Clinical and functional outcome of elastic stable intramedullary nailing in pediatric femoral fractures in the age group of 5-16 years

Background: Fractures of the femur are the most incapacitating fractures. The best treatment for children between five to sixteen years of age is still debated. The ESIN has the benefits of early immediate stability to the involved bone segment, permitting early mobilization and return to the normal activities of the patients, respect for the physes, minimal scarring with lower complications. The purpose of this study was to present this study results following fixation of femoral shaft fractures with titanium elastic nails between the age 5-16 years of age.Methods: A total 52 patients in the age group of 5-16 years with femoral shaft fractures were stabilized using flexible nailing. Clinical and radiological follow-up was for a minimum period of 24 months. The final results were analysed using Flynn’s criteria.Results: Mean age at surgery was 7.4 years (range 5.6-14.3 years). The average duration of surgery was 65.3 (45-95) minutes and the mean duration of hospital stay was 8 (5-14) days. Skin irritation due to nail ends was the most common complication followed by significant lengthening (n=6), infection (n=2), significant shortening (n=2), varus angulation (n=2) and delayed union (n=2). The final outcome was excellent in 65.4% cases, satisfactory in 30.8% cases and three patients had poor outcomes as per Flynn's scoring criteria.Conclusions: In this study, ESIN showed good clinical and radiographic results in the age group 5 to 16 years, with minimal complications and high parent satisfaction consistent with previous studies but lesser number of mid adolescent age groups in the present study is a limitation

Synthesis and characterization of carbon nano​/microspheres from starch by low-​temperature hydrothermal procedure

A convenient method of synthesis of carbon nano​/microspheres by hydrothermal at very low temp. of 190 °C has been reported. The method uses starch, a polysaccharide material as carbon source in an acidic medium. The product obtained was subjected for characterization after washing and drying. X-​ray powder diffraction, Fourier transform IR and Raman spectroscopic studies reveal the graphitic nature of the products. The SEM and transmission electron microscopic images show the large no. of free spheres. Mostly they are microspheres with some nanospheres having a mean diam. of 100 nm-​1 μm. The surface area and pore vol. values as calcd. are 2.9559 m2/g and 0.006161 cm3/g resp. The spheres display a unimodal pore size distribution. The mechanism of the formation of carbon microspheres under hydrothermal conditions can be ascribed to direct dehydration polymn. and self- assembling fusion process. The scanning electron microscopic images depict a larger amt. of carbon microspheres nearly about 85-​95​% present in the product

Stability and Effective Process Control for Secure Email Filtering

A fantastic tool for both commercial and personal communication is electronic mail. It has increasingly become a necessary component of our working life since it is straightforward, available, and simple to use. Spam emails have started to tarnish internet experiences and threaten the integrity of email. Due to the exponential growth of spam, both people and organisations are under a great deal of financial and other strain. In order to prevent the future of email itself from being in jeopardy, a solution to the spam problem must be discovered. There is an urgent need to solve the Email spam issue since spam volume has been rising over the last several decades. As part of this effort, many effects of spam emails on businesses and people were noted and thoroughly examined. In order to properly assess current technologies, solutions, and methods, a comprehensive literature review was conducted throughout the procedures. The goals of this work is to develop new methodologies for the implementation of new strategies for the efficient management of email spam and to construct a proof-of-concept software system for the Process controlled assessment of such strategies

Performance Analysis of Maximal Ratio Combining with FBMC for 5G

One of the main objectives of upcoming 5G technology is to support huge data capacity with high data rate. To support high data traffic,designs of new multicarrier techniques are essential. FBMC is considered to be one such promising technique for 5G.The major concern with the wireless time varying channels when transmitting a signal is its nature and behavior for that period of duration. When mobile systems are used for transmission and reception across these time varying channels, the signals are subjected to ISI and multipath fading. These are the key setbacks which worsen the quality of overall received signal. The author proposes a solution to this problem by the use of receiver diversity techniques with Filter Bank Multi Carrier technique

Twin Pregnancy with a Complete Hydatidiform Mole and a Coexisting Live Fetus : Rare entity

A hydatidiform mole with a coexisting live fetus is a rare occurrence and the optimal management for this condition is not yet known. We report the case of a 32-year-old woman (gravida 3, para 2) who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in March 2012 at 13 gestational weeks with abdominal pain and vaginal bleeding. An ultrasound examination revealed a hydatidiform mole pregnancy coexisting with a live fetus. After extensive counselling, the patient and her husband opted for a conservative management approach. Unfortunately, a hysterotomy had to be performed at 17 gestational weeks due to severe haemorrhage. The postoperative period was uneventful and histopathology results confirmed one complete mole with a coexisting fetus and normal placenta. The patient’s serum β-human chorionic gonadotropin level remained normal for 18 months following her surgery

Pharmaceutical study & preliminary analysis of Sheetala Parpati

The Parpati kalpana is a thin flake form of mercurial preparation which is unique in the field of Rasashastra. It is one among the Chaturvidha Rasayana and Agnisthayi Murchita Parada Bandha i.e., Pota Bandha of Parada. Sheetala parpati is an Ayurvedic medicine that comes under Parpati kalpana, used in the treatment of difficulty in urination, urinary calculi, dyspepsia, etc. There are two different references of Sheetala Parpati where the ingredients and method of preparation are different. In the present work an attempt has been made to prepare both the varieties of Sheetala parpati along with its analytical study. It is mainly indicated in Mutrakricchra (Dysurea) and other diseases like Amlapitta (Hyperacidity), Udarashoola (Abdominal pain), Ajeerna (Indigestion), Yakritvikara (Hepatic disorder), etc. Keywords: Parpati kalpana, Chaturvidha Rasayana, Sheetala Parpati, Mutrakricchra (Dysurea

Orphan receptor GPR110, an oncogene overexpressed in lung and prostate cancer

<p>Abstract</p> <p>Background</p> <p>GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have important biological roles. In a retroviral insertion mutagenesis screen in the mouse, we identified GPR110 as an oncogene. This prompted us to study the potential isoforms that can be gleaned from known GPR110 transcripts, and the expression of these isoforms in normal and transformed human tissues.</p> <p>Methods</p> <p>Various epitope-tagged isoforms of GPR110 were expressed in cell lines and assayed by western blotting to determine cleavage, surface localization, and secretion patterns. GPR110 transcript and protein levels were measured in lung and prostate cancer cell lines and clinical samples, respectively, by quantitative PCR and immunohistochemistry.</p> <p>Results</p> <p>We found four potential splice variants of GPR110. Of these variants, we confirmed three as being expressed as proteins on the cell surface. Isoform 1 is the canonical form, with a molecular mass of about 100 kD. Isoforms 2 and 3 are truncated products of isoform 1, and are 25 and 23 kD, respectively. These truncated isoforms lack the seven-span transmembrane domain characteristic of GPR proteins and thus are not likely to be membrane anchored; indeed, isoform 2 can be secreted. Compared with the median gene expression of ~200 selected genes, GPR110 expression was low in most tissues. However, it had higher than average gene expression in normal kidney tissue and in prostate tissues originating from older donors. Although identified as an oncogene in murine T lymphomas, GPR110 is greatly overexpressed in human lung and prostate cancers. As detected by immunohistochemistry, GPR110 was overexpressed in 20 of 27 (74%) lung adenocarcinoma tissue cores and in 17 of 29 (59%) prostate adenocarcinoma tissue cores. Additionally, staining with a GPR110 antibody enabled us to differentiate between benign prostate hyperplasia and potential incipient malignancy.</p> <p>Conclusion</p> <p>Our work suggests a role for GPR110 in tumor physiology and supports it as a potential therapeutic candidate and disease marker for both lung and prostate cancer.</p

ATOMS : ALMA three-millimeter observations of massive star-forming regions - II. Compact objects in ACA observations and star formation scaling relations

We report studies of the relationships between the total bolometric luminosity (L-bol or L-TIR) and the molecular line luminosities of J = 1 - 0 transitions of (HCN)-C-13, (HCO+)-C-13, HCN, and HCO+ with data obtained from ACA observations in the 'ATOMS' survey of 146 active Galactic star-forming regions. The correlations between L-bol and molecular line luminosities L-mol' of the four transitions all appear to be approximately linear. Line emission of isotopologues shows as large scatters in L-bol-L-mol' relations as their main line emission. The log(L-bol/L-mol') for different molecular line tracers have similar distributions. The L-bol-to-L-mol' ratios do not change with galactocentric distances (R-GC) and clump masses (M-clump). The molecular line luminosity ratios (HCN-to-HCO+, (HCN)-C-13-to-(HCO+)-C-13, HCN-to-(HCN)-C-13, and HCO+-to-(HCO+)-C-13) all appear constant against L-bol, dust temperature (T-d), M-clump, and R-GC. Our studies suggest that both the main lines and isotopologue lines are good tracers of the total masses of dense gas in Galactic molecular clumps. The large optical depths of main lines do not affect the interpretation of the slopes in star formation relations. We find that the mean star formation efficiency (SFE) of massive Galactic clumps in the 'ATOMS' survey is reasonably consistent with other measures of the SFE for dense gas, even those using very different tracers or examining very different spatial scales.Peer reviewe

Functional Analysis of the Phycomyces carRA Gene Encoding the Enzymes Phytoene Synthase and Lycopene Cyclase

Phycomyces carRA gene encodes a protein with two domains. Domain R is characterized by red carR mutants that accumulate lycopene. Domain A is characterized by white carA mutants that do not accumulate significant amounts of carotenoids. The carRA-encoded protein was identified as the lycopene cyclase and phytoene synthase enzyme by sequence homology with other proteins. However, no direct data showing the function of this protein have been reported so far. Different Mucor circinelloides mutants altered at the phytoene synthase, the lycopene cyclase or both activities were transformed with the Phycomyces carRA gene. Fully transcribed carRA mRNA molecules were detected by Northern assays in the transformants and the correct processing of the carRA messenger was verified by RT-PCR. These results showed that Phycomyces carRA gene was correctly expressed in Mucor. Carotenoids analysis in these transformants showed the presence of ß-carotene, absent in the untransformed strains, providing functional evidence that the Phycomyces carRA gene complements the M. circinelloides mutations. Co-transformation of the carRA cDNA in E. coli with different combinations of the carotenoid structural genes from Erwinia uredovora was also performed. Newly formed carotenoids were accumulated showing that the Phycomyces CarRA protein does contain lycopene cyclase and phytoene synthase activities. The heterologous expression of the carRA gene and the functional complementation of the mentioned activities are not very efficient in E. coli. However, the simultaneous presence of both carRA and carB gene products from Phycomyces increases the efficiency of these enzymes, presumably due to an interaction mechanism