Frustrated magnets in three dimensions: a nonperturbative approach

Frustrated magnets exhibit unusual critical behaviors: they display scaling laws accompanied by nonuniversal critical exponents. This suggests that these systems generically undergo very weak first order phase transitions. Moreover, the different perturbative approaches used to investigate them are in conflict and fail to correctly reproduce their behavior. Using a nonperturbative approach we explain the mismatch between the different perturbative approaches and account for the nonuniversal scaling observed.Comment: 7 pages, 1 figure. IOP style files included. To appear in Journal of Physics: Condensed Matter. Proceedings of the conference HFM 2003, Grenoble, Franc

Pores in Bilayer Membranes of Amphiphilic Molecules: Coarse-Grained Molecular Dynamics Simulations Compared with Simple Mesoscopic Models

We investigate pores in fluid membranes by molecular dynamics simulations of an amphiphile-solvent mixture, using a molecular coarse-grained model. The amphiphilic membranes self-assemble into a lamellar stack of amphiphilic bilayers separated by solvent layers. We focus on the particular case of tension less membranes, in which pores spontaneously appear because of thermal fluctuations. Their spatial distribution is similar to that of a random set of repulsive hard discs. The size and shape distribution of individual pores can be described satisfactorily by a simple mesoscopic model, which accounts only for a pore independent core energy and a line tension penalty at the pore edges. In particular, the pores are not circular: their shapes are fractal and have the same characteristics as those of two dimensional ring polymers. Finally, we study the size-fluctuation dynamics of the pores, and compare the time evolution of their contour length to a random walk in a linear potential

The critical behavior of frustrated spin models with noncollinear order

We study the critical behavior of frustrated spin models with noncollinear order, including stacked triangular antiferromagnets and helimagnets. For this purpose we compute the field-theoretic expansions at fixed dimension to six loops and determine their large-order behavior. For the physically relevant cases of two and three components, we show the existence of a new stable fixed point that corresponds to the conjectured chiral universality class. This contradicts previous three-loop field-theoretical results but is in agreement with experiments.Comment: 4 pages, RevTe

Monte Carlo renormalization group study of the Heisenberg and XY antiferromagnet on the stacked triangular lattice and the chiral ϕ4\phi^4 model

With the help of the improved Monte Carlo renormalization-group scheme, we numerically investigate the renormalization group flow of the antiferromagnetic Heisenberg and XY spin model on the stacked triangular lattice (STA-model) and its effective Hamiltonian, 2N-component chiral $\phi^4$ model which is used in the field-theoretical studies. We find that the XY-STA model with the lattice size $126\times 144 \times 126$ exhibits clear first-order behavior. We also find that the renormalization-group flow of STA model is well reproduced by the chiral $\phi^4$ model, and that there are no chiral fixed point of renormalization-group flow for N=2 and 3 cases. This result indicates that the Heisenberg-STA model also undergoes first-order transition.Comment: v1:15 pages, 15 figures v2:updated references v3:added comments on the higher order irrelevant scaling variables v4:added results of larger sizes v5:final version to appear in J.Phys.Soc.Jpn Vol.72, No.

Testing for Features in the Primordial Power Spectrum

Well-known causality arguments show that events occurring during or at the end of inflation, associated with reheating or preheating, could contribute a blue component to the spectrum of primordial curvature perturbations, with the dependence k^3. We explore the possibility that they could be observably large in CMB, LSS, and Lyman-alpha data. We find that a k^3 component with a cutoff at some maximum k can modestly improve the fits (Delta chi^2=2.0, 5.4) of the low multipoles (l ~ 10 - 50) or the second peak (l ~ 540) of the CMB angular spectrum when the three-year WMAP data are used. Moreover, the results from WMAP are consistent with the CBI, ACBAR, 2dFGRS, and SDSS data when they are included in the analysis. Including the SDSS galaxy clustering power spectrum, we find weak positive evidence for the k^3 component at the level of Delta chi' = 2.4, with the caveat that the nonlinear evolution of the power spectrum may not be properly treated in the presence of the k^3 distortion. To investigate the high-k regime, we use the Lyman-alpha forest data (LUQAS, Croft et al., and SDSS Lyman-alpha); here we find evidence at the level Delta chi^2' = 3.8. Considering that there are two additional free parameters in the model, the above results do not give a strong evidence for features; however, they show that surprisingly large bumps are not ruled out. We give constraints on the ratio between the k^3 component and the nearly scale-invariant component, r_3 < 1.5, over the range of wave numbers 0.0023/Mpc < k < 8.2/Mpc. We also discuss theoretical models which could lead to the k^3 effect, including ordinary hybrid inflation and double D-term inflation models. We show that the well-motivated k^3 component is also a good representative of the generic spikelike feature in the primordial perturbation power spectrum.Comment: 23 pages, 6 figures; added new section on theoretical motivation for k^3 term, and discussion of double D-term hybrid inflation models; title changed, added a new section discussing the generic spikelike features, published in IJMP

Natural Product Celastrol Destabilizes Tubulin Heterodimer and Facilitates Mitotic Cell Death Triggered by Microtubule-Targeting Anti-Cancer Drugs

Microtubule drugs are effective anti-cancer agents, primarily due to their ability to induce mitotic arrest and subsequent cell death. However, some cancer cells are intrinsically resistant or acquire a resistance. Lack of apoptosis following mitotic arrest is thought to contribute to drug resistance that limits the efficacy of the microtubule-targeting anti-cancer drugs. Genetic or pharmacological agents that selectively facilitate the apoptosis of mitotic arrested cells present opportunities to strengthen the therapeutic efficacy.. At the cellular level, Celastrol induces a synergistic apoptosis when combined with conventional microtubule-targeting drugs and manifests an efficacy toward Taxol-resistant cancer cells. Finally, by time-lapse imaging and tracking of microtubule drug-treated cells, we show that Celastrol preferentially induces apoptosis of mitotic arrested cells in a caspase-dependent manner. This selective effect is not due to inhibition of general cell survival pathways or mitotic kinases that have been shown to enhance microtubule drug-induced cell death.We provide evidence for new cellular pathways that, when perturbed, selectively induce the apoptosis of mitotic arrested cancer cells, identifying a potential new strategy to enhance the therapeutic efficacy of conventional microtubule-targeting anti-cancer drugs

Réduction des réflexions parasites produites par des panneaux à modulation périodique d'impédance de surface

International audienceCette communication propose une nouvelle méthodologie pour mieux contrôler le rayonnement de panneaux plans réfléchissants à modulation périodique d'impédance de surface. Il s'agit en particulier de limiter les réflexions parasites associées aux harmoniques de Floquet d'ordre supérieur. L'approche s'appuie sur la définition de paramètres permettant d'évaluer a priori le potentiel des motifs périodiques candidats et est validée par des simulations électromagnétiques

Flat Energy-Histogram Simulation of the Phase Transition in an Ising Fully Frustrated Lattice

We show in this paper the results on the phase transition of the so-called fully frustrated simple cubic lattice with the Ising spin model. We use here the Monte Carlo method with the flat energy-histogram Wang-Landau technique which is very powerful to detect weak first-order phase transition. We show that the phase transition is clearly of first order, providing a definite answer to a question raised 25 years ago.Comment: Submitted for publicatio

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

The tumor suppressor gene HIC1 (Hypermethylated In Cancer 1) encodes a transcriptional repressor mediating the p53-dependent apoptotic response to irreparable DNA double-strand breaks (DSBs) through direct transcriptional repression of SIRT1. HIC1 is also essential for DSB repair as silencing of endogenous HIC1 in BJ-hTERT fibroblasts significantly delays DNA repair in functional Comet assays. HIC1 SUMOylation favours its interaction with MTA1, a component of NuRD complexes. In contrast with irreparable DSBs induced by 16-hours of etoposide treatment, we show that repairable DSBs induced by 1 h etoposide treatment do not increase HIC1 SUMOylation or its interaction with MTA1. Furthermore, HIC1 SUMOylation is dispensable for DNA repair since the non-SUMOylatable E316A mutant is as efficient as wt HIC1 in Comet assays. Upon induction of irreparable DSBs, the ATM-mediated increase of HIC1 SUMOylation is independent of its effector kinase Chk2. Moreover, irreparable DSBs strongly increase both the interaction of HIC1 with MTA1 and MTA3 and their binding to the SIRT1 promoter. To characterize the molecular mechanisms sustained by this increased repression potential, we established global expression profiles of BJ-hTERT fibroblasts transfected with HIC1-siRNA or control siRNA and treated or not with etoposide. We identified 475 genes potentially repressed by HIC1 with cell death and cell cycle as the main cellular functions identified by pathway analysis. Among them, CXCL12, EPHA4, TGFβR3 and TRIB2, also known as MTA1 target-genes, were validated by qRT-PCR analyses. Thus, our data demonstrate that HIC1 SUMOylation is important for the transcriptional response to non-repairable DSBs but dispensable for DNA repair

Interacting particles at a metal-insulator transition

We study the influence of many-particle interaction in a system which, in the single particle case, exhibits a metal-insulator transition induced by a finite amount of onsite pontential fluctuations. Thereby, we consider the problem of interacting particles in the one-dimensional quasiperiodic Aubry-Andre chain. We employ the density-matrix renormalization scheme to investigate the finite particle density situation. In the case of incommensurate densities, the expected transition from the single-particle analysis is reproduced. Generally speaking, interaction does not alter the incommensurate transition. For commensurate densities, we map out the entire phase diagram and find that the transition into a metallic state occurs for attractive interactions and infinite small fluctuations -- in contrast to the case of incommensurate densities. Our results for commensurate densities also show agreement with a recent analytic renormalization group approach.Comment: 8 pages, 8 figures The original paper was splitted and rewritten. This is the published version of the DMRG part of the original pape