Pengaruh Konsentrasi Xanthan Gum Terhadap Stabilitas Fisik Krim Virgin Coconut Oil (Vco)

Virgin Coconut Oil (VCO) is a pure oils that is extracted from fresh coconut meat at low temperatures. The formulation of VCO in cream dosage form could retain skin moisture and improve the acceptability. Xanthan gum is one of the emulsifier that used to form oil in water (O/W) cream. The purpose of this research were to determine the effect of xanthan gum concentration to the physical stability of VCO cream. VCO creams were prepared by emulsifying the oil phase and the water phase with the variation of xanthan gum concentration (2.5; 2.7; 2.9; 3.1; 3.3% w/w). Observation of the physical stability of the cream includes organoleptic, emulsion type, droplets size, viscosity, spreadability, adhesion, and ratio of separation volume was conducted until 7th week, and also the freeze-thaw test for three cycles. The results showed that each formulation could produces homogeneous light brown cream with oil in water type. Increasing of xanthan gum concentration would increases viscosity of the cream so that spreadability decreases and adhesion increases during stability study. Ratio of separation volume increased after three cycles of freeze-thaw test. Cream with 3.3% w/w xanthan gum had the optimum physical stability

Pengaruh Konsentrasi Xanthan Gum Terhadap Stabilitas Fisik Krim Virgin Coconut Oil (Vco)

Virgin Coconut Oil (VCO) is a pure oils that is extracted from fresh coconut meat at low temperatures. The formulation of VCO in cream dosage form could retain skin moisture and improve the acceptability. Xanthan gum is one of the emulsifier that used to form oil in water (O/W) cream. The purpose of this research were to determine the effect of xanthan gum concentration to the physical stability of VCO cream. VCO creams were prepared by emulsifying the oil phase and the water phase with the variation of xanthan gum concentration (2.5; 2.7; 2.9; 3.1; 3.3% w/w). Observation of the physical stability of the cream includes organoleptic, emulsion type, droplets size, viscosity, spreadability, adhesion, and ratio of separation volume was conducted until 7th week, and also the freeze-thaw test for three cycles. The results showed that each formulation could produces homogeneous light brown cream with oil in water type. Increasing of xanthan gum concentration would increases viscosity of the cream so that spreadability decreases and adhesion increases during stability study. Ratio of separation volume increased after three cycles of freeze-thaw test. Cream with 3.3% w/w xanthan gum had the optimum physical stability

Formulation effects in percutaneous absorption

Formulation optimisation is one of the strategies used for optimising delivery into or through the skin. In addition to ensuring that an active chemical is delivered at an adequate rate to achieve therapeutic concentrations over the intended duration, physicochemical formulation stability as well as product acceptance must also be achieved. There is a continual growth in new potential delivery systems, such as microemulsions, liposomes, ultradeformable liposomes and lipid nanoparticles, offering various advantages, either for dermal and transdermal delivery. However, choosing and designing the most suitable formulation system for a given compound is a complex process. In this chapter, various aspects of formulation-related transdermal drug delivery are discussed and an alternative approach to the design of formulation systems is reviewed. In addition, current formulation-based strategies and the effects of commonly added ingredients for stability and aesthetic purposes are covered. Finally, formulations based on some novel delivery systems are discussed