2 research outputs found
Maintenance N-acetyl cysteine treatment for bipolar disorder : a double-blind randomised placebo controlled trial
Background N-acetyl cysteine (NAC) is a glutathione precursor that has been shown to have antidepressant efficacy in a placebo-controlled trial. The current study aimed to investigate the maintenance effects of NAC following eight weeks of open-label treatment for bipolar disorder.Method The efficacy of a double blind randomized placebo controlled trial of 2 g/day NAC as adjunct maintenance treatment for bipolar disorder was examined. Participants (n = 149) had a Montgomery Asberg Depression Rating Score of [greater than or equal to]12 at trial entry and, after eight weeks of open-label NAC treatment, were randomized to adjunctive NAC or placebo, in addition to treatment as usual. Participants (primarily outpatients) were recruited through public and private services and through newspaper advertisements. Time to intervention for a mood episode was the primary endpoint of the study, and changes in mood symptoms, functionality and quality of life measures were secondary outcomes.Results There was a substantial decrease in symptoms during the eight-week open-label NAC treatment phase. During the subsequent double-blind phase, there was minimal further change in outcome measures with scores remaining low. Consequently, from this low plateau, between-group differences did not emerge on recurrence, clinical functioning or quality of life measures.Conclusions There were no significant between-group differences in recurrence or symptomatic outcomes during the maintenance phase of the trial; however, these findings may be confounded by limitations. Trial Registration The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12607000074493)
High-spin structure of the neutron-rich Rh isotopes: the role of triaxiality
The Rh nuclei have been produced as fission fragments following the fusion reaction
Si + Yb at 145 MeV bombarding energy and studied with the Eurogam2 array. In both
nuclei three new rotational bands with the odd proton occupying the g,
p and (g/d) sub-shells have been observed. In Rh, two other
bands involving strong M1 transitions have been identified at excitation energy larger than 2 MeV.
They can be interpreted in terms of three quasiparticle excitations. In addition new structures
consisting of four transitions, built on states
located at low excitation energy (680 keV in Rh and 642 keV in Rh), point out the
importance of triaxial deformation in these two isotopes