636 research outputs found
Metabotropic glutamate 2/3 receptors and epigenetic modifications in psychotic disorders: a review
Schizophrenia and Bipolar Disorder are chronic psychiatric disorders, both considered as "major psychosis"; they are thought to share some pathogenetic factors involving a dysfunctional gene x environment interaction. Alterations in the glutamatergic transmission have been suggested to be involved in the pathogenesis of psychosis. Our group developed an epigenetic model of schizophrenia originated by Prenatal Restraint Stress (PRS) paradigm in mice. PRS mice developed some behavioral alterations observed in schizophrenic patients and classic animal models of schizophrenia, i.e. deficits in social interaction, locomotor activity and prepulse inhibition. They also showed specific changes in promoter DNA methylation activity of genes related to schizophrenia such as reelin, BDNF and GAD67, and altered expression and function of mGlu2/3 receptors in the frontal cortex. Interestingly, behavioral and molecular alterations were reversed by treatment with mGlu2/3 agonists. Based on these findings, we speculate that pharmacological modulation of these receptors could have a great impact on early phase treatment of psychosis together with the possibility to modulate specific epigenetic key protein involved in the development of psychosis. In this review, we will discuss in more details the specific features of the PRS mice as a suitable epigenetic model for major psychosis. We will then focus on key proteins of chromatin remodeling machinery as potential target for new pharmacological treatment through the activation of metabotropic glutamate receptors
Three-Dimensional Electronic Structure of type-II Weyl Semimetal WTe
By combining bulk sensitive soft-X-ray angular-resolved photoemission
spectroscopy and accurate first-principles calculations we explored the bulk
electronic properties of WTe, a candidate type-II Weyl semimetal featuring
a large non-saturating magnetoresistance. Despite the layered geometry
suggesting a two-dimensional electronic structure, we find a three-dimensional
electronic dispersion. We report an evident band dispersion in the reciprocal
direction perpendicular to the layers, implying that electrons can also travel
coherently when crossing from one layer to the other. The measured Fermi
surface is characterized by two well-separated electron and hole pockets at
either side of the point, differently from previous more surface
sensitive ARPES experiments that additionally found a significant quasiparticle
weight at the zone center. Moreover, we observe a significant sensitivity of
the bulk electronic structure of WTe around the Fermi level to electronic
correlations and renormalizations due to self-energy effects, previously
neglected in first-principles descriptions
Electronic Structure of CeFeAsO1-xFx (x=0, 0.11/x=0.12) compounds
We report an extensive study on the intrinsic bulk electronic structure of
the high-temperature superconductor CeFeAsO0.89F0.11 and its parent compound
CeFeAsO by soft and hard x-ray photoemission, x-ray absorption and soft-x-ray
emission spectroscopies. The complementary surface/bulk probing depth, and the
elemental and chemical sensitivity of these techniques allows resolving the
intrinsic electronic structure of each element and correlating it with the
local structure, which has been probed by extended-x-ray absorption fine
structure spectroscopy. The measurements indicate a predominant 4f1 (i.e. Ce3+)
initial state configuration for Cerium and an effective valence-band-to-4f
charge-transfer screening of the core hole. The spectra also reveal the
presence of a small Ce f0 initial state configuration, which we assign to the
occurrence of an intermediate valence state. The data reveal a reasonably good
agreement with the partial density of states as obtained in standard density
functional calculations over a large energy range. Implications for the
electronic structure of these materials are discussed.Comment: Accepted for publication in Phys. Rev.
Analysis of Metal-Insulator Crossover in Strained {SrRuO}3 Thin Films by X-ray Photoelectron Spectroscopy
The electronic properties of ultrathin epitaxial films of strontium ruthenate SrRuO3 perovskite oxide are modified by epitaxial strain, as determined by growing by pulsed laser deposition, on different the substrates. Electron transport measurements indicated that tensile strain deformation of the SrRuO3 unit cell reduces the metallicity of the material and reduces the metal-insulator-transition (MIT) temperatures. The shrinkage of the Ru-O-Ru buckling angle due to compressive strain is counterweighted by the increased overlap of the conduction Ru-4d orbitals with the O-2p ones due to the smaller interatomic distances resulting into an increased MIT temperature, i.e. a more conducting material. In the more metallic samples the core level x-ray photoemission spectroscopy lineshapes show the occurrence of an extra-peak at the lower binding energies of the main Ru-3d peaks that is attributed to screening, as observed in volume sensitive photoemission of the unstrained material
Anisotropic hybridization probed by polarization dependent x-ray absorption spectroscopy in VI3 van der Waals Mott ferromagnet
Polarization dependent x-ray absorption spectroscopy was used to study the
magnetic ground state and the orbital occupation in bulk-phase VI van der
Waals crystals below and above the ferromagnetic and structural transitions.
X-ray natural linear dichroism and X-ray magnetic circular dichroism spectra
acquired at the V edges are compared against multiplet cluster
calculations within the frame of the ligand field theory to quantify the
intra-atomic electronic interactions at play and evaluate the effects of
symmetry reduction occurring in a trigonally distorted VI unit. We observed
a non zero linear dichroism proving the presence of an anisotropic charge
density distribution around the V ion due to the unbalanced
hybridization between the Vanadium and the ligand states. Such hybridization
acts as an effective trigonal crystal field, slightly lifting the degeneracy of
the ground state. However, the energy splitting associated to the
distortion underestimates the experimental band gap, suggesting that the
insulating ground state is stabilized by Mott correlation effects rather than
via a Jahn-Teller mechanism. Our results clarify the role of the distortion in
VI and establish a benchmark for the study of the spectroscopic properties
of other van der Waals halides, including emerging 2D materials with mono and
few-layers thickness, whose fundamental properties might be altered by reduced
dimensions and interface proximity
- …