Effect of entropy on the dynamics of supercooled liquids: New results from high pressure data

We show that for arbitrary thermodynamic conditions, master curves of the entropy are obtained by expressing S(T,V) as a function of TV^g_G, where T is temperature, V specific volume, and g_G the thermodynamic Gruneisen parameter. A similar scaling is known for structural relaxation times,tau = f(TV^g); however, we find g_G < g. We show herein that this inequality reflects contributions to S(T,V) from processes, such as vibrations and secondary relaxations, that do not directly influence the supercooled dynamics. An approximate method is proposed to remove these contributions, S_0, yielding the relationship tau = f(S-S_0).Comment: 10 pages 7 figure

Hydrothermal Friction Experiments on Simulated Basaltic Fault Gouge and Implications for Megathrust Earthquakes

Nucleation of earthquake slip at the plate boundary fault (décollement) in subduction zones has been widely linked to the frictional properties of subducting sedimentary facies. However, recent seismological and geological observations suggest that the décollement develops in the subducting oceanic crust in the depth range of the seismogenic zone, at least in some cases. To understand the frictional properties of oceanic crustal material and their influence on seismogenesis, we performed hydrothermal friction experiments on simulated fault gouges of altered basalt, at temperatures of 100–550°C. The friction coefficient (μ) lies around 0.6 at most temperature conditions but a low μ down to 0.3 was observed at the highest temperature and lowest velocity condition. The velocity dependence of μ, (a−b), changes with increasing temperature from positive to negative at ∼100°C and from negative to positive at ∼450°C. Compared to gouges derived from sedimentary facies, the altered basalt gouge showed potentially unstable velocity weakening over a wider temperature range. Microstructural observations and microphysical interpretation infer that competition between dilatant granular flow and viscous compaction through pressure-solution creep of albite contributed to the observed transition in (a−b). Alteration of oceanic crust during subduction produces fine grains of albite and chlorite through interactions with interstitial water, leading to reduction in its frictional strength and an increase in its seismogenic potential. Therefore, shear deformation possibly localizes within the altered oceanic crust leading to a larger potential for the nucleation of a megathrust earthquake in the depth range of the seismogenic zone

Loss of STOP Protein Impairs Peripheral Olfactory Neurogenesis

International audienceIn conclusion, STOP protein seems to be involved in the establishment of synapses in the olfactory glomerulus. Our results indicate that the olfactory system of STOP null mice is a well-suited experimental model (1) for the study of the mechanism of action of STOP protein in synaptic function/plasticity and (2) for pathophysiological studies of the mechanisms of altered neuronal connections in schizophrenia

Facial skin pores: a multiethnic study

Frederic Flament,1 Ghislain Francois,1 Huixia Qiu,2 Chengda Ye,2 Tomoo Hanaya,3 Dominique Batisse,3 Suzy Cointereau-Chardon,1 Mirela Donato Gianeti Seixas,4 Susi Elaine Dal Belo,4 Roland Bazin5 1Department of Applied Research and Development, L&rsquo;Oreal Research and Innovation, Paris, France; 2Department of Applied Research and Development, L&rsquo;Oreal Research and Innovation, Shanghai, People&rsquo;s Republic of China; 3Department of Applied Research and Development, L&rsquo;Oreal Research and Innovation, Tokyo, Japan; 4Department of Applied Research and Development, L&rsquo;Oreal Research and Innovation, Rio de Janeiro, Brazil; 5RB Consult, Bievres, France Abstract: Skin pores (SP), as they are called by laymen, are common and benign features mostly located on the face (nose, cheeks, etc) that generate many aesthetic concerns or complaints. Despite the prevalence of skin pores, related literature is scarce. With the aim of describing the prevalence of skin pores and anatomic features among ethnic groups, a dermatoscopic instrument, using polarized lighting, coupled to a digital camera recorded the major features of skin pores (size, density, coverage) on the cheeks of 2,585 women in different countries and continents. A detection threshold of 250 &micro;m, correlated to clinical scorings by experts, was input into a specific software to further allow for automatic counting of the SP density (N/cm2) and determination of their respective sizes in mm2. Integrating both criteria also led to establishing the relative part of the skin surface (as a percentage) that is actually covered by SP on cheeks. The results showed that the values of respective sizes, densities, and skin coverage: 1) were recorded in all studied subjects; 2) varied greatly with ethnicity; 3) plateaued with age in most cases; and 4) globally reflected self-assessment by subjects, in particular those who self-declare having &ldquo;enlarged pores&rdquo; like Brazilian women. Inversely, Chinese women were clearly distinct from other ethnicities in having very low density and sizes. Analyzing the present results suggests that facial skin pore&rsquo;s morphology as perceived by human eye less result from functional criteria of associated appendages such as sebaceous glands. To what extent skin pores may be viewed as additional criteria of a photo-altered skin is an issue to be further addressed. Keywords: aging, clinical evaluation, ethnicity, imperfections, oily ski

A companion to the preclinical common data elements and case report forms for rodent EEG studies. A report of the TASK3 EEG Working Group of the ILAE/AES Joint Translational Task Force

Electroencephalography (EEG) is commonly used in epilepsy and neuroscience research to study brain activity. The principles of EEG recording such as signal acquisition, digitization, and conditioning share similarities between animal and clinical EEG systems. In contrast, preclinical EEG studies demonstrate more variability and diversity than clinical studies in the types and locations of EEG electrodes, methods of data analysis, and scoring of EEG patterns and associated behaviors. The TASK3 EEG working group of the International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force has developed a set of preclinical common data elements (CDEs) and case report forms (CRFs) for recording, analysis, and scoring of animal EEG studies. This companion document accompanies the first set of proposed preclinical EEG CRFs and is intended to clarify the CDEs included in these worksheets. We provide 7 CRF and accompanying CDE modules for use by the research community, covering video acquisition, electrode information, experimental scheduling, and scoring of EEG activity. For ease of use, all data elements and input ranges are defined in supporting Excel charts (Appendix&nbsp;S1)