Study of antioxidant property of a thiosphorated compound derived from cashew nut shell liquid in hydrogenated naphthenics oils

The present work shows the aspects related to the synthesis and thermogravimetric analysis of thiophosphorated and phosphorated compounds from hydrogenated cardanol. Studies on thermal-oxidative stability were investigated, using a classical thermoanalytical-thermogravimetric method (TG/DTG) in an air atmosphere. Its use as an antioxidant additive in hydrogenated naphthenic NH10, NH20 and NH140 oils was evaluated. The addition of 1.2% synthesized compounds to the oils has improved their thermal-oxidative stability by 5-15ºC. The occurrence of major thermal degradation events at higher temperatures (Tmax) in additivated oils is a good indication of the antioxidant properties of the thiophosphorated and phosphorated cardanol compounds antioxidant properties

A Greener Approach for the Large-Scale Synthesis of 1,4,5-Trisubstituted Pyrazole, AZD8329

The development of a convenient, safe and scalable process for <b>AZD8329</b> manufacturing is reported here. Synthesis was achieved in a two-step telescopic process with an excellent overall yield of 75%. In the first step enamine (<b>6</b>) was synthesized with 90% yield through three chemical transformations. In the next step <b>AZD8329</b> was synthesized from the reactions of <b>6</b> and 4-hydrazinobenzoic acid hydrochloride <b>7</b> through two chemical transformations. The process is very efficient and economical, and <b>AZD8329</b> was manufactured in multikilogram scale. A greener approach is demonstrated through usage of a minimum number of solvents and energy and with process mass intensity (PMI) <60 in the manufacturing process