4 research outputs found
Novel Benzamide-Based Histamine H3 Receptor Antagonists: The Identification of Two Candidates for Clinical Development
The
preclinical characterization of novel phenylÂ(piperazin-1-yl)Âmethanones
that are histamine H<sub>3</sub> receptor antagonists is described.
The compounds described are high affinity histamine H<sub>3</sub> antagonists.
Optimization of the physical properties of these histamine H<sub>3</sub> antagonists led to the discovery of several promising lead compounds,
and extensive preclinical profiling aided in the identification of
compounds with optimal duration of action for wake promoting activity.
This led to the discovery of two development candidates for Phase
I and Phase II clinical trials
Data Resource Profile: COVerAGE-DB: a global demographic database of COVID-19 cases and deaths
Riffe T, Acosta E, Aburto JM, et al. Data Resource Profile: COVerAGE-DB: a global demographic database of COVID-19 cases and deaths. International Journal of Epidemiology. 2021;50(2):390-390f