Effects of crude ethanolic extract of Garcinia cambogia on the reproductive system of male wist ar rats (Rattus novergicus)

15 male rats were grouped and administered crude ethanolic extracts of Garcinia cambogia seeds to test the effects on the histology of the testis and sperm counts. Group A served as the control while Groups B and C received 100 and 200 mg/kg body weight of extracts, respectively. The administration was done orally once a day, six days a week for six weeks. The routine histological preparation at the end of administration revealed increase in the interstitial spaces, degeneration of the Ledgid cells and distortion in the arrangement of the cells of spermatogenic series. The sperm counts revealed a significant increase in the experimental groups when compared statistically with the control (p<0.05). It was 81.5 ± 13.62 ´ 10^6/ml and 70 ± 12.98 ´ 10^6 /ml in groups Band C, respectively, as compared to 59.8 ± 2.14 ´ 10^6/ml in the Control group

Tanzanian lessons in using non-physician clinicians to scale up comprehensive emergency obstetric care in remote and rural areas

UNLABELLED\ud \ud ABSTRACT:\ud \ud BACKGROUND\ud \ud With 15-30% met need for comprehensive emergency obstetrical care (CEmOC) and a 3% caesarean section rate, Tanzania needs to expand the number of facilities providing these services in more remote areas. Considering severe shortage of human resources for health in the country, currently operating at 32% of the required skilled workforce, an intensive three-month course was developed to train non-physician clinicians for remote health centres.\ud \ud METHODS\ud \ud Competency-based curricula for assistant medical officers' (AMOs) training in CEmOC, and for nurses, midwives and clinical officers in anaesthesia and operation theatre etiquette were developed and implemented in Ifakara, Tanzania. The required key competencies were identified, taught and objectively assessed. The training involved hands-on sessions, lectures and discussions. Participants were purposely selected in teams from remote health centres where CEmOC services were planned. Monthly supportive supervision after graduation was carried out in the upgraded health centres\ud \ud RESULTS\ud \ud A total of 43 care providers from 12 health centres located in 11 rural districts in Tanzania and 2 from Somalia were trained from June 2009 to April 2010. Of these 14 were AMOs trained in CEmOC and 31 nurse-midwives and clinical officers trained in anaesthesia. During training, participants performed 278 major obstetric surgeries, 141 manual removal of placenta and evacuation of incomplete and septic abortions, and 1161 anaesthetic procedures under supervision. The first 8 months after introduction of CEmOC services in 3 health centres resulted in 179 caesarean sections, a remarkable increase of institutional deliveries by up to 300%, decreased fresh stillbirth rate (OR: 0.4; 95% CI: 0.1-1.7) and reduced obstetric referrals (OR: 0.2; 95% CI: 0.1-0.4)). There were two maternal deaths, both arriving in a moribund condition.\ud \ud CONCLUSIONS\ud \ud Tanzanian AMOs, clinical officers, and nurse-midwives can be trained as a team, in a three-month course, to provide effective CEmOC and anaesthesia in remote health centres

Maternal health interventions in resource limited countries: a systematic review of packages, impacts and factors for change

The burden of maternal mortality in resource limited countries is still huge despite being at the top of the global public health agenda for over the last 20 years. We systematically reviewed the impacts of interventions on maternal health and factors for change in these countries. A systematic review was carried out using the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Articles published in the English language reporting on implementation of interventions, their impacts and underlying factors for maternal health in resource limited countries in the past 23 years were searched from PubMed, Popline, African Index Medicus, internet sources including reproductive health gateway and Google, hand-searching, reference lists and grey literature. Out of a total of 5084 articles resulting from the search only 58 qualified for systematic review. Programs integrating multiple interventions were more likely to have significant positive impacts on maternal outcomes. Training in emergency obstetric care (EmOC), placement of care providers, refurbishment of existing health facility infrastructure and improved supply of drugs, consumables and equipment for obstetric care were the most frequent interventions integrated in 52%-65% of all 54 reviewed programs. Statistically significant reduction of maternal mortality ratio and case fatality rate were reported in 55% and 40% of the programs respectively. Births in EmOC facilities and caesarean section rates increased significantly in 71%-75% of programs using these indicators. Insufficient implementation of evidence-based interventions in resources limited countries was closely linked to a lack of national resources, leadership skills and end-users factors. This article presents a list of evidenced-based packages of interventions for maternal health, their impacts and factors for change in resource limited countries. It indicates that no single magic bullet intervention exists for reduction of maternal mortality and that all interventional programs should be integrated in order to bring significant changes. State leaders and key actors in the health sectors in these countries and the international community are proposed to translate the lessons learnt into actions and intensify efforts in order to achieve the goals set for maternal health

Texting and driving among drivers in Trinidad and Tobago, West Indies

The use of a mobile phone to text messages while driving has been recognised as a high risk behaviour. The objective of this study was to determine the self-reported texting behaviour of motor vehicle drivers in Trinidad and Tobago and the factors that predict texting by the drivers. This study was part of a larger cross-sectional study on road safety of 1500 motor vehicle drivers. Data were collected using a self-administered questionnaire. Data analysis was done using descriptive statistics, Chi square test and multinomial logistic regression analysis. Majority of the drivers (94.5%) reported that texting while driving is either very dangerous or moderately dangerous. However, just over half of the drivers (51.6%) always or sometimes texted messages while driving. The drivers reduced their speed (49.5%), stopped the vehicle (19.8%), drove in the slow lane or road shoulder (14.1%) or made no changes whatsoever (16.6%) when texting and driving. The predictors of the drivers, who were less likely to sometimes text messages when driving, were their age, years they have been driving and their perception of texting and driving as hazardous. The predictors of the drivers, who were less likely to always text messages when driving, were their age, marital status and their perception of texting and driving as hazardous. There is a high level of texting while driving by the drivers in Trinidad and Tobago, despite the fact that a majority of these drivers perceived this practice to be a road safety hazard.Keywords: Texting, driving, mobile phones, Trinidad and Tobago, West Indies

Immune system investigation using parasitic helminths

Coevolutionary adaptation between humans and helminths has developed a finely tuned balance between host immunity and chronic parasitism due to immunoregulation. Given that these reciprocal forces drive selection, experimental models of helminth infection are ideally suited for discovering how host protective immune responses adapt to the unique tissue niches inhabited by these large metazoan parasites. This review highlights the key discoveries in the immunology of helminth infection made over the last decade, from innate lymphoid cells to the emerging importance of neuroimmune connections. A particular emphasis is placed on the emerging areas within helminth immunology where the most growth is possible, including the advent of genetic manipulation of parasites to study immunology and the use of engineered T cells for therapeutic options. Lastly,we cover the status of human challenge trials with helminths as treatment for autoimmune disease, which taken together, stand to keep the study of parasitic worms at the forefront of immunology for years to come