Near-Extreme Black Holes and the Universal Relaxation Bound

A fundamental bound on the relaxation time \tau of a perturbed thermodynamical system has recently been derived, \tau \geq \hbar/\pi T, where $T$ is the system's temperature. We demonstrate analytically that black holes saturate this bound in the extremal limit and for large values of the azimuthal number m of the perturbation field.Comment: 2 Pages. Submitted to PRD on 5/12/200

Time's Barbed Arrow: Irreversibility, Crypticity, and Stored Information

We show why the amount of information communicated between the past and future--the excess entropy--is not in general the amount of information stored in the present--the statistical complexity. This is a puzzle, and a long-standing one, since the latter is what is required for optimal prediction, but the former describes observed behavior. We layout a classification scheme for dynamical systems and stochastic processes that determines when these two quantities are the same or different. We do this by developing closed-form expressions for the excess entropy in terms of optimal causal predictors and retrodictors--the epsilon-machines of computational mechanics. A process's causal irreversibility and crypticity are key determining properties.Comment: 4 pages, 2 figure

Specific protein-protein binding in many-component mixtures of proteins

Proteins must bind to specific other proteins in vivo in order to function. The proteins must bind only to one or a few other proteins of the of order a thousand proteins typically present in vivo. Using a simple model of a protein, specific binding in many component mixtures is studied. It is found to be a demanding function in the sense that it demands that the binding sites of the proteins be encoded by long sequences of bits, and the requirement for specific binding then strongly constrains these sequences. This is quantified by the capacity of proteins of a given size (sequence length), which is the maximum number of specific-binding interactions possible in a mixture. This calculation of the maximum number possible is in the same spirit as the work of Shannon and others on the maximum rate of communication through noisy channels.Comment: 13 pages, 3 figures (changes for v2 mainly notational - to be more in line with notation in information theory literature

Cyclic exchange, isolated states and spinon deconfinement in an XXZ Heisenberg model on the checkerboard lattice

The antiferromagnetic Ising model on a checkerboard lattice has an ice-like ground state manifold with extensive degeneracy. and, to leading order in J_xy, deconfined spinon excitations. We explore the role of cyclic exchange arising at order J^2_xy/J_z on the ice states and their associated spinon excitations. By mapping the original problem onto an equivalent quantum six--vertex model, we identify three different phases as a function of the chemical potential for flippable plaquettes - a phase with long range Neel order and confined spinon excitations, a non-magnetic state of resonating square plaquettes, and a quasi-collinear phase with gapped but deconfined spinon excitations. The relevance of the results to the square--lattice quantum dimer model is also discussed.Comment: 4 pages, 5 figure

APRIL:TACI axis is dispensable for the immune response to rabies vaccination.

There is significant need to develop a single-dose rabies vaccine to replace the current multi-dose rabies vaccine regimen and eliminate the requirement for rabies immune globulin in post-exposure settings. To accomplish this goal, rabies virus (RABV)-based vaccines must rapidly activate B cells to secrete antibodies which neutralize pathogenic RABV before it enters the CNS. Increased understanding of how B cells effectively respond to RABV-based vaccines may improve efforts to simplify post-exposure prophylaxis (PEP) regimens. Several studies have successfully employed the TNF family cytokine a proliferation-inducing ligand (APRIL) as a vaccine adjuvant. APRIL binds to the receptors TACI and B cell maturation antigen (BCMA)-expressed by B cells in various stages of maturation-with high affinity. We discovered that RABV-infected primary murine B cells upregulate APRIL ex vivo. Cytokines present at the time of antigen exposure affect the outcome of vaccination by influencing T and B cell activation and GC formation. Therefore, we hypothesized that the presence of APRIL at the time of RABV-based vaccine antigen exposure would support the generation of protective antibodies against RABV glycoprotein (G). In an effort to improve the response to RABV vaccination, we constructed and characterized a live recombinant RABV-based vaccine vector which expresses murine APRIL (rRABV-APRIL). Immunogenicity testing in mice demonstrated that expressing APRIL from the RABV genome does not impact the primary antibody response against RABV G compared to RABV alone. In order to evaluate the necessity of APRIL for the response to rabies vaccination, we compared the responses of APRIL-deficient and wild-type mice to immunization with rRABV. APRIL deficiency does not affect the primary antibody response to vaccination. Furthermore, APRIL expression by the vaccine did not improve the generation of long-lived antibody-secreting plasma cells (PCs) as serum antibody levels were equivalent in response to rRABV-APRIL and the vector eight weeks after immunization. Moreover, APRIL is dispensable for the long-lived antibody-secreting PC response to rRABV vaccination as anti-RABV G IgG levels were similar in APRIL-deficient and wild-type mice six months after vaccination. Mice lacking the APRIL receptor TACI demonstrated primary anti-RABV G antibody responses similar to wild-type mice following immunization with the vaccine vector indicating that this response is independent of TACI-mediated signals. Collectively, our findings demonstrate that APRIL and associated TACI signaling is dispensable for the immune response to RABV-based vaccination

Lossless quantum data compression and variable-length coding

In order to compress quantum messages without loss of information it is necessary to allow the length of the encoded messages to vary. We develop a general framework for variable-length quantum messages in close analogy to the classical case and show that lossless compression is only possible if the message to be compressed is known to the sender. The lossless compression of an ensemble of messages is bounded from below by its von-Neumann entropy. We show that it is possible to reduce the number of qbits passing through a quantum channel even below the von-Neumann entropy by adding a classical side-channel. We give an explicit communication protocol that realizes lossless and instantaneous quantum data compression and apply it to a simple example. This protocol can be used for both online quantum communication and storage of quantum data.Comment: 16 pages, 5 figure

Non-additivity of quantum capacity for multiparty communication channels

We investigate multiparty communication scenarios where information is sent from several sender to several receivers. We establish a relation between the quantum capacity of multiparty communication channels and their distillability properties which enables us to show that the quantum capacity of such channels is not additive.Comment: 4 pages, 1 figur

Thermodynamic time asymmetry in nonequilibrium fluctuations

We here present the complete analysis of experiments on driven Brownian motion and electric noise in a $RC$ circuit, showing that thermodynamic entropy production can be related to the breaking of time-reversal symmetry in the statistical description of these nonequilibrium systems. The symmetry breaking can be expressed in terms of dynamical entropies per unit time, one for the forward process and the other for the time-reversed process. These entropies per unit time characterize dynamical randomness, i.e., temporal disorder, in time series of the nonequilibrium fluctuations. Their difference gives the well-known thermodynamic entropy production, which thus finds its origin in the time asymmetry of dynamical randomness, alias temporal disorder, in systems driven out of equilibrium.Comment: to be published in : Journal of Statistical Mechanics: theory and experimen

The protein information and property explorer: an easy-to-use, rich-client web application for the management and functional analysis of proteomic data

Motivation: Mass spectrometry experiments in the field of proteomics produce lists containing tens to thousands of identified proteins. With the protein information and property explorer (PIPE), the biologist can acquire functional annotations for these proteins and explore the enrichment of the list, or fraction thereof, with respect to functional classes. These protein lists may be saved for access at a later time or different location. The PIPE is interoperable with the Firegoose and the Gaggle, permitting wide-ranging data exploration and analysis. The PIPE is a rich-client web application which uses AJAX capabilities provided by the Google Web Toolkit, and server-side data storage using Hibernate. Availability: http://pipe.systemsbiology.net Contact: [email protected]

Are multiphase competition & order-by-disorder the keys to understanding Yb2Ti2O7?

If magnetic frustration is most commonly known for undermining long-range order, as famously illustrated by spin liquids, the ability of matter to develop new collective mechanisms in order to fight frustration is no less fascinating, providing an avenue for the exploration and discovery of unconventional properties of matter. Here we study an ideal minimal model of such mechanisms which, incidentally, pertains to the perplexing quantum spin ice candidate Yb2Ti2O7. Specifically, we explain how thermal and quantum fluctuations, optimized by order-by-disorder selection, conspire to expand the stability region of an accidentally degenerate continuous symmetry U(1) manifold against the classical splayed ferromagnetic ground state that is displayed by the sister compound Yb2Sn2O7. The resulting competition gives rise to multiple phase transitions, in striking similitude with recent experiments on Yb2Ti2O7 [Lhotel et al., Phys. Rev. B 89 224419 (2014)]. Considering the effective Hamiltonian determined for Yb2Ti2O7, we provide, by combining a gamut of numerical techniques, compelling evidence that such multiphase competition is the long-sought missing key to understanding the intrinsic properties of this material. As a corollary, our work offers a pertinent illustration of the influence of chemical pressure in rare-earth pyrochlores.Comment: 9 page