3,184 research outputs found
Recommended from our members
STONE 6: Artificial Sedimentary Meteorites in Space
The STONE 6 experiment demonstrated the survivability of carbonaceous and microfossiliferous martian analogue sediments during atmospheric re-entry. Doped endoliths died but their carbonised cells remained
Equation of State, Spectra and Composition of Hot and Dense Infinite Hadronic Matter in a Microscopic Transport Model
Equilibrium properties of infinite relativistic hadron matter are
investigated using the Ultrarelativistic Quantum Molecular Dynamics (UrQMD)
model. The simulations are performed in a box with periodic boundary
conditions. Equilibration times depend critically on energy and baryon
densities. Energy spectra of various hadronic species are shown to be isotropic
and consistent with a single temperature in equilibrium. The variation of
energy density versus temperature shows a Hagedorn-like behavior with a
limiting temperature of 13010 MeV. Comparison of abundances of different
particle species to ideal hadron gas model predictions show good agreement only
if detailed balance is implemented for all channels. At low energy densities,
high mass resonances are not relevant; however, their importance raises with
increasing energy density. The relevance of these different conceptual
frameworks for any interpretation of experimental data is questioned.Comment: Latex, 20 pages including 6 eps-figure
Local Thermal and Chemical Equilibration and the Equation of State in Relativistic Heavy Ion Collisions
Thermodynamical variables and their time evolution are studied for central
relativistic heavy ion collisions from 10.7 to 160 AGeV in the microscopic
Ultrarelativistic Quantum Molecular Dynamics model (UrQMD). The UrQMD model
exhibits drastic deviations from equilibrium during the early high density
phase of the collision. Local thermal and chemical equilibration of the
hadronic matter seems to be established only at later stages of the quasi-
isentropic expansion in the central reaction cell with volume 125 fm.
distributions at all collision energies for with a unique
Baryon energy spectra in this cell are approximately reproduced by Boltzmann
rapidly dropping temperature. At these times the equation of state has a simple
form: . At 160 AGeV the strong deviation from
chemical equilibrium is found for mesons, especially for pions, even at the
late stage of the reaction. The final enhancement of pions is supported by
experimental data.Comment: 17 Pages, LaTex, 8 eps figures. Talk given at SQM'98 conference,
20-24 July 1998, Padova, Italy, submitted to J. Phys.
Are we close to the QGP? - Hadrochemical vs. microscopic analysis of particle production in ultrarelativistic heavy ion collisions
Ratios of hadronic abundances are analyzed for pp and nucleus-nucleus
collisions at sqrt(s)=20 GeV using the microscopic transport model UrQMD.
Secondary interactions significantly change the primordial hadronic cocktail of
the system. A comparison to data shows a strong dependence on rapidity. Without
assuming thermal and chemical equilibrium, predicted hadron yields and ratios
agree with many of the data, the few observed discrepancies are discussed.Comment: 12 pages, 4 figure
Structure-Activity Relationships of Triple-Action Platinum(IV) Prodrugs with Albumin-Binding Properties and Immunomodulating Ligands
Chemotherapy with
platinum complexes is essential for clinical
anticancer therapy. However, due to side effects and drug resistance,
further drug improvement is urgently needed. Herein, we report on
triple-action platinum(IV) prodrugs, which, in addition to tumor targeting via maleimide-mediated albumin binding, release the immunomodulatory
ligand 1-methyl-d-tryptophan (1-MDT). Unexpectedly, structure–activity
relationship analysis showed that the mode of 1-MDT conjugation distinctly
impacts the reducibility and thus activation of the prodrugs. This
in turn affected ligand release, pharmacokinetic properties, efficiency
of immunomodulation, and the anticancer activity in vitro and in a mouse model in vivo. Moreover, we could
demonstrate that the design of albumin-targeted multi-modal prodrugs
using platinum(IV) is a promising strategy to enhance the cellular
uptake of bioactive ligands with low cell permeability (1-MDT) and
to improve their selective delivery into the malignant tissue. This
will allow tumor-specific anticancer therapy supported by a favorably
tuned immune microenvironment
Recommended from our members
Measurement of double-differential cross sections for top quark pair production in pp collisions at [Formula: see text][Formula: see text] and impact on parton distribution functions.
Normalized double-differential cross sections for top quark pair ([Formula: see text]) production are measured in pp collisions at a centre-of-mass energy of 8[Formula: see text] with the CMS experiment at the LHC. The analyzed data correspond to an integrated luminosity of 19.7[Formula: see text]. The measurement is performed in the dilepton [Formula: see text] final state. The [Formula: see text] cross section is determined as a function of various pairs of observables characterizing the kinematics of the top quark and [Formula: see text] system. The data are compared to calculations using perturbative quantum chromodynamics at next-to-leading and approximate next-to-next-to-leading orders. They are also compared to predictions of Monte Carlo event generators that complement fixed-order computations with parton showers, hadronization, and multiple-parton interactions. Overall agreement is observed with the predictions, which is improved when the latest global sets of proton parton distribution functions are used. The inclusion of the measured [Formula: see text] cross sections in a fit of parametrized parton distribution functions is shown to have significant impact on the gluon distribution
Recommended from our members
A search for new phenomena in pp collisions at [Formula: see text] in final states with missing transverse momentum and at least one jet using the [Formula: see text] variable.
A search for new phenomena is performed in final states containing one or more jets and an imbalance in transverse momentum in pp collisions at a centre-of-mass energy of 13[Formula: see text]. The analysed data sample, recorded with the CMS detector at the CERN LHC, corresponds to an integrated luminosity of 2.3[Formula: see text]. Several kinematic variables are employed to suppress the dominant background, multijet production, as well as to discriminate between other standard model and new physics processes. The search provides sensitivity to a broad range of new-physics models that yield a stable weakly interacting massive particle. The number of observed candidate events is found to agree with the expected contributions from standard model processes, and the result is interpreted in the mass parameter space of fourteen simplified supersymmetric models that assume the pair production of gluinos or squarks and a range of decay modes. For models that assume gluino pair production, masses up to 1575 and 975[Formula: see text] are excluded for gluinos and neutralinos, respectively. For models involving the pair production of top squarks and compressed mass spectra, top squark masses up to 400[Formula: see text] are excluded
Recommended from our members
Search for new phenomena with the MT2 variable in the all-hadronic final state produced in proton-proton collisions at s=13 TeV.
A search for new phenomena is performed using events with jets and significant transverse momentum imbalance, as inferred through the MT2 variable. The results are based on a sample of proton-proton collisions collected in 2016 at a center-of-mass energy of 13 TeV with the CMS detector and corresponding to an integrated luminosity of 35.9 fb-1 . No excess event yield is observed above the predicted standard model background, and the results are interpreted as exclusion limits at 95% confidence level on the masses of predicted particles in a variety of simplified models of R-parity conserving supersymmetry. Depending on the details of the model, 95% confidence level lower limits on the gluino (light-flavor squark) masses are placed up to 2025 (1550) GeV . Mass limits as high as 1070 (1175) GeV are set on the masses of top (bottom) squarks. Information is provided to enable re-interpretation of these results, including model-independent limits on the number of non-standard model events for a set of simplified, inclusive search regions
- …