On a zero speed sensitive cellular automaton

Using an unusual, yet natural invariant measure we show that there exists a sensitive cellular automaton whose perturbations propagate at asymptotically null speed for almost all configurations. More specifically, we prove that Lyapunov Exponents measuring pointwise or average linear speeds of the faster perturbations are equal to zero. We show that this implies the nullity of the measurable entropy. The measure m we consider gives the m-expansiveness property to the automaton. It is constructed with respect to a factor dynamical system based on simple "counter dynamics". As a counterpart, we prove that in the case of positively expansive automata, the perturbations move at positive linear speed over all the configurations

QCD and the Chiral Critical Point

As an extension of $QCD$, consider a theory with ``$2+1$'' flavors, where the current quark masses are held in a fixed ratio as the overall scale of the quark masses is varied. At nonzero temperature and baryon density it is expected that in the chiral limit the chiral phase transition is of first order. Increasing the quark mass from zero, the chiral transition becomes more weakly first order, and can end in a chiral critical point. We show that the only massless field at the chiral critical point is a sigma meson, with the universality class that of the Ising model. Present day lattice simulations indicate that $QCD$ is (relatively) near to the chiral critical point.Comment: 7 pages + 2 figures, BNL-GGP-

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity.

Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse activity. M. tuberculosis and Escherichia coli PZAses (PZAse-MT and PZAse-EC, respectively) were inactivated by metal depletion (giving PZAse-MT-Apo and PZAse-EC-Apo). Reactivation with the E. coli metallochaperone ZnuA or Rv2059 (the M. tuberculosis analog) was measured. This was repeated following proteolytic and thermal treatment of ZnuA and Rv2059. The CDC1551 M. tuberculosis reference strain had the Rv2059 coding gene knocked out, and PZA susceptibility and the pyrazinoic acid (POA) efflux rate were measured. ZnuA (200 μM) achieved 65% PZAse-EC-Apo reactivation. Rv2059 (1 μM) and ZnuA (1 μM) achieved 69% and 34.3% PZAse-MT-Apo reactivation, respectively. Proteolytic treatment of ZnuA and Rv2059 and application of three (but not one) thermal shocks to ZnuA significantly reduced the capacity to reactivate PZAse-MT-Apo. An M. tuberculosis Rv2059 knockout strain was Wayne positive and susceptible to PZA and did not have a significantly different POA efflux rate than the reference strain, although a trend toward a lower efflux rate was observed after knockout. The metallochaperone Rv2059 restored the activity of metal-depleted PZAse in vitro Although Rv2059 is important in vitro, it seems to have a smaller effect on PZA susceptibility in vivo. It may be important to mechanisms of action and resistance to pyrazinamide in M. tuberculosis Further studies are needed for confirmation.IMPORTANCE Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis and remains one of the major causes of disease and death worldwide. Pyrazinamide is a key drug used in the treatment of tuberculosis, yet its mechanism of action is not fully understood, and testing strains of M. tuberculosis for pyrazinamide resistance is not easy with the tools that are presently available. The significance of the present research is that a metallochaperone-like protein may be crucial to pyrazinamide's mechanisms of action and of resistance. This may support the development of improved tools to detect pyrazinamide resistance, which would have significant implications for the clinical management of patients with tuberculosis: drug regimens that are appropriately tailored to the resistance profile of a patient's individual strain lead to better clinical outcomes, reduced onward transmission of infection, and reduction of the development of resistant strains that are more challenging and expensive to treat

τ→ρππν\tau\to\rho\pi\pi\nu decays

Effective chiral theory of mesons is applied to study the four decay modes of $\tau\to\rho\pi\pi\nu$. Theoretical values of the branching ratios are in agreement with the data. The theory predicts that the $a_{1}$ resonance plays a dominant role in these decays. There is no new parameter in this study.Comment: 12 pages and one figur

Seabird Bycatch in Pelagic Longline Fisheries Is Grossly Underestimated when Using Only Haul Data

Hundreds of thousands of seabirds are killed each year as bycatch in longline fisheries. Seabirds are predominantly caught during line setting but bycatch is generally recorded during line hauling, many hours after birds are caught. Bird loss during this interval may lead to inaccurate bycatch information. In this 15 year study, seabird bycatch was recorded during both line setting and line hauling from four fishing regions: Indian Ocean, Southern Ocean, Coral Sea and central Pacific Ocean. Over 43,000 albatrosses, petrels and skuas representing over 25 species were counted during line setting of which almost 6,000 seabirds attempted to take the bait. Bait-taking interactions were placed into one of four categories. (i) The majority (57%) of bait-taking attempts were “unsuccessful” involving seabirds that did not take the bait nor get caught or hooked. (ii) One-third of attempts were “successful” with seabirds removing the bait while not getting caught. (iii) One-hundred and seventy-six seabirds (3% of attempts) were observed being “caught” during line setting, with three albatross species – Laysan (Phoebastria immutabilis), black-footed (P. nigripes) and black-browed (Thalassarche melanophrys)– dominating this category. However, of these, only 85 (48%) seabird carcasses were retrieved during line hauling. Most caught seabirds were hooked through the bill. (iv) The remainder of seabird-bait interactions (7%) was not clearly observed, but likely involved more “caught” seabirds. Bait taking attempts and percentage outcome (e.g. successful, caught) varied between seabird species and was not always related to species abundance around fishing vessels. Using only haul data to calculate seabird bycatch grossly underestimates actual bycatch levels, with the level of seabird bycatch from pelagic longline fishing possibly double what was previously thought

η−η′\eta-\eta^\prime mixing and the next-to-leading-order power correction

The next-to-leading-order $O(1/Q^4)$ power correction for $\eta\gamma$ and $\eta^\prime\gamma$ form factors are evaluated and employed to explore the $\eta-\eta^\prime$ mixing. The parameters of the two mixing angle scheme are extracted from the data for form factors, two photon decay widths and radiative $J/\psi$ decays. The $\chi^2$ analysis gives the result: $f_{\eta_1}=(1.16\pm0.06)f_\pi, f_{\eta_8}=(1.33\pm0.23)f_\pi, \theta_1=-9^\circ\pm 3^\circ, \theta_8=-21.3^\circ\pm 2.3^\circ$, where $f_{\eta_{1(8)}}$ and $\theta_{1(8)}$ are the decay constants and the mixing angles for the singlet (octet) state. In addition, we arrive at a stringent range for $f_{\eta^\prime}^c:-10$ MeV$\le f_{\eta^\prime}^c\le -4$ MeV.Comment: 23 pages, 9 figures, To be publshied in Phys. Rev.

COVID-19 in Latin America: Novel transmission dynamics for a global pandemic?

The COVID-19 virus expanded from China into Western Asia, Europe, and North America, impacting many of the world’s wealthiest countries. Brazil reported Latin America’s first case in late February 2020, and in less than a month, over 7,000 COVID-19 cases have been confirmed among nearly every country and territory in Latin America and the Caribbean (LAC). The LAC outbreak appears to be about two weeks behind the United States and Canada and about three to four weeks behind Western Europe. Thus, the global COVID-19 pandemic is entering a new phase, not only expanding beyond primarily temperate Northern Hemisphere countries into the tropics but also spreading to a geopolitical region marked by significantly worse poverty, water access and sanitation, and distrust in public governance (Fig 1). We believe that these aspects of the Latin American context are likely to substantially affect the transmission dynamics and scope of the COVID-19 outbreak in LAC, with potential implications for the trajectory of the global pandemic.The COVID-19 virus expanded from China into Western Asia, Europe, and North America, impacting many of the world’s wealthiest countries. Brazil reported Latin America’s first case in late February 2020, and in less than a month, over 7,000 COVID-19 cases have been confirmed among nearly every country and territory in Latin America and the Caribbean (LAC). The LAC outbreak appears to be about two weeks behind the United States and Canada and about three to four weeks behind Western Europe. Thus, the global COVID-19 pandemic is entering a new phase, not only expanding beyond primarily temperate Northern Hemisphere countries into the tropics but also spreading to a geopolitical region marked by significantly worse poverty, water access and sanitation, and distrust in public governance (Fig 1). We believe that these aspects of the Latin American context are likely to substantially affect the transmission dynamics and scope of the COVID-19 outbreak in LAC, with potential implications for the trajectory of the global pandemic

Hypertension among adults in a deprived urban area of Peru – Undiagnosed and uncontrolled?

BACKGROUND: In Peru, cardiovascular disease was the second most common cause of death in those aged 65 years or more in 2000. Hypertension is a major modifiable risk factor for cardiovascular disease, and if treated can significantly reduce cardiovascular disease risk. The objectives of this study were to investigate the prevalence of hypertension and levels of awareness, treatment and control in a deprived urban area of Peru. METHODS: A cross-sectional study was completed. Blood pressure measurements were recorded in triplicate. Hypertension was defined as systolic blood pressure >/= 140 mmHg or diastolic blood pressure >/= 90 mmHg, or self report of receiving antihypertensive medication at the time of interview. RESULTS: The study sample was 584 adults (29.1% male, mean age 35.3 years). Age standardized prevalence of hypertension was 19.5% (95% CI 9.9%, 29.1%) in men, 11.4% (95% CI 3.7%, 19.1%) in women, and 13.2% (95% CI 5.0%, 21.5%) overall. Among those with hypertension 38.3% (95% CI 22.7%, 53.9%, n = 18/47) were aware of their condition with greater awareness among women than men. Of those aware, 61.1% (n = 11/18) were treated, equating to 23.4% (95% CI 10.1%, 36.7%, n = 11/47) of all adults with hypertension. Of those treated 63.6% (n = 7/11) had controlled hypertension, equating to 14.9% (95% CI 3.0%, 26.8%, n = 7/47) of all adults with hypertension. CONCLUSION: Levels of awareness and control in this population were low. Lack of control is likely to be due to both a failure to diagnose hypertension, especially among men, and initiate or comply with treatment, especially among women. These results suggest a considerable burden of undiagnosed hypertension, and poor levels of control in those treated, in a deprived urban area of Lima, Peru

Chiral effective theory predictions for deuteron form factor ratios at low Q^2

We use chiral effective theory to predict the deuteron form factor ratio G_C/G_Q as well as ratios of deuteron to nucleon form factors. These ratios are calculated to next-to-next-to-leading order. At this order the chiral expansion for the NN isoscalar charge operator (including consistently calculated 1/M corrections) is a parameter-free prediction of the effective theory. Use of this operator in conjunction with NLO and NNLO chiral effective theory wave functions produces results that are consistent with extant experimental data for Q^2 < 0.35 GeV^2. These wave functions predict a deuteron quadrupole moment G_Q(Q^2=0)=0.278-0.282 fm^2-with the variation arising from short-distance contributions to this quantity. The variation is of the same size as the discrepancy between the theoretical result and the experimental value. This motivates the renormalization of G_Q via a two-nucleon operator that couples to quadrupole photons. After that renormalization we obtain a robust prediction for the shape of G_C/G_Q at Q^2 < 0.3 GeV^2. This allows us to make precise, model-independent predictions for the values of this ratio that will be measured at the lower end of the kinematic range explored at BLAST. We also present results for the ratio G_C/G_M.Comment: 31 pages, 7 figure