Pengembangan Media Pembelajaran Kimia Berbasis Powtoon pada Pokok Bahasan Hidrokarbon di Kelas XI Sma/sederajat

This study is aimed to develop learning media by using PowToon on the subject of Hydrocarbon at SMA/MA. The result of this study is a product of learning media in the form of CD (compact disk) for Hydrocarbon subject which has contents as follows: the characteristic of carbon, alcana,alchene and alcuna, the application carbon in daily. This study used Research and Development (R&D) method with ADDIE model which has five stages of development; they are analysis, design, development, implementation, and evaluation. The development model was modified by the writer only until the development stage. The result of validation test showed that learning media on the subject of Hydrocarbon is valid with the result of validation by media experts and material experts 89,63%, so the developed learning media is properly used on the learning and teaching process. The result of the development has been limited test on 22 students and then 2 chemistry teacher in senior high school average score percentase obtained by 89,63

Gambaran Pengunaan Pil Kb Pada Wanita Usia Subur Dengan Hipertensi Diwilayah Kerja Puskesmas Tanawangko Kecamatan Tombariri

Kawulur, Liani. Gambaran Penggunaan Pil Kb Pada Wanita Usia Subur Di Wilayah Kerja Puskesmas Tanawangko Kecamatan Tombariri. Skripsi. Fakultas Kedokteran. Program Studi Ilmu Keperawatan. Universitas Sam Ratulangi. Pembimbing: (I) Rina M. Kundre (II) Franly OnibalThe Purposes: To overview the use of birth control pills in women of childbearing age in the sub-district Puskesmas Tanawangko Tombariri. Samples were taken there 45 respondents. Methods This study used observational survey design with cross sectional approach. Results of this study found picture Pill users with a woman of fertile age in Puskesmas Tanawangko. Recommendation: For health services, disseminate to women of childbearing age who followed the family planning program about the advantages and disadvantages of each type of family planning programs as well as side effects.Keywords: WUS, Birth Control PilKawulur, Liani. Gambaran Penggunaan Pil Kb Pada Wanita Usia Subur Di Wilayah Kerja Puskesmas Tanawangko Kecamatan Tombariri. Skripsi. Fakultas Kedokteran. Program Studi Ilmu Keperawatan. Universitas Sam Ratulangi. Pembimbing: (I) Rina M. Kundre (II)Franly OnibalaTujuan: Mengetahui gambaran penggunaan pil KB pada wanita usia subur di wilayah kerja Puskesmas Tanawangko Kecamatan Tombariri. Sampel yang diambil ada 45 responden. Metode Penelitian ini menggunakan desain Survey Observasional dengan Pendekatan Cross Sectional. Hasil penelitian ini didapatkan gambaran pengguna pil KB dengan Wanita Usia Subur di Puskesmas Tanawangko. Saran: Bagi tempat pelayanan kesehatan, mensosialisasikan kepada wanita usia subur yang mengikuti program KB tentang keuntungan dan kekurangan setiap jenis program KB serta efek sampingnya

Generation of TWO G51D SNCA missense mutation iPSC lines (CRICKi011-A, CRICKi012-A) from two individuals at risk of Parkinson's disease

Mutations or multiplications of the SNCA (Synuclein Alpha) gene cause rare autosomal dominant Parkinson's disease (PD). The SNCA G51D missense mutation is associated with a synucleinopathy that shares PD and multiple system atrophy (MSA) characteristics. We generated induced pluripotent stem cell (iPSC) lines from two individuals with SNCA G51D missense mutations at risk of PD. Dermal fibroblasts were reprogrammed to pluripotency using a non-integrating mRNA-based protocol. The resulting human iPSCs displayed normal morphology, expressed markers associated with pluripotency, and differentiated into the three germ layers. The iPSC lines could facilitate disease-modelling and therapy development studies for synucleinopathies

Uneven ground? Intersectional gender inequalities in the commercialized cassava seed system in Tanzania

Open Access JournalCassava (Manihot esculenta Crantz) is an important crop in Africa, especially to women who rely on it as a household staple food and source of income. In Tanzania, a recent move toward commercializing the cassava seed system resulted in significantly fewer women than men farmers, known as Cassava Seed Entrepreneurs (CSEs), producing improved seed for sale to fellow farmers. To document the barriers and constraints that create gender inequalities in the seed system to better understand women’s low representation and experiences in commercialized cassava seed production, we carried out a mixed-methods study in the Southern, Eastern, and Lake Zones of Tanzania in 2021. The quantitative analysis found differences in key individual and household characteristics between CSEs and farmers who aspired to be but did not participate as CSEs (or A-CSEs) as well as between women CSEs and women A-CSEs. After running a logistic regression, results indicated that sex of the farmer (being male) was a statistically significant predictor of participating as a CSE (p < 0.05), along with having a secondary education (p < 0.05) and owning a bank account (p < 0.01). The qualitative analysis highlighted challenges women CSEs face. They spoke about having lower access to and control over prerequisite resources, which are shaped by other intersecting social identities such as marital status and age. Gender stereotypes about their capacities to manage their seed businesses can demotivate them from carrying out their work as well as experiences dealing with discriminatory gender norms that limit their travel to attend trainings outside their communities. Despite these barriers, some women CSEs expressed positive outcomes that have accrued from their participation in commercialized seed production, including enhanced social status and improved living standards. For the commercialized cassava seed system to be more socially inclusive and sustainable, we argue that there is need to adopt gender-aware approaches to address the underlying barriers and biases that exclude women and other social groups. Development efforts should consider combining social change innovations with seed system interventions to address the inequitable norms and power relations that create unique constraints for women to operate effectively as seed entrepreneurs

The ubiquitin proteasome system in neuropathology

The ubiquitin proteasome system (UPS) orchestrates the turnover of innumerable cellular proteins. In the process of ubiquitination the small protein ubiquitin is attached to a target protein by a peptide bond. The ubiquitinated target protein is subsequently shuttled to a protease complex known as the 26S proteasome and subjected to degradative proteolysis. The UPS facilitates the turnover of proteins in several settings. It targets oxidized, mutant or misfolded proteins for general proteolytic destruction, and allows for the tightly controlled and specific destruction of proteins involved in development and differentiation, cell cycle progression, circadian rhythms, apoptosis, and other biological processes. In neuropathology, alteration of the UPS, or mutations in UPS target proteins may result in signaling abnormalities leading to the initiation or progression of tumors such as astrocytomas, hemangioblastomas, craniopharyngiomas, pituitary adenomas, and medulloblastomas. Dysregulation of the UPS may also contribute to tumor progression by perturbation of DNA replication and mitotic control mechanisms, leading to genomic instability. In neurodegenerative diseases caused by the expression of mutant proteins, the cellular accumulation of these proteins may overload the UPS, indirectly contributing to the disease process, e.g., sporadic Parkinsonism and prion diseases. In other cases, mutation of UPS components may directly cause pathological accumulation of proteins, e.g., autosomal recessive Parkinsonism and spinocerebellar ataxias. Defects or dysfunction of the UPS may also underlie cognitive disorders such as Angelman syndrome, Rett syndrome and autism, and muscle and nerve diseases, e.g., inclusion body myopathy and giant axon neuropathy. This paper describes the basic biochemical mechanisms comprising the UPS and reviews both its theoretical and proven involvement in neuropathological diseases. The potential for the UPS as a target of pharmacological therapy is also discussed