1,763 research outputs found
Broadband laser cooling of trapped atoms with ultrafast pulses
We demonstrate broadband laser cooling of atomic ions in an rf trap using
ultrafast pulses from a modelocked laser. The temperature of a single ion is
measured by observing the size of a time-averaged image of the ion in the known
harmonic trap potential. While the lowest observed temperature was only about 1
K, this method efficiently cools very hot atoms and can sufficiently localize
trapped atoms to produce near diffraction-limited atomic images
Time-dependent calculation of ionization in Potassium at mid-infrared wavelengths
We study the dynamics of the Potassium atom in the mid-infrared, high
intensity, short laser pulse regime. We ascertain numerical convergence by
comparing the results obtained by the direct expansion of the time-dependent
Schroedinger equation onto B-Splines, to those obtained by the eigenbasis
expansion method. We present ionization curves in the 12-, 13-, and 14-photon
ionization range for Potassium. The ionization curve of a scaled system, namely
Hydrogen starting from the 2s, is compared to the 12-photon results. In the
13-photon regime, a dynamic resonance is found and analyzed in some detail. The
results for all wavelengths and intensities, including Hydrogen, display a
clear plateau in the peak-heights of the low energy part of the Above Threshold
Ionization (ATI) spectrum, which scales with the ponderomotive energy Up, and
extends to 2.8 +- 0.5 Up.Comment: 15 two-column pages with 15 figures, 3 tables. Accepted for
publication in Phys. Rev A. Improved figures, language and punctuation, and
made minor corrections. We also added a comparison to the ADK theor
Predicting toxicity through computers: a changing world
The computational approaches used to predict toxicity are evolving rapidly, a process hastened on by the emergence of new ways of describing chemical information. Although this trend offers many opportunities, new regulations, such as the European Community's 'Registration, Evaluation, Authorisation and Restriction of Chemicals' (REACH), demand that models be ever more robust
Resonant enhancements of high-order harmonic generation
Solving the one-dimensional time-dependent Schr\"odinger equation for simple
model potentials, we investigate resonance-enhanced high-order harmonic
generation, with emphasis on the physical mechanism of the enhancement. By
truncating a long-range potential, we investigate the significance of the
long-range tail, the Rydberg series, and the existence of highly excited states
for the enhancements in question. We conclude that the channel closings typical
of a short-range or zero-range potential are capable of generating essentially
the same effects.Comment: 7 pages revtex, 4 figures (ps files
The inevitable QSAR renaissance
QSAR approaches, including recent advances in 3D-QSAR, are advantageous during the lead optimization phase of drug discovery and complementary with bioinformatics and growing data accessibility. Hints for future QSAR practitioners are also offered
Resonant Structures in the Low-Energy Electron Continuum for Single Ionization of Atoms in the Tunneling Regime
We present results of high-resolution experiments on single ionization of He,
Ne and Ar by ultra-short (25 fs, 6 fs) 795 nm laser pulses at intensities
0.15-2.0x10^15 W/cm^2. We show that the ATI-like pattern can survive deep in
the tunneling regime and that the atomic structure plays an important role in
the formation of the low-energy photoelectron spectra even at high intensities.
The absence of ponderomotive shifts, the splitting of the peaks and their
degeneration for few-cycle pulses indicate that the observed structures
originate from a resonant process.Comment: 11 pages, 3 figure
Automated High-resolution Earth Observation Image Interpretation: Outcome of the 2020 Gaofen Challenge
In this article, we introduce the 2020 Gaofen Challenge and relevant scientific outcomes. The 2020 Gaofen Challenge is an international competition, which is organized by the China High-Resolution Earth Observation Conference Committee and the Aerospace Information Research Institute, Chinese Academy of Sciences and technically cosponsored by the IEEE Geoscience and Remote Sensing Society and the International Society for Photogrammetry and Remote Sensing. It aims at promoting the academic development of automated high-resolution earth observation image interpretation. Six independent tracks have been organized in this challenge, which cover the challenging problems in the field of object detection and semantic segmentation. With the development of convolutional neural networks, deep-learning-based methods have achieved good performance on image interpretation. In this article, we report the details and the best-performing methods presented so far in the scope of this challenge
Hydrazone chelators for the treatment of iron overload disorders: iron coordination chemistry and biological activity
The potentially tridentate ligand 2-pyridinecarbaldehyde isonicotinoyl hydrazone (HPCIH) and its analogues are an emerging class of orally effective Fe chelators that show great promise for the treatment of Fe overload diseases. Herein, we present an extensive study of the Fe coordination chemistry of the HPCIH analogues including the first crystallographically characterised Fe-II complex of these chelators. Unlike most other clinically effective Fe chelators, the HPCIH analogues bind Fe-II and not F-III. In fact, these chelators form low-spin bis-ligand F-II complexes, although NMR suggests that the complexes are close to the high-spin/low-spin crossover. All the Fe complexes show a high potential Fe-III/(II) redox couple (> 500 mV vs. NHE) and cyclic voltammetry in aqueous or mixed aqueous/organic solvents is irreversible as a consequence of a rapid hydration reaction that occurs upon oxidation. A number of the HPCIH analogues show high activity at inducing Fe efflux from cells and also at preventing Fe uptake by cells from the serum Fe transport protein transferrin. As a class of ligands, these chelators are more effective at reducing Fe uptake from transferrin than inducing Fe mobilisation from cells. This may be related to their ability to intercept Fe-II after its release from transferrin within the cell. Our studies indicate that their Fe chelation efficacy is due, at least in part, to the fact that these ligands and their Fe-II complexes are neutral at physiological pH (7.4) and sufficiently lipophilic to permeate cell membranes
Accurate optical frequency-interval measurement by use of nonresonant frequency comb generation
A novel technique for measuring the separation of widely spaced optical frequencies is demonstrated. It relies on frequency comb generation by use of a laser that incorporates a frequency-shifting element. A Nd:YLF laser is used to produce a frequency comb that has a bandwidth of 140 GHz and that contains in excess of 875 discrete frequencies, accurately spaced by 160 MHz. The longitudinal mode spacing of a dual-frequency laser was measured to an accuracy of ±5 kHz in 3,733,440.0 kHz by use of the technique described here
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