexible hardware modules containing Field Programmable Gate Array (FPGA)
chips. These chips are programmed using open-source signal processing libraries
we have developed to be flexible, scalable, and chip-independent. This work
reduces the time and cost of implementing a wide range of signal processing
systems, with correlators foremost among them,and facilitates upgrading to new
generations of processing technology. We present several correlator
deployments, including a 16-antenna, 200-MHz bandwidth, 4-bit, full Stokes
parameter application deployed on the Precision Array for Probing the Epoch of
Reionization.Comment: Accepted to Publications of the Astronomy Society of the Pacific. 31
pages. v2: corrected typo, v3: corrected Fig. 1
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