DISC1 genetics, biology and psychiatric illness

Psychiatric disorders are highly heritable, and in many individuals likely arise from the combined effects of genes and the environment. A substantial body of evidence points towards DISC1 being one of the genes that influence risk of schizophrenia, bipolar disorder and depression, and functional studies of DISC1 consequently have the potential to reveal much about the pathways that lead to major mental illness. Here, we review the evidence that DISC1 influences disease risk through effects upon multiple critical pathways in the developing and adult brain

Global migration of influenza A viruses in swine

The complex and unresolved evolutionary origins of the 2009 H1N1 influenza pandemic exposed major gaps in our knowledge of the global spatial ecology and evolution of influenza A viruses in swine (swIAVs). Here we undertake an expansive phylogenetic analysis of swIAV sequence data and demonstrate that the global live swine trade strongly predicts the spatial dissemination of swIAVs, with Europe and North America acting as sources of viruses in Asian countries. In contrast, China has the world's largest swine population but is not a major exporter of live swine, and is not an important source of swIAVs in neighbouring Asian countries or globally. A meta-population simulation model incorporating trade data predicts that the global ecology of swIAVs is more complex than previously thought, and the United States and China's large swine populations are unlikely to be representative of swIAV diversity in their respective geographic regions, requiring independent surveillance efforts throughout Latin America and Asia.status: publishe

Description of Anopheles (Nyssorhynchus) dunhami, a new species from the upper Amazon Basin.

Ministério da Educação e Saúde. Serviço Especial de Saúde Pública. Instituto Evandro Chagas. Belém, PA, Brasil.A new species, Anofheles (Nyssorhynchus) dunhami, is described from Tefé, Amazonas, Brazil, in a region where malária is not prevalent. By egg, larva and adult color pattern it is similar toAnopheles goeldii. The male terminali distinguish it from both Anopheles goeldii and Anophele nunez-tovari

Procedência dos arborvírus isolados de 1954 a 1957 em Belém (Publicado originalmente em 1958)

Ministério da Educação e Saúde. Serviço Especial de Saúde Pública. Instituto Evandro. Belém, PA, Brasil / Fundação Rockefeller

The isolation of virus from natural and sentinel hosts in the Amazon valley (Publicado originalmente em 1962)

Ministério da Educação e Saúde. Serviço Especial de Saúde Pública. Instituto Evandro. Belém, PA, Brasil.Uma revisão dos seis anos de atividade do Laboratório de Vírus de Belém, mostra que, na área estudada, o camundongo infante sentinela proporciona o meio mais eficiente para constatar a atividade de arbovírus. Tôdas as fontes naturais, todavia, incluindo vertebrados doentes, animais silvestres e artrópodos vetores contribuem para um compreensivo reconhecimento dos vírus presentes na região

American Journal of Tropical Medicine and Hygiene, Manuscript Reviews -- 1958-62 -- Professional Affiliations and Memberships, Correspondence (Journals) -- text, 1958-12-17

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Description of Anopheles (Nyssorhynchus) dunhami, a new species from the upper Amazon basin

Publicado originalmente em Journal of the National Malaria Society, v. 4, n. 3, p. 231-234, sept. 1945Serviço Especial de Saúde Publica. Belém, PA, Brasil / Inter-American AffairsA new species, Anopheles (Nyssorhynchus) dunhami, is described from Tefé, Amazonas, Brazil, in a region where malaria is not prevalent. By egg, larva and adult color pattern it is similar to Anopheles goeldii. The male terminali distinguish it from both Anopheles goeldii and Anophele nunez-tovari