Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling.

Conformational activation of integrins is generally required for ligand binding and cellular signalling. However, we have previously reported that the nonactivated conformation of α2β1 integrin can also bind to large ligands, such as human echovirus 1. In this study, we show that the interaction between the nonactivated integrin and a ligand resulted in the activation of focal adhesion kinase (FAK) in a protein kinase C dependent manner. A loss-of-function mutation, α2E336A, in the α2-integrin did not prevent the activation of FAK, nor did EDTA-mediated inactivation of the integrin. Full FAK activation was observed, since phosphorylation was not only confirmed in residue Y397, but also in residues Y576/7. Furthermore, initiation of downstream signaling by paxillin phosphorylation in residue Y118 was evident, even though this activation was transient by nature, probably due to the lack of talin involvement in FAK activation and the absence of vinculin in the adhesion complexes formed by the nonactivated integrins. Altogether these results indicate that the nonactivated integrins can induce cellular signaling, but the outcome of the signaling differs from conventional integrin signaling

Supergravity origin of the MSSM inflation

We consider the supergravity origin of the recently proposed MSSM inflationary model, which relies on the existence of a saddle point along a dimension six flat direction. We derive the conditions that the Kahler potential has to satisfy for the saddle point to exist irrespective of the hidden sector vevs. We show that these conditions are satisfied by a simple class of Kahler potentials, which we find to have a similar form as in various string theory compactifications. For these potentials, slow roll MSSM inflation requires no fine tuning of the soft supersymmetry breaking parameters.Comment: v3: 10 pages, no figures; version accepted for publication. Typos correcte

Non-Gaussianity from Instant and Tachyonic Preheating

We study non-Gaussianity in two distinct models of preheating: instant and tachyonic. In instant preheating non-Gaussianity is sourced by the local terms generated through the coupled perturbations of the two scalar fields. We find that the non-Gaussianity parameter is given by $f_{NL}^{\phi}\sim 2g < O(1)$, where $g$ is a coupling constant, so that instant preheating is unlikely to be constrained by WMAP or Planck. In the case of tachyonic preheating non-Gaussianity arises solely from the instability of the tachyon matter and is found to be large. We find that for single field inflation the present WMAP data implies a bound $V_{0}^{1/4}/M_{P}\leq 10^{-4}$ on the scale of tachyonic instability. We argue that the tachyonic preheating limits are useful also for string-motivated inflationary models.Comment: 12 pages, 1 figure, additional discussion, improved constraint on the scale of tachyonic preheatin

Kahler potentials for the MSSM inflation and the spectral index

Recently it has been argued that some of the fine-tuning problems of the MSSM inflation associated with the existence of a saddle point along a flat direction may be solved naturally in a class of supergravity models. Here we extend the analysis and show that the constraints on the Kahler potentials in these models are considerably relaxed when the location of the saddle point is treated as a free variable. We also examine the effect of supergravity corrections on inflationary predictions and find that they can slightly alter the value of the spectral index. As an example, for flat direction field values $|\bar{\phi}_0|=1\times10^{-4}M_P$ we find $n\sim0.92 ... 0.94$ while the prediction of the MSSM inflation without any corrections is $n\sim0.92$.Comment: 13 pages, one figure. Typos corrected and a reference adde

Dialogue based interfaces for universal access.

Conversation provides an excellent means of communication for almost all people. Consequently, a conversational interface is an excellent mechanism for allowing people to interact with systems. Conversational systems are an active research area, but a wide range of systems can be developed with current technology. More sophisticated interfaces can take considerable effort, but simple interfaces can be developed quite rapidly. This paper gives an introduction to the current state of the art of conversational systems and interfaces. It describes a methodology for developing conversational interfaces and gives an example of an interface for a state benefits web site. The paper discusses how this interface could improve access for a wide range of people, and how further development of this interface would allow a larger range of people to use the system and give them more functionality

Identifying the curvaton within MSSM

We consider inflaton couplings to MSSM flat directions and the thermalization of the inflaton decay products, taking into account gauge symmetry breaking due to flat direction condensates. We then search for a suitable curvaton candidate among the flat directions, requiring an early thermally induced start for the flat direction oscillations to facilitate the necessary curvaton energy density dominance. We demonstrate that the supersymmetry breaking $A$-term is crucial for achieving a successful curvaton scenario. Among the many possible candidates, we identify the ${\bf u_1dd}$ flat direction as a viable MSSM curvaton.Comment: 9 pages. Discussion on the evaporation of condensate added, final version published in JCA

Precision mass measurements on neutron-rich rare-earth isotopes at JYFLTRAP - reduced neutron pairing and implications for the rr-process calculations

The rare-earth peak in the $r$-process abundance pattern depends sensitively on both the astrophysical conditions and subtle changes in nuclear structure in the region. This work takes an important step elucidating the nuclear structure and reducing the uncertainties in $r$-process calculations via precise atomic mass measurements at the JYFLTRAP double Penning trap. $^{158}$Nd, $^{160}$Pm, $^{162}$Sm, and $^{164-166}$Gd have been measured for the first time and the precisions for $^{156}$Nd, $^{158}$Pm, $^{162,163}$Eu, $^{163}$Gd, and $^{164}$Tb have been improved considerably. Nuclear structure has been probed via two-neutron separation energies $S_{2n}$ and neutron pairing energy metrics $D_n$. The data do not support the existence of a subshell closure at $N=100$. Neutron pairing has been found to be weaker than predicted by theoretical mass models. The impact on the calculated $r$-process abundances has been studied. Substantial changes resulting in a smoother abundance distribution and a better agreement with the solar $r$-process abundances are observed.Comment: 8 pages, 4 figures, accepted for publication in Physical Review Letter

Supersymmetric Thermalization and Quasi-Thermal Universe: Consequences for Gravitinos and Leptogenesis

Motivated by our earlier paper \cite{am}, we discuss how the infamous gravitino problem has a natural built in solution within supersymmetry. Supersymmetry allows a large number of flat directions made up of {\it gauge invariant} combinations of squarks and sleptons. Out of many at least {\it one} generically obtains a large vacuum expectation value during inflation. Gauge bosons and Gauginos then obtain large masses by virtue of the Higgs mechanism. This makes the rate of thermalization after the end of inflation very small and as a result the Universe enters a {\it quasi-thermal phase} after the inflaton has completely decayed. A full thermal equilibrium is generically established much later on when the flat direction expectation value has substantially decareased. This results in low reheat temperatures, i.e., $T_{\rm R}\sim {\cal O}({\rm TeV})$, which are compatible with the stringent bounds arising from the big bang nucleosynthesis. There are two very important implications: the production of gravitinos and generation of a baryonic asymmetry via leptogenesis during the quasi-thermal phase. In both the cases the abundances depend not only on an effective temperature of the quasi-thermal phase (which could be higher, i.e., $T\gg T_{\rm R}$), but also on the state of equilibrium in the reheat plasma. We show that there is no ``thermal gravitino problem'' at all within supersymmetry and we stress on a need of a new paradigm based on a ``quasi-thermal leptogenesis'', because in the bulk of the parameter space the {\it old} thermal leptogenesis cannot account for the observed baryon asymmetry.Comment: 53 pages. Final version published in JCA