Civil War Congress and the Creation of Modern America: A Revolution on the Home Front

Most literature on the Civil War focuses on soldiers, battles, and politics. But for every soldier in the United States Army, there were nine civilians at home. The war affected those left on the home front in many ways. Westward expansion and land ownership increased. The draft disrupted families while a shortage of male workers created opportunities for women that were previously unknown. The war also enlarged the national government in ways unimagined before 1861. The Homestead Act, the Land Grant College Act, civil rights legislation, the use of paper currency, and creation of the Internal Revenue Service to collect taxes to pay for the war all illustrate how the war fundamentally, and permanently, changed the nation. The essays in this book, drawn from a wide range of historical expertise and approaching the topic from a variety of angles, explore the changes in life at home that led to a revolution in American society and set the stage for the making of modern America. Contributors: Jean H. Baker, Jenny Bourne, Paul Finkelman, Guy Gugliotta, Daniel W. Stowell, Peter Wallenstein, Jennifer L. Weber.https://ohioopen.library.ohio.edu/oupress/1019/thumbnail.jp

Telomerase Inhibition and Sensitization of Breast Tumor Cells

Telomerase, a ribonucleoprotein enzyme minimally composed of an RNA template (hTR) and a catalytically active protein subunit (hTERT), synthesizes telomeric repeats onto chromosome ends and is obligatory for continuous tumor cell proliferation, as well as malignant progression of breast cancer cells. Telomerase is an attractive anticancer therapeutic target because its activity is present in over 90% of human cancers, including more than 95% of breast carcinomas, but undetectable in most somatic cells. Traditions chemo- and radio-therapies lack the ability to effectively control and cure breast cancer, in part because residual cells are or become resistant to DNA damaging modalities.While various telomerase inhibition strategies cause cancer cells to undergo apoptosis car senescence, there is often a lag period between administration and biologic effect (Corey, 2002). Our goal in this study was to compare the efficacy of different telomerase inhibition strategies in concert with standard chemotherapeutic agents at triggering senescence and/or apoptosis in cultures of breast cancer cells. We hypothesized that telomerase inhibition strategies will sensitize breast cancer cells to traditional chemotherapies, potentially reducing the lag phase, allowing for more potent anti-tumor effects at lower doses, and therefore ultimately imparting less toxicity to the patient.We blocked telomerase by targeting hTR and hTERT, individually and collectively utilizing synthetic short interfering RNA (siRNA), short hairpin RNA (siRNA), and a dominant negative form of hTERT (DN-hTERT) in MCF-7 breast cancer cells. We analyzed the efficiency of telomerase inhibition for each strategy alone and then treated the cells with two mainstay chemotherapeutic agents, Adriamycin (AdR) and Taxol. The most effective telomerase inhibition strategies were synthetic siRNA and DN-hTERT, individually. After treatment with various concentrations of AdR or Taxol, breast cancer cells with inhibited telomerase grew significantly slower and exhibited widespread senescence or apoptosis within a much shorter time period and at a dose that is insufficient to trigger cytostasis. In addition, we provide evidence that cells in which telomerase was inhibited were more sensitive to anti-cancer agents, whether the drug inhibited topoisomerase II resulting in DNA damage (AdR) or blocked mitosis via protracted microtubule stabilization (Taxol). Collectively, our data indicate that alone, anti-telomerase inhibition strategies differ in their efficacy. However, when used in the adjuvant setting with diverse acting chemotherapeutic agents, there is a potent synergy resulting in chemotherapeutic sensitization characterized in part by widespread senescence and/or apoptosis

PANEL SURVEY ESTIMATION IN THE PRESENCE OF LATE REPORTING AND NONRESPONSE

Estimates from economic panel surveys are generally required to be published soon after the survey reference period, resulting in missing data due to late reporting as well as nonresponse. Estimators currently in use make some attempt to correct for the impact of missing data. However, these approaches tend to simplify the assumed nature of the missing data and often ignore a portion of the reported data for the reference period. Discrepancies between preliminary and revised estimates highlight the inability of the estimation methodology to correct for all error due to late reporting. The current model for one economic panel survey, the Current Employment Statistics survey, is examined to identify factors related to potential model misspecification error, leading to identification of an extended model. An approach is developed to utilize all reported data from the current and prior reference periods, through missing data imputation. Two alternatives to the current models that assume growth rates are related to recent reported data and reporting patterns are developed, one a simple proportional model, the other a hierarchical fixed effects model. Estimation under the models is carried out and performance compared to that of the current estimator through use of historical data from the survey. Results, although not statistically significant, suggest the potential associated with use of reported data from recent time periods in the working model, especially for smaller establishments. A logistic model for predicting likelihood of late reporting for sample units that did not report for preliminary estimates is also developed. The model uses a combination of operational, respondent, and environmental factors identified from a reporting pattern profile. Predicted conditional late reporting rates obtained under the model are compared to actual rates through use of historical information for the survey. Results indicate the appropriateness of the parameters chosen and general ability of the model to predict final reporting status. Such a model has the potential to provide information to survey managers for addressing late reporting and nonresponse

Spherical Panoramic Image Payload Design for Stratospheric Ballooning

The 2017 total solar eclipse inspired innovation in design and implementation in stratospheric ballooning techniques and payloads to fully document the unique near-space experience. The Arkansas BalloonSAT team, as part of the Eclipse Ballooning Project, designed and fabricated a spherical panoramic image payload using computer aided design (CAD) software to capture images of the eclipse from the high altitude balloon. The light, durable, and water resistant mount consisted of a polyurethane-coated UV-resin based enclosure that housed six Hero 4 Session GoPro cameras, and a relative inertial measurement unit (IMU) PCB equipped with GPS. The cameras’ lenses faced radially outward on the six faces of a cube. The IMU/GPS PCB system computed the absolute orientation of the cameras, which allows the time-lapse pictures to be stitched together into a relatively stable spherical video. The batteries for this system experienced a voltage drop during flight as the payload temperature dropped below -60 degrees Celsius resulting in an auto-shutdown procedure disabling the system before eclipse totality. Future designs for this model will include a temperature regulation or insulation system to prevent this voltage drop

Observing the 2017 Total Solar Eclipse in the skies above Central Missouri, USA

We report the work and findings of Arkansas BalloonSAT in participating in the 2017 Eclipse Ballooning Project. Arkansas BalloonSAT was the site-team for Missouri and launched a high altitude balloon from Fulton High School in Fulton, MO an hour prior to totality. This balloon reached an apogee of 24 kilometers shortly after floating for one minute in the moon\u27s umbra. In addition to live-streaming video from one payload as part of the Eclipse Ballooning Project, our mission included carrying a scientific payload and educational outreach. This report will summarize those efforts and include an examination of balloon kinematics with the cooling effect of the moon\u27s umbra and aircraft-balloon interaction. We further discuss developments in the system to minimize payload size for future eclipse studies

Case reports describing treatments in the emergency medicine literature: missing and misleading information

Abstract Background Although randomized trials and systematic reviews provide the "best evidence" for guiding medical practice, many emergency medicine journals still publish case reports (CRs). The quality of the reporting in these publications has not been assessed. Objectives In this study we sought to determine the proportion of treatment-related case reports that adequately reported information about the patient, disease, interventions, co-interventions, outcomes and other critical information. Methods We identified CRs published in 4 emergency medicine journals in 2000–2005 and categorized them according to their purpose (disease description, overdose or adverse drug reactioin, diagnostic test or treatment effect). Treatment-related CRs were reviewed for the presence or absence of 11 reporting elements. Results All told, 1,316 CRs were identified; of these, 85 (6.5%; 95CI = 66, 84) were about medical or surgical treatments. Most contained adequate descriptions of the patient (99%; 95CI = 95, 100), the stage and severity of the patient's disease (88%; 95CI = 79, 93), the intervention (80%; 95CI = 70, 87) and the outcomes of treatment (90%; 95CI = 82, 95). Fewer CRs reported the patient's co-morbidities (45%; 95CI = 35, 56), concurrent medications (30%; 95CI = 21, 40) or co-interventions (57%; 95CI = 46, 67) or mentioned any possible treatment side-effects (33%; 95CI = 24, 44). Only 37% (95CI = 19, 38) discussed alternative explanations for favorable outcomes. Generalizability of treatment effects to other patients was mentioned in only 29% (95CI = 20, 39). Just 2 CRs (2.3%; 95CI = 1, 8) reported a 'denominator" (number of patients subjected to the same intervention, whether or not successful. Conclusion Treatment-related CRs in emergency medicine journals often omit critical details about treatments, co-interventions, outcomes, generalizability, causality and denominators. As a result, the information may be misleading to providers, and the clinical applications may be detrimental to patient care.</p