Just Adapt: Engaging Disadvantaged Young People in Planning for Climate Adaptation

The visibility of young people in climate change debates has risen significantly since the inception of the Fridays for Future movement, but little is known about the diversity of positions, perspectives and experiences of young people in Ireland, especially with respect to climate change adaptation planning. To close this knowledge gap, this article first interrogates key emergent spaces of public participation within the arena of climate action in Ireland in order to identify the extent of young people’s participation and whether any specific consideration is given to disadvantaged groups. It then tests the impacts of workshops specifically designed to support disadvantaged young people’s engagement with climate change adaptation which were rolled out with a designated Delivering Equality of Opportunity in Schools school in inner-city Dublin, Ireland. We found limited attention to public participation in climate change adaptation planning generally, with even less consideration given to engaging young people from disadvantaged communities. However, positive impacts with respect to enhanced knowledge of climate change science and policy processes emerged following participation in the workshops, providing the bedrock for a greater sense of self-efficacy around future engagement with climate action amongst the young people involved. We conclude that what is needed to help ensure procedural justice around climate action in Ireland are specific, relevant and interactive educational interventions on the issue of climate change adaptation; interventions which are sensitive to matters of place and difference

Recollements of Module Categories

We establish a correspondence between recollements of abelian categories up to equivalence and certain TTF-triples. For a module category we show, moreover, a correspondence with idempotent ideals, recovering a theorem of Jans. Furthermore, we show that a recollement whose terms are module categories is equivalent to one induced by an idempotent element, thus answering a question by Kuhn.Comment: Comments are welcom

Bosonic self-energy functional theory

We derive the self-energy functional theory for bosonic lattice systems with broken U(1) symmetry by parametrizing the bosonic Baym-Kadanoff effective action in terms of one- and two-point self-energies. The formalism goes beyond other approximate methods such as the pseudoparticle variational cluster approximation, the cluster composite boson mapping, and the Bogoliubov+U theory. It simplifies to bosonic dynamical-mean-field theory when constraining to local fields, whereas when neglecting kinetic contributions of noncondensed bosons, it reduces to the static mean-field approximation. To benchmark the theory, we study the Bose-Hubbard model on the two- and three-dimensional cubic lattice, comparing with exact results from path integral quantum Monte Carlo. We also study the frustrated square lattice with next-nearest-neighbor hopping, which is beyond the reach of Monte Carlo simulations. A reference system comprising a single bosonic state, corresponding to three variational parameters, is sufficient to quantitatively describe phase boundaries and thermodynamical observables, while qualitatively capturing the spectral functions, as well as the enhancement of kinetic fluctuations in the frustrated case. On the basis of these findings, we propose self-energy functional theory as the omnibus framework for treating bosonic lattice models, in particular, in cases where path integral quantum Monte Carlo methods suffer from severe sign problems (e.g., in the presence of nontrivial gauge fields or frustration). Self-energy functional theory enables the construction of diagrammatically sound approximations that are quantitatively precise and controlled in the number of optimization parameters but nevertheless remain computable by modest means

Anisotropic Harper-Hofstadter-Mott model: Competition between condensation and magnetic fields

We derive the reciprocal cluster mean-field method to study the strongly interacting bosonic Harper-Hofstadter-Mott model. The system exhibits a rich phase diagram featuring band insulating, striped superfluid, and supersolid phases. Furthermore, for finite hopping anisotropy, we observe gapless uncondensed liquid phases at integer fillings, which are analyzed by exact diagonalization. The liquid phases at fillings ν=1,3 exhibit the same band fillings as the fermionic integer quantum Hall effect, while the phase at ν=2 is CT-symmetric with zero charge response. We discuss how these phases become gapped on a quasi-one-dimensional cylinder, leading to a quantized Hall response, which we characterize by introducing a suitable measure for nontrivial many-body topological properties. Incompressible metastable states at fractional filling are also observed, indicating competing fractional quantum Hall phases. The combination of reciprocal cluster mean-field and exact diagonalization yields a promising method to analyze the properties of bosonic lattice systems with nontrivial unit cells in the thermodynamic limit

Auslander-Buchweitz approximation theory for triangulated categories

We introduce and develop an analogous of the Auslander-Buchweitz approximation theory (see \cite{AB}) in the context of triangulated categories, by using a version of relative homology in this setting. We also prove several results concerning relative homological algebra in a triangulated category \T, which are based on the behavior of certain subcategories under finiteness of resolutions and vanishing of Hom-spaces. For example: we establish the existence of preenvelopes (and precovers) in certain triangulated subcategories of \T. The results resemble various constructions and results of Auslander and Buchweitz, and are concentrated in exploring the structure of a triangulated category \T equipped with a pair (\X,\omega), where \X is closed under extensions and $\omega$ is a weak-cogenerator in \X, usually under additional conditions. This reduces, among other things, to the existence of distinguished triangles enjoying special properties, and the behavior of (suitably defined) (co)resolutions, projective or injective dimension of objects of \T and the formation of orthogonal subcategories. Finally, some relationships with the Rouquier's dimension in triangulated categories is discussed.Comment: To appear at: Appl. Categor. Struct. (2011); 22 page

Identification of importin alpha 7 specific transport cargoes using a proteomic screening approach

The importin alpha:beta complex is responsible for the nuclear import of proteins bearing classical nuclear localization signals. In mammals several importin alpha subtypes are known to exist which are suggested to have individual functions. Importin alpha 7 was shown to play a crucial role in early embryo development in mice. Embryos from importin alpha 7 depleted females stop at the two-cell stage and show disturbed zygotic genome activation. Since there is evidence that individual importin alpha subtypes possess cargo specificities, we hypothesized that importin alpha 7 binds a unique set of intracellular proteins. By using a collection of in vitro and in vivo binding assays, importin alpha 7 interaction partners were identified that differed from proteins found to bind to importin alpha 2 and 3. One of the proteins preferentially binding importin alpha 7 was the maternal effect protein Brg1. However, Brg1 was localized in oocyte nuclei in importin alpha 7 deficient embryos, albeit in reduced amounts, suggesting additional modes of nuclear translocation of this factor. An additional SILAC based screening approach identified Ash2l, Chd3, Mcm3, and Smarcc1 whose nuclear import seems to be disturbed in importin alpha 7 deficient fibroblasts

Loss of heterozygosity (LOH), malignancy grade and clonality in microdissected prostate cancer

The aim of the present study was to find out whether increasing malignancy of prostate carcinoma correlates with an overall increase of loss of heterozygosity (LOH), and whether LOH typing of microdissected tumour areas can help to distinguish between multifocal or clonal tumour development. In 47 carcinomas analysed at 25 chromosomal loci, the overall LOH rate was found to be significantly lower in grade 1 areas (2.2%) compared with grade 2 (9.4%) and grade 3 areas (8.3%, P = 0.007). A similar tendency was found for the mean fractional allele loss (FAL, 0.043 for grade 1, 0.2 for grade 2 and 0.23 for grade 3, P = 0.0004). Of 20 tumours (65%) with LOH in several microdissected areas, 13 had identical losses at 1–4 loci within two or three areas, suggesting clonal development of these areas. Markers near RB, DCC, BBC1, TP53 and at D13S325 (13q21–22) showed higher loss rates in grades 2 and 3 (between 25% and 44.4%) compared with grade 1 (0–6.6%). Tumour-suppressor genes (TSGs) near these loci might, thus, be important for tumour progression. TP53 mutations were detected in 27%, but BBC1 mutations in only 7%, of samples with LOH. Evaluation of all 25 loci in every tumour made evident that each prostate cancer has its own pattern of allelic losses. © 1999 Cancer Research Campaig

Clinical relevance of genetic instability in prostatic cells obtained by prostatic massage in early prostate cancer

We investigated whether genetic lesions such as loss of heterozygosity (LOH) are detected in prostatic cells obtained by prostatic massage during early diagnosis of prostate cancer (CaP) and discussed their clinical relevance. Blood and first urine voided after prostatic massage were collected in 99 patients with total prostate-specific antigen (PSA) between 4 and 10 ng ml−1, prior to prostate biopsies. Presence of prostatic cells was confirmed by quantitative RT–PCR analysis of PSA mRNA. Genomic DNA was analysed for LOH on six chromosomal regions. One or more allelic deletions were found in prostatic fluid from 57 patients analysed, of whom 33 (58%) had CaP. Sensitivity and specificity of LOH detection and PSA free to total ratio <15% for positive biopsy were respectively 86.7 and 44% (P=0.002) for LOH, and 55 and 74% (P=0.006) for PSA ratio <15%. Analysis of LOH obtained from prostatic tumours revealed similar patterns compared to prostatic fluid cells in 86% of cases, confirming its accuracy. The presence of LOH of urinary prostatic cells obtained after prostatic massage is significantly associated with CaP on biopsy and may potentially help to identify a set of patients who are candidates for further prostate biopsies

Importin α7 Is Essential for Zygotic Genome Activation and Early Mouse Development

Importin α is involved in the nuclear import of proteins. It also contributes to spindle assembly and nuclear membrane formation, however, the underlying mechanisms are poorly understood. Here, we studied the function of importin α7 by gene targeting in mice and show that it is essential for early embryonic development. Embryos lacking importin α7 display a reduced ability for the first cleavage and arrest completely at the two-cell stage. We show that the zygotic genome activation is severely disturbed in these embryos. Our findings indicate that importin α7 is a new member of the small group of maternal effect genes