Real surface effects on radiative heat transfer

Radiative heat transfer for system of radiatively interacting opaque surfaces separated by radiatively transparent mediu

Theoretical Study of Radiant Heat Exchange for Non-gray Non-diffuse Surfaces in a Space Environment Semiannual Status Report No. 2, Aug. 1965 - Feb. 1966

Bi-directional reflectance models for describing distribution of reflected energy from rough metallic spacecraft surface

Theoretical study of radiant heat exchange for non-gray non-diffuse surfaces in a space environment Semiannual status report no. 3, Feb. - Jul. 1966

Radiant heat exchange for nongray nondiffuse surfaces in space environmen

Radiant heat exchange in a space environment Scientific technical report, 1 Feb. - 31 Jul. 1969

Analytical methods development for predicting radiant heat transfer and temperature of engineering surfaces in space environmen

Naturally occurring sendai virus infection of athymic nude mice

Nude (nu/nu) mice, Balb/c derived, responded to a naturally occurring Sendai virus infection in a different manner than conventional mice. They developed a chronic debilitating disease and a persistent viral infection of the respiratory tract with intranuclear inclusion bodies in tracheal, bronchial and bronchiolar epithelial cells, laryngeal and tracheal glandular epithelium and in type I and II alveolar cells. The infection was identified by serologic and tissue culture studies, the mouse antibody production test and ultrastructural examination of pulmonary lesions. Phlebitis of pulmonary veins, suppurative rhinitis and otitis media accompanied the viral infection while some mice developed a secondary bronchopneumonia

Rabbitpox in New Zealand White Rabbits: A Therapeutic Model for Evaluation of Poxvirus Medical Countermeasures Under the FDA Animal Rule

The elimination of smallpox as an endemic disease and the obvious ethical problems with clinical challenge requires the efficacy evaluation of medical countermeasures against smallpox using the FDA Animal Rule. This approach requires the evaluation of antiviral efficacy in an animal model whose infection recapitulates the human disease sufficiently well enough to provide predictive value of countermeasure effectiveness. The narrow host range of variola virus meant that no other animal species was sufficiently susceptible to variola to manifest a disease with predictive value. To address this dilemma, the FDA, after a public forum with virologists in December 2011, suggested the development of two animal models infected with the cognate orthopoxvirus, intradermal infection of rabbits and intranasal infection of mice, to supplement the non-human primate models in use. In this manuscript, we describe the development of an intradermal challenge model of New Zealand White rabbits with rabbitpox virus (RPXV) for poxvirus countermeasure evaluation. Lethality of RPXV was demonstrated in both 9 and 16-weeks old rabbits with an LD50 < 10 PFU. The natural history of RPXV infection was documented in both ages of rabbits by monitoring the time to onset of abnormal values in clinical data at a lethal challenge of 300 PFU. All infected animals became viremic, developed a fever, exhibited weight loss, developed secondary lesions, and were euthanized after 7 or 8 days. The 16-weeks RPXV-infected animals exhibiting similar clinical signs with euthanasia applied about a day later than for 9-weeks old rabbits. For all animals, the first two unambiguous indicators of infection were detection of viral copies by quantitative polymerase chain reaction and fever at 2 and 3 days following challenge, respectively. These biomarkers provide clinically-relevant trigger(s) for initiating therapy. The major advantage for using 16-weeks NZW rabbits is that older rabbits were more robust and less subject to stress-induced death allowing more reproducible studies

Method to predict the minimum measurement and experiment durations needed to achieve converged and significant results in a wind energy field experiment

Experiments offer incredible value to science, but results must always come with an uncertainty quantification to be meaningful. This requires grappling with sources of uncertainty and how to reduce them. In wind energy, field experiments are sometimes conducted with a control and treatment. In this scenario uncertainty due to bias errors can often be neglected as they impact both control and treatment approximately equally. However, uncertainty due to random errors propagates such that the uncertainty in the difference between the control and treatment is always larger than the random uncertainty in the individual measurements if the sources are uncorrelated. As random uncertainties are usually reduced with additional measurements, there is a need to know the minimum duration of an experiment required to reach acceptable levels of uncertainty. We present a general method to simulate a proposed experiment, calculate uncertainties, and determine both the measurement duration and the experiment duration required to produce statistically significant and converged results. The method is then demonstrated as a case study with a virtual experiment that uses real-world wind resource data and several simulated tip extensions to parameterize results by the expected difference in power. With the method demonstrated herein, experiments can be better planned by accounting for specific details such as controller switching schedules, wind statistics, and postprocess binning procedures such that their impacts on uncertainty can be predicted and the measurement duration needed to achieve statistically significant and converged results can be determined before the experiment.</p

Admission to acute care hospitals for adolescent substance abuse: a national descriptive analysis

BACKGROUND: Use of alcohol and illicit drugs by adolescents remains a problem in the U.S. Case identification and early treatment can occur within a broad variety of healthcare and non-healthcare settings, including acute care hospitals. The objective of this study is to describe the extent and nature of adolescent admissions to the acute inpatient setting for substance abuse (SA). We use the Agency for Healthcare Research and Quality (AHRQ) 2000 Healthcare Cost and Utilization Project Kids Inpatient Database (HCUP-KID) which includes over 2.5 million admissions for youth age 20 and under to 2,784 hospitals in 27 states in the year 2000. Specifically, this analysis estimates national number of admissions, mean total charges, and mean lengths of stay for adolescents between the ages of 12 and 17 admitted to an acute care hospital for the following diagnostic categories from the AHRQ's Clinical Classifications Software categories: "alcohol-related mental disorders" and "substance-related mental disorders". Frequency and percentage of total admissions were calculated for demographic variables of age, gender and income and for hospital characteristic variables of urban/rural designation and children's hospital designation. RESULTS: SA admissions represented 1.25 percent of adolescent admissions to acute care hospitals. Nearly 90 percent of the admission occurred in non-Children's hospitals. Most were for drug dependence (38%) or non-dependent use of alcohol or drugs (35%). Costs were highest for drug dependence admissions. Nearly half of admissions had comorbid mental health diagnoses. Higher rates of admission were seen in boys, in older adolescents, and in "self-pay" patients. Alcohol and drug rehabilitation/detoxification, alone or in combination with psychological and psychiatric evaluation and therapy, was documented for 38 percent of admissions. Over 50 percent of cases had no documentation of treatment specific to substance use behavior. CONCLUSION: General acute care hospitals have a significant and important opportunity to recognize, treat, and refer adolescents with substance abuse problems. These results suggest that inpatient facilities should develop and implement policies and processes to ensure that adolescent substance abusers admitted to their institutions receive appropriate care during the admission and appropriate referral to community care resources