The place of Bhakti in Vedant traditioin - with reference to Shri Vallabha Darshan

Not availabl

A comparative study of effectiveness, safety and cost effectiveness of olanzapine, risperidone and aripiprazole therapy in schizophrenia

Background: Schizophrenia is the most common psychotic disorder and responsible for approximately half of long-term psychiatric hospitalizations. Antipsychotic medications reduce the psychotic symptoms and prevent relapses. The choice of drug for treatment of schizophrenia depends on many issues, including effectiveness, cost, side-effect burden, availability, and tolerability. Many studies have compared antipsychotic drugs with one another, but no broad consensus has been reached. Our study compares the clinical effectiveness, safety and cost effectiveness of atypical antipsychotics in our setting.Methods: This was an observational, prospective study in which schizophrenia patients receiving either olanzapine, risperidone or aripiprazole were enrolled. Patients were followed up for 3 months. Evaluation of effectiveness was done by analysing mean reduction in PANSS score. Analysis of ADRs was done using WHO causality scale and Hartwig and Siegel severity scale. Cost analysis was done by comparing all three groups in term of cost range of antipsychotic drugs per improvement in PANSS score during the study period.Results: In the present study, the average dose of antipsychotic drugs received by a patient per day was 8.83±2.98 mg in olanzapine group, 4.76±1.12 mg in risperidone group and 20.43±8.5 mg in aripiprazole group. Mean reduction in PANSS score from baseline to 12 weeks was 23.79% in olanzapine group, 25.41% in risperidone group and 24.65% in aripiprazole group. Conclusions: All the groups were equally effective in reduction in PANSS score while risperidone was the most cost effective

Systematic Review of Molecular Biomarkers Predictive of Resistance to CDK4/6 Inhibition in Metastatic Breast Cancer

Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors have revolutionized the treatment of hormone-positive metastatic breast cancers (mBCs). They are currently established as standard therapies in combination with endocrine therapy as first- and second-line systemic treatment options for both endocrine-sensitive and endocrine-resistant mBC populations. In the first-line metastatic setting, the median progression-free survival for the three currently approved CDK4/6 inhibitors, palbociclib, ribociclib, and abemaciclib, with aromatase inhibitors is greater than 2 years (palbociclib 27.6 months; ribociclib 25.3 months; and abemaciclib 28.18 months). Although CDK4/6 inhibitors have significant clinical benefits and enable physicians to delay starting chemotherapy, they are expensive and can be associated with drug toxicities. Here, we have performed a systemic review of the reported molecular markers predictive of drug response including intrinsic and acquired resistance for CDK4/6 inhibition in mBC. The rapidly emerging molecular landscape is captured through next-generation sequencing of breast cancers (DNA with or without RNA), liquid biopsies (circulating tumor DNA), and protein analyses. Individual molecular candidates with robust and reliable evidence are discussed in more depth

Pembuatan Lem Lateks dari Limbah Styrofoam yang Digunakan untuk Kemasan Makanan

Styrofoam merupakan suatu polistirena yang sudah dipadatkan dan dibentuk sesuai dengan kebutuhan. Styrofoam banyak digunakan untuk pengemasan barang-barang elektronik dan sebagai kemasan makanan. Beberapa hal pada styrofoam yang sangat menguntungkan bagi para penjual makanan dan penjual alat elekrtonik adalah tidak mudah bocor, praktis, ringan dan ekonomis. Disisi lain setelah styrofoam tidak digunakan, akan menjadi limbah yang sulit untuk diuraikan. Bahkan pada proses produksinya sendiri menghasilkan limbah yang banyak sehingga dikategorikan sebagai penghasil limbah berbahaya ke-5 terbesar di dunia oleh EPA (Enviromental Protection Agency). Pada penelitian ini dilakukan upaya mengurangi limbah styrofoam dengan merubahnya menjadi Lem Lateks. Metode penelitianya adalah mencampurkan 30 gram limbah Styrofoam dengan 70 ml Toluen. Lem Lateks pekat yang terbentuk bersifat tidak stabil atau cepat mengalami penggumpalan. Agar lateks tersebut tidak menggumpal maka dilakukan proses emulsi dengan menambahkan emulsifier ABS (Alkil Benzena Sulfonat) yang merupakan senyawa aktif. Hasil yang baik dieroleh pada campuran 90 ml larutan polistirena dengan 10 ml aquades dan dengan penambahan 5% Alkil Benzena Sulfonat (ABS) pada waktu penyimpanan selama 3 hari

FLOOD SUSCEPTIBILITY MODELLING USING GEOSPATIAL-BASED MULTI-CRITERIA DECISION MAKING IN LARGE SCALE AREAS

Flood is one of the most hazardous natural disasters that cause damages and poses a major threat to human lives and infrastructures worldwide, and its prevention is almost unfeasible. Thus, the detection of flood susceptible areas can be a key to lessen the amount of destruction and mortality. This study aims to implement a framework to identify flood potential zones in an ungauged large-scale area with frequent flood events in recent years. We used two Multi-Criteria Decision Making (MCDM) approaches combined with geospatial analysis, and remote sensing observations for this susceptibility analysis. Nine geomorphological and environmental factors that have an impact on flood behaviour were selected and used for susceptibility modelling. At first, the criteria’s weights were estimated using two MCDM approaches and based on experts’ knowledge. The resultant weights revealed that Flow Accumulation, Topographic wetness index, and Distance to River were the most influential flood susceptibility criteria. After calculating these weights, the criteria’s layers were aggregated through geospatial analysis, which resulted in generating flood susceptibility map. The area under the curve (AUC) and statistical measures such as the Kappa index were used to evaluate the proposed method's efficiency. The validation results illustrate that hybrid FAHP, with AUC= 96.68 and Kappa = 81.36 performed more efficiently than standard AHP, with AUC= 94.53 and Kappa=76.35. Overlaying these maps with the historical flood inventory dataset revealed that 86.43% of flooded areas were categorized as “high” and “very high”. Therefore, the flood susceptibility maps generated through the proposed approach can help the decision-makers and managers allocate the mitigation equipment and facility in data-scarce and ungauged large-scale areas

A critical evaluation of promotional drug literatures available with prescribers at a tertiary care teaching hospital in Gujarat, India

Background: Promotional literature provided by the pharmaceutical companies is one of the important marketing strategies to prescribe. Many of these literatures do not follow ethical guidelines and contain biased and irrelevant information that may cause irrational prescribing. So we did this study with an aim to check the credibility, reliability and authenticity of the PDLs available with prescribers.Methods: Promotional drug literatures were analyzed based on various parameters and guidelines provided by world health organization. Statistical analysis was done using Microsoft Excel.Results: A total 395 promotional drug literatures were analyzed and very few of them fulfilled the ethical criteria for drug promotion. Most of them focused on providing information about generic name, brand name manufacture company name and claims about efficacy. Few of them focused on safety of drugs as less information provided about adverse reaction, precaution and drug-drug interaction. Many of them contain space occupying unnecessary pictures.Conclusions: It can be concluded that the majority of the promotional advertisements that were given to the prescribers do not follow ethical guidelines and were not able to improve rational prescribing but only have commercial benefits

Comparative study of clinical and endocrinal profile between lean and obese patients of polycystic ovary syndrome

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder having escalation in its prevalence. It is the most frequent cause of oligoanovulatory infertility. This study was conducted to compare the clinical and endocrinal profile of PCOS in lean PCOS (BMI<23 kg/m2) and obese PCOS (BMI>23 kg/m2) women. Methods: A prospective study was conducted for 6 months in department of obstetrics and gynecology, GMERS Medical college, Junagadh. 100 healthy women who were euthyroid with age range 20-38 years who presented to gynecology OPD and diagnosed to have PCOS according to ESHRE/ASRM criteria were included in the study. BMI (body mass index) was calculated by the formula weight in kg/height in meter square. BMI were calculated were divided into 2 groups. Lean PCOS found in patients with BMI<23 kg/m2 and overweight/obese PCOS found in patients with BMI>23 kg/m2. History of menstrual irregularity, hirsutism, acne, alopecia, infertility, history of weight gain, history of voice change, family history of PCOS, diabetes was taken and hormonal profile was done. Results: The findings showed a no significant correlation of clinical profile i.e., menstrual irregularities, acne vulgaris, acanthosis nigricans and hirsutism in both groups. The waist-hip ratio was higher obese PCOS women. High levels of serum testosterone were seen in obese women with PCOS, whereas there is no correlation between other hormone like FSH, LH, TSH and LH/FSH in both study groups. Conclusions: PCOS is a risk factor for endocrinal and metabolic derangements irrespective of the BMI status. More than half of women with PCOS were obese. Increased BMI in PCOS women is associated with increased WHR and raised serum testosterone with no difference in other endocrine parameters

IDENTIFYING SUITABLE LOCATIONS FOR MANGROVE PLANTATION USING GEOSPATIAL INFORMATION SYSTEM AND REMOTE SENSING

Mangroves provide numerous environmental benefits, such as carbon sequestration, water purification, climate change mitigation, and flood and Tsunami impact reduction. Despite these unique advantages, mangroves are threatened by the combined adverse impacts of human activities and climate change. Therefore, it is essential to implement reasonable practices to avoid further degradation of mangroves and provide efficient workflows to increase their extent. Accordingly, better plantation policies are principally required for their conservation and rehabilitation. In this study, we desired to detect suitable locations for mangrove plantation in coastal areas of Hormozgan Province, Iran. We considered a relatively new Multi Criteria Decision Making (MCDM) technique to combine ten criteria derived from remote sensing in a GIS environment. The Best Worst Method (BWM), as an MDCM technique, was implemented to determine the relative importance of each criterion. Afterward, all criteria were aggregated using the Weighted Linear Combination (WLC) method to produce a mangrove plantation suitability map. Statistical measures, including Overall Accuracy (OA = 95%), Kappa Coefficient (KC = 87.9%), and Area Under Curve (AUC = 98.79%), indicated the high applicability of the implemented method for mangrove plantation site allocation. The produced map could give managers a profound insight into finding optimal spots to plant mangroves

A cross sectional study of various types of acute poisoning; pharmacological management and their outcome in a tertiary care hospital

Background: Acute poisoning is a common and life-threatening crisis, leading to serious complications and death of patients. Poisoning may be due to self-consumption, accidental exposure of chemical compounds, medications and poisonous animal bites/stings. Aim of current study was to investigate the pattern of drug utilization, poisoning agents and outcome in patients with acute poisoning treated at a tertiary care teaching hospital, Vadodara, Gujarat. Methods: This prospective cross-sectional study was done on patients of acute poisoning admitted in emergency department, SSG Hospital during August 2021-March 2022. Results: 400 patients were enrolled during the study, from which 262 (65.50%) were male and 138 (34.50%) were female. Mean age of patients was 30.30 ± 13.79 years. The commonest mode of poisoning observed was Suicidal (66.25%). The most common cause of poisoning was due to Pesticides (33.25%), followed by venomous animal exposures (30.75%). Death was recorded in 53 (13.25%) patients with highest number seen in suicidal poisoning (14.34%) compared to accidental poisonings (11.19%). Mainly, multivitamins (19.03%), Antimicrobials (16.65%), Proton Pump Inhibitors (15.85%) and Antiemetics (11.10%) were prescribed. Antidotes used were Atropine (4.81%), Pralidoxime (4.46%) and Anti-snake venom (2.80%). Median number of drugs per patient was 8; range: 2-25. Conclusions: Pattern and magnitude of poisoning are multidimensional and demand multi-sectoral approach for facing this problem. Due to high incidence of snakebites, hospital stockpiles should be regularly checked for availability of antivenom. There is a need for stringent pesticide regulation laws, counselling and training programs to reduce incidence of poisonings and deaths due to it

Effect of the centrifugal force on the electromechanical instability of U-shaped and double-sided sensors made of cylindrical nanowires

The U-shaped and double-sided nanostructures are promising for developing miniature angular speed sensors. While the electromechanical instability of conventional beam-type nanostructures has been extensively addressed in the literature, few researchers have investigated this phenomenon in the double-sided and U-shaped sensors. In this regard, the present work demonstrates the effect of the centrifugal force on the pull-in performance of the double-sided and U-shaped sensors fabricated from cylindrical nanowire and operated in the van der Waals (vdW) regime. Based on the modified couple stress theory, the size-dependent constitutive equations of the sensors are derived. The governing equations are solved by two different approaches, i.e. the analytic Duan–Adomian method and the numerical differential quadrature method. The influences of the vdW and centrifugal forces, geometric parameters and the size phenomenon on the pull-in parameters are demonstrated