Searching for "monogenic diabetes" in dogs using a candidate gene approach

BACKGROUND: Canine diabetes is a common endocrine disorder with an estimated breed-related prevalence ranging from 0.005% to 1.5% in pet dogs. Increased prevalence in some breeds suggests that diabetes in dogs is influenced by genetic factors and similarities between canine and human diabetes phenotypes suggest that the same genes might be associated with disease susceptibility in both species. Between 1-5% of human diabetes cases result from mutations in a single gene, including maturity onset diabetes of the adult (MODY) and neonatal diabetes mellitus (NDM). It is not clear whether monogenic forms of diabetes exist within some dog breeds. Identification of forms of canine monogenic diabetes could help to resolve the heterogeneity of the condition and lead to development of breed-specific genetic tests for diabetes susceptibility. RESULTS: Seventeen dog breeds were screened for single nucleotide polymorphisms (SNPs) in eighteen genes that have been associated with human MODY/NDM. Six SNP associations were found from five genes, with one gene (ZFP57) being associated in two different breeds. CONCLUSIONS: Some of the genes that have been associated with susceptibility to MODY and NDM in humans appear to also be associated with canine diabetes, although the limited number of associations identified in this study indicates canine diabetes is a heterogeneous condition and is most likely to be a polygenic trait in most dog breeds. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/2052-6687-1-8) contains supplementary material, which is available to authorized users

Promoting a Culturally Safe Evaluation of an On-the-Land Wellness Program in the Inuvialuit Settlement Region

In 2017, the Inuvialuit Regional Corporation partnered with a diverse research advisory team to understand how Project Jewel, a land-based program in the Inuvialuit Settlement Region, could be evaluated in a way that promotes cultural safety (i.e., in a way that addresses the social, historical, and economic contexts that shape participants’ experiences). We used community-based research methodology to approach the study, through which semi-structured interviews, sharing circles, and photovoice were identified by the community advisory board and research advisory team as appropriate research methods for this project. After piloting and evaluating these methods, we then used thematic analysis to analyze the data, which included images and transcripts, to identify the components of a culturally safe evaluation: centring the land, building relationships, working with words and pictures, and promoting benefit over harms through program aftercare. Our community-based research and findings provide a template of a meaningful evaluation framework that other on-the-land programs can use if contextualized within local cultural practices and values.En 2017, l’Inuvialuit Regional Corporation s’est associée à une équipe de recherche consultative diversifiée pour tâcher de comprendre comment le projet Jewel, programme terrestre mené à bien dans la région désignée des Inuvialuit, pourrait être évalué de manière à favoriser la sécurité ou sécurisation culturelle (c’est-à-dire de manière à tenir compte des contextes social, historique et économique ayant façonné les expériences des participants). Nous nous sommes servis d’une méthodologie de recherche communautaire pour aborder l’étude. Grâce à cette méthodologie, le conseil consultatif communautaire et l’équipe de recherche consultative ont déterminé que des entrevues semi-structurées, des cercles de partage et des recherches par amorce photo étaient des méthodes de recherche convenant bien à ce projet. Après avoir mis ces méthodes à l’essai et les avoir évaluées, nous avons recouru à une analyse thématique pour analyser les données, comprenant des images et des transcriptions, afin d’aboutir aux composantes d’une évaluation tenant compte de la sécurité culturelle, soit : centrer la terre, nouer des relations, travailler avec des mots et des images, et mettre l’accent sur les bienfaits par opposition aux méfaits en faisant le suivi du programme. Notre recherche communautaire et les constatations qui en découlent ont permis de mener à un modèle de cadre d’évaluation utile dont d’autres programmes terrestres peuvent se servir pourvu qu’ils le contextualisent en fonction des pratiques et des valeurs culturelles locales

Swearing at Work: The Mixed Outcomes of Profanity

We explore the use and misuse of swearing in the workplace. Using a qualitative methodology, we interviewed 52 lawyers, medical doctors and business executives in the UK, France, and the U.S. In contrast to much of the incivility and social norms literatures, we find that male and female business executives, lawyers and doctors of all ages admit to swearing. Further, swearing can lead to positive outcomes at the individual, interpersonal and group levels, including stress-relief, communication-enrichment, and socialization-enhancement. An implication for future scholarship is that ‘thinking out of the box’ when exploring emotion related issues can lead to new insights. Practical implications include reconsidering and tolerating incivility under certain conditions. We identified a case in which a negative phenomenon reveals counter-intuitive yet insightful results

Sedimentation record in the Konkan-Kerala Basin: implications for the evolution of the Western Ghats and the Western Indian passive margin

The Konkan and Kerala Basins constitute a major depocentre for sediment from the onshore hinterland of Western India and as such provide a valuable record of the timing and magnitude of Cenozoic denudation along the continental margin. This paper presents an analysis of sedimentation in the Konkan-Kerala Basin, coupledwith a mass balance study, and numerical modelling of flexural responses to onshore denudational unloading and o¡shore sediment loading in order to test competing conceptual models for the development of high-elevation passive margins. The Konkan-Kerala Basin contains an estimated 109,000 km<sup>3</sup>; of Cenozoic clastic sediment, a volume difficult to reconcile with the denudation of a downwarped rift flank onshore, and more consistent with denudation of an elevated rift flank. We infer from modelling of the isostatic response of the lithosphere to sediment loading offshore and denudation onshore that flexure is an important component in the development of the Western Indian Margin.There is evidence for two major pulses in sedimentation: an early phase in the Palaeocene, and a second beginning in the Pliocene. The Palaeocene increase in sedimentation can be interpreted in terms of a denudational response to the rifting between India and the Seychelles, whereas the mechanism responsible for the Pliocene pulse is more enigmatic

Exploring the performance of the spectrometer prisma in heavy zirconium and xenon mass regions

We present results from two recent runs which illustrate the performance of the PRISMA spectrometer in the proximity of the upper limit of its operational interval, namely 96Zr + 124Sn at Elab = 500 MeV and 136Xe + 208Pb at Elab = 930 MeV. In the latter run, the γ array CLARA also allowed us to identify previously unknown γ transitions in the nuclides 136Cs and 134I

Thresholds : Gesture, idea and action in the Performance Art of Andrew Drummond, Di ffrench and David Mealing

This thesis examines the work of three New Zealand artists who engaged with processes of performance art during the 1970s and 1980s. David Mealing, Andrew Drummond and Di ffrench integrated performance gestures that mutated into object or conceptual based practices in the 1980s and 1990s. An analysis of their work reveals both similarities and differences, all adjacent to corporeal, political and aesthetic issues and ideas that stem from international and national events particular to the milieu in which they worked. The three artists stand apart from their contemporaries due to their focussed positions as socio-political commentators during a turbulent time in New Zealand history. A large body of written and oral research on their work provides an historical view of the period from 1969 - 1999 that will focus specifically on their aesthetic experimentation and concerns with the fragmentation of the body, self and identity, and, importantly, their intended use of art to effect change. Performance art in New Zealand underwent a burst of energy from 1969 as time-based activity offered an alternative to the static painterly or totemic art practices, as found in much international late modernism. Mealing, Drummond and ffrench explored a notion of performance art that resided in and beyond the margins of mainstream activity. A concept of the limen or the margin, the threshold and the littoral zone - a metaphorical place of creativity is applied to this analysis of their work. These individuals expressed through ritual and symbol found in notions of the-limen, socio-political beliefs that reflected a view of artistic responsibility toward pressing issues of identity, freedom of expression, ecological wellbeing and the human condition. Each artist concentrated on phenomenological themes surrounding the body, explored alternative sculptural material and enjoyed instances of imaginative communication. The body trace that evolved from the temporal moment, their relationship to the land and the urban environment, and an intersubjective exchange with the audience were all engaged with. This is articulated in their practices of socio-political interaction, as expressed through Mealing's interventions, a spatial/kinetic continuum, as seen in Drummond's sculptures, and a performative materialisation of difference as evident in the cibachromes of Di ffrench. Historical international precedents of performance art will interweave with this specific New Zealand study in order to further highlight the diversity of performance art that these artists employed in their idiosyncratic journeys along the borderlands of art making

Correction to: Sars-Cov-2 Infection in People with Type 1 Diabetes and Hospital Admission: An Analysis of Risk Factors for England

The article “Sars-Cov-2 Infection in People with Type 1 Diabetes and Hospital Admission: An Analysis of Risk Factors for England”, written by Adrian H. Heald, David A. Jenkins, Richard Williams, Rajshekhar N. Mudaliar, Amber Khan, Akheel Syed, Naveed Sattar, Kamlesh Khunti, Asma Naseem, Kelly A. Bowden-Davies, J. Martin Gibson, William Ollier, on behalf of the CVD-COVID-UK/COVID-IMPACT Consortium was originally published electronically on the publisher’s Internet portal (currently SpringerLink) on August 25, 2023, without open access. Now, the article is updated with open access as This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The original article has been corrected

Sars-Cov-2 Infection in People with Type 1 Diabetes and Hospital Admission: An Analysis of Risk Factors for England

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus (coronavirus disease 2019 [COVID-19]) pandemic revealed the vulnerability of specific population groups in relation to susceptibility to acute deterioration in their health, including hospital admission and mortality. There is less data on outcomes for people with type 1 diabetes (T1D) following SARS-CoV-2 infection than for those with type 2 diabetes (T2D). In this study we set out to determine the relative likelihood of hospital admission following SARS-CoV-2 infection in people with T1D when compared to those without T1D. Methods: This study was conducted as a retrospective cohort study and utilised an all-England dataset. Electronic health record data relating to people in a national England database (NHS England’s Secure Data Environment, accessed via the BHF Data Science Centre's CVD-COVID-UK/COVID-IMPACT consortium) were analysed. The cohort consisted of patients with a confirmed SARS-CoV-2 infection, and the exposure was whether or not an individual had T1D prior to infection (77,392 patients with T1D). The patients without T1D were matched for sex, age and approximate date of the positive COVID-19 test, with three SARS-CoV-2-infected people living without diabetes (n = 223,995). Potential factors influencing the relative likelihood of the outcome of hospital admission within 28 days were ascertained using univariable and multivariable logistic regression. Results: Median age of the people living with T1D was 37 (interquartile range 25–52) years, 47.4% were female and 89.6% were of white ethnicity. Mean body mass index was 27 (standard error [SE] 0.022) kg/m2, and mean glycated haemoglobin (HbA1c) was 67.3 (SE 0.069) mmol/mol (8.3%). A significantly higher proportion of people with T1D (10.7%) versus matched non-diabetes individuals (3.9%) were admitted to hospital. In combined analysis including individuals with T1D and matched controls, multiple regression modelling indicated that the factors independently relating to a higher likelihood of hospital admission were: T1D (odds ratio [OR] 1.71, 95% confidence interval [CI] 1.62–1.80]), age (OR 1.02, 95% CI 1.02–1.03), social deprivation (higher Townsend deprivation score: OR 1.07, 95% CI 1.06–1.08), lower estimated glomerular filtration rate (eGFR) value (OR 0.975, 95% CI 0.974–0.976), non-white ethnicity (OR black 1.19, 95% CI 1.06–1.33/OR Asian 1.21, 95% CI 1.05–1.39) and having asthma (OR 1.27, 95% CI 1.19–1.35]), chronic obstructive pulmonary disease (OR 2.10, 95% CI 1.89–2.32), severe mental illness (OR 1.83, 95% CI 1.57–2.12) or hypertension (OR 1.44, 95% CI 1.37–1.52). Conclusion: In this all-England study, we describe that, following confirmed infection with SARS-CoV-2, the risk factors for hospital admission for people living with T1D are similar to people without diabetes following confirmed SARS-CoV-2 infection, although the former were more likely to be admitted to hospital. The younger age of individuals with T1D in relation to risk stratification must be taken into account in any ongoing risk reduction strategies regarding COVID-19/future viral pandemics