733 research outputs found
Effects of exposure to extremely low-frequency magnetic field of 2 μT intensity on spatial memory and learning in mice
Evaluating the effect of aquatic extraction of Cannabis sativa seed on spatial memory consolidation
Evaluating the effect of Tetrahydrocannabinol (∆9-THC) extracted from Cannabis sativa plant on spatial memory consolidation in rats
Anomalous Transient Current in Nonuniform Semiconductors
Nonequilibrium processes in semiconductors are considered with highly
nonuniform initial densities of charge carriers. It is shown that there exist
such distributions of charge densities under which the electric current through
a sample displays quite abnormal behaviour flowing against the applied voltage.
The appearance of this negative electric current is a transient phenomenon
occurring at the initial stage of the process. After this anomalous negative
fluctuation, the electric current becomes normal, i.e. positive as soon as the
charge density becomes more uniform. Several possibilities for the practical
usage of this effect are suggested.Comment: 1 file, 11 pages, RevTex, no figure
Low energy excitations in crystalline perovskite oxides: Evidence from noise experiments
In this paper we report measurements of 1/f noise in a crystalline metallic
oxide with perovskite structure down to 4.2K. The results show existence of
localized excitations with average activation energy 70-80 meV which
produce peak in the noise at T 35-40K. In addition, it shows clear
evidence of tunnelling type two-level-systems (as in glasses) which show up in
noise measurements below 30K.Comment: 11 pages, 4 figures, to appear in Phys Rev B, vol 58, 1st Dec issu
Low-frequency Current Fluctuations in Individual Semiconducting Single-Wall Carbon Nanotubes
We present a systematic study on low-frequency current fluctuations of
nano-devices consisting of one single semiconducting nanotube, which exhibit
significant 1/f-type noise. By examining devices with different switching
mechanisms, carrier types (electrons vs. holes), and channel lengths, we show
that the 1/f fluctuation level in semiconducting nanotubes is correlated to the
total number of transport carriers present in the system. However, the 1/f
noise level per carrier is not larger than that of most bulk conventional
semiconductors, e.g. Si. The pronounced noise level observed in nanotube
devices simply reflects on the small number of carriers involved in transport.
These results not only provide the basis to quantify the noise behavior in a
one-dimensional transport system, but also suggest a valuable way to
characterize low-dimensional nanostructures based on the 1/f fluctuation
phenomenon
Long-range potential fluctuations and 1/f noise in hydrogenated amorphous silicon
We present a microscopic theory of the low-frequency voltage noise (known as
"1/f" noise) in micrometer-thick films of hydrogenated amorphous silicon. This
theory traces the noise back to the long-range fluctuations of the Coulomb
potential produced by deep defects, thereby predicting the absolute noise
intensity as a function of the distribution of defect activation energies. The
predictions of this theory are in very good agreement with our own experiments
in terms of both the absolute intensity and the temperature dependence of the
noise spectra.Comment: 8 pages, 3 figures, several new parts and one new figure are added,
but no conceptual revision
Small temporal asynchronies between the two eyes in binocular reading: Crosslinguistic data and the implications for ocular prevalence
The Effect of Pregnancy and Inflammatory Bowel Disease on the Pharmacokinetics of Drugs Related to Inflammatory Bowel Disease:A Systematic Literature Review
Due to ethical and practical reasons, a knowledge gap exists on the pharmacokinetics (PK) of inflammatory bowel disease (IBD)-related drugs in pregnant women with IBD. Before evidence-based dosing can be proposed, insight into the PK has to be gained to optimize drug therapy for both mother and fetus. This systematic review aimed to describe the effect of pregnancy and IBD on the PK of drugs used for IBD. One aminosalicylate study, two thiopurine studies and twelve studies with biologicals were included. Most drugs within these groups presented data over multiple moments before, during and after pregnancy, except for mesalazine, ustekinumab and golimumab. The studies for mesalazine, ustekinumab and golimumab did not provide enough data to demonstrate an effect of pregnancy on concentration and PK parameters. Therefore, no evidence-based dosing advice was given. The 6-thioguanine nucleotide levels decreased during pregnancy to 61% compared to pre-pregnancy levels. The potentially toxic metabolite 6-methylmercaptopurine (6-MMP) increased to maximal 209% of the pre-pregnancy levels. Although the PK of the thiopurines changed throughout pregnancy, no evidence-based dosing advice was provided. One study suggested that caution should be exercised when the thiopurine dose is adjusted, due to shunting 6-MMP levels. For the biologicals, infliximab levels increased, adalimumab stayed relatively stable and vedolizumab levels tended to decrease during pregnancy. Although the PK of the biologicals changed throughout pregnancy, no evidence-based dosing advice for biologicals was provided. Other drugs retrieved from the literature search were mesalazine, ustekinumab and golimumab. We conclude that limited studies have been performed on PK parameters during pregnancy for drugs used in IBD. Therefore, more extensive research to determine the values of PK parameters is warranted. After gathering the PK data, evidence-based dosing regimens can be developed
- …