1,142 research outputs found
A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes
SummaryObjectiveRecent studies revealed a close connection between adipose tissue, adipokines and articular degenerative inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). The goal of this work was to investigate the activity of adiponectin in human and murine chondrocytes and to study its functional role in the modulation of nitric oxide synthase type II (NOS2). For completeness, interleukin (IL)-6, IL-1ÎČ, matrix metalloproteinase (MMP)-2, MMP-3, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-1, prostaglandin E2 (PGE2), leukotriene B4 (LTB4), tumor necrosis factor alpha (TNF)-α and monocyte chemoattractant protein-1 (MCP-1) accumulation have been evaluated in adiponectin-stimulated chondrocytes cell culture supernatants.MethodsMurine ATDC5 cell line, C28/I2, C20A4, TC28a2 human immortalized chondrocytes, and human cultured chondrocytes were used. Nitrite accumulation was determined by Griess reaction. Adiponectin receptors (AdipoRs) expression was evaluated by immunofluorescence microscopy and confirmed by reverse transcriptase-polymerase chain reaction. NOS2 expression was evaluated by Western blot analysis whereas cytokines, prostanoids and metalloproteinases production was evaluated by specific enzyme-linked immunosorbent assays.ResultsHuman and murine chondrocytes express functional AdipoRs. Adiponectin induces NOS2. This effect is inhibited by aminoguanidine, dexamethasone and by a selective inhibitor of phosphatidylinositol 3-kinase. In addition, adiponectin is able to increase IL-6, MMP-3, MMP-9 and MCP-1 by murine cultured chondrocytes whereas it was unable to modulate TNF-α, IL-1ÎČ, MMP-2, TIMP-1, PGE2 and LTB4 release.ConclusionsThese results bind more closely the interactions between fat-derived adipokines and articular inflammatory diseases, and suggest that adiponectin is a novel key element in the maintenance of cartilage homeostasis which might be considered as a potential therapeutical target in joint degenerative diseases
A geometric bound on F-term inflation
We discuss a general bound on the possibility to realise inflation in any
minimal supergravity with F-terms. The derivation crucially depends on the
sGoldstini, the scalar field directions that are singled out by spontaneous
supersymmetry breaking. The resulting bound involves both slow-roll parameters
and the geometry of the K\"ahler manifold of the chiral scalars. We analyse the
inflationary implications of this bound, and in particular discuss to what
extent the requirements of single field and slow-roll can both be met in F-term
inflation.Comment: 14 pages, improved analysis, references added, matches published
versio
Exact Superpotentials, Theories with Flavor and Confining Vacua
In this paper we study some interesting properties of the effective
superpotential of N=1 supersymmetric gauge theories with fundamental matter,
with the help of the Dijkgraaf--Vafa proposal connecting supersymmetric gauge
theories with matrix models.
We find that the effective superpotential for theories with N_f fundamental
flavors can be calculated in terms of quantities computed in the pure (N_f=0)
gauge theory. Using this property we compute in a remarkably simple way the
exact effective superpotential of N=1 supersymmetric theories with fundamental
matter and gauge group SU(N_c), at the point in the moduli space where a
maximal number of monopoles become massless (confining vacua). We extend the
analysis to a generic point of the moduli space, and show how to compute the
effective superpotential in this general case.Comment: 16 pages, no figure
Moduli stabilization with positive vacuum energy
We study the effect of anomalous U(1) gauge groups in string theory
compactification with fluxes. We find that, in a gauge invariant formulation,
consistent AdS vacua appear breaking spontaneously supergravity. Non vanishing
D-terms from the anomalous symmetry act as an uplifting potential and could
allow for de Sitter vacua. However, we show that in this case the gravitino is
generically (but not always) much heavier than the electroweak scale. We show
that alternative uplifting scheme based on corrections to the Kahler potential
can be compatible with a gravitino mass in the TeV range.Comment: 20 pages, 1 figur
Moduli stabilization with Fayet-Iliopoulos uplift
In the recent years, phenomenological models of moduli stabilization were
proposed, where the dynamics of the stabilization is essentially
supersymmetric, whereas an O'Rafearthaigh supersymmetry breaking sector is
responsible for the "uplift" of the cosmological constant to zero. We
investigate the case where the uplift is provided by a Fayet-Iliopoulos sector.
We find that in this case the modulus contribution to supersymmetry breaking is
larger than in the previous models. A first consequence of this class of
constructions is for gauginos, which are heavier compared to previous models.
In some of our explicit examples, due to a non-standard gauge-mediation type
negative contribution to scalars masses, the whole superpartner spectrum can be
efficiently compressed at low-energy. This provides an original phenomenology
testable at the LHC, in particular sleptons are generically heavier than the
squarks.Comment: 29 pages, 2 figure
Metastable de Sitter vacua in N=2 to N=1 truncated supergravity
We study the possibility of achieving metastable de Sitter vacua in general
N=2 to N=1 truncated supergravities without vector multiplets, and compare with
the situations arising in N=2 theories with only hypermultiplets and N=1
theories with only chiral multiplets. In N=2 theories based on a quaternionic
manifold and a graviphoton gauging, de Sitter vacua are necessarily unstable,
as a result of the peculiar properties of the geometry. In N=1 theories based
on a Kahler manifold and a superpotential, de Sitter vacua can instead be
metastable provided the geometry satisfies some constraint and the
superpotential can be freely adjusted. In N=2 to N=1 truncations, the crucial
requirement is then that the tachyon of the mother theory be projected out from
the daughter theory, so that the original unstable vacuum is projected to a
metastable vacuum. We study the circumstances under which this may happen and
derive general constraints for metastability on the geometry and the gauging.
We then study in full detail the simplest case of quaternionic manifolds of
dimension four with at least one isometry, for which there exists a general
parametrization, and study two types of truncations defining Kahler
submanifolds of dimension two. As an application, we finally discuss the case
of the universal hypermultiplet of N=2 superstrings and its truncations to the
dilaton chiral multiplet of N=1 superstrings. We argue that de Sitter vacua in
such theories are necessarily unstable in weakly coupled situations, while they
can in principle be metastable in strongly coupled regimes.Comment: 40 pages, no figure
Effects of heavy modes on vacuum stability in supersymmetric theories
We study the effects induced by heavy fields on the masses of light fields in
supersymmetric theories, under the assumption that the heavy mass scale is much
higher than the supersymmetry breaking scale. We show that the square-masses of
light scalar fields can get two different types of significant corrections when
a heavy multiplet is integrated out. The first is an indirect level-repulsion
effect, which may arise from heavy chiral multiplets and is always negative.
The second is a direct coupling contribution, which may arise from heavy vector
multiplets and can have any sign. We then apply these results to the sGoldstino
mass and study the implications for the vacuum metastability condition. We find
that the correction from heavy chiral multiplets is always negative and tends
to compromise vacuum metastability, whereas the contribution from heavy vector
multiplets is always positive and tends on the contrary to reinforce it. These
two effects are controlled respectively by Yukawa couplings and gauge charges,
which mix one heavy and two light fields respectively in the superpotential and
the Kahler potential. Finally we also comment on similar effects induced in
soft scalar masses when the heavy multiplets couple both to the visible and the
hidden sector.Comment: LaTex, 24 pages, no figures; v2 some comments and references adde
Metastable supergravity vacua with F and D supersymmetry breaking
We study the conditions under which a generic supergravity model involving
chiral and vector multiplets can admit viable metastable vacua with
spontaneously broken supersymmetry and realistic cosmological constant. To do
so, we impose that on the vacuum the scalar potential and all its first
derivatives vanish, and derive a necessary condition for the matrix of its
second derivatives to be positive definite. We study then the constraints set
by the combination of the flatness condition needed for the tuning of the
cosmological constant and the stability condition that is necessary to avoid
unstable modes. We find that the existence of such a viable vacuum implies a
condition involving the curvature tensor for the scalar geometry and the charge
and mass matrices for the vector fields. Moreover, for given curvature, charges
and masses satisfying this constraint, the vector of F and D auxiliary fields
defining the Goldstino direction is constrained to lie within a certain domain.
The effect of vector multiplets relative to chiral multiplets is maximal when
the masses of the vector fields are comparable to the gravitino mass. When the
masses are instead much larger or much smaller than the gravitino mass, the
effect becomes small and translates into a correction to the effective
curvature. We finally apply our results to some simple classes of examples, to
illustrate their relevance.Comment: 40 pages; v2 some clarifications added in the introduction; v3 some
typos correcte
Warping and F-term uplifting
We analyse the effective supergravity model of a warped compactification with
matter on D3 and D7-branes. We find that the main effect of the warp factor is
to modify the F-terms while leaving the D-terms invariant. Hence warped models
with moduli stabilisation and a small positive cosmological constant resulting
from a large warping can only be achieved with an almost vanishing D-term and a
F-term uplifting. By studying string-motivated examples with gaugino
condensation on magnetised D7-branes, we find that even with a vanishing
D-term, it is difficult to achieve a Minkowski minimum for reasonable parameter
choices. When coupled to an ISS sector the AdS vacua is uplifted, resulting in
a small gravitino mass for a warp factor of order 10^-5.Comment: 24 pages, v3: typos, minor clarifications adde
Improved matrix-model calculation of the N=2 prepotential
We present a matrix-model expression for the sum of instanton contributions
to the prepotential of an N=2 supersymmetric U(N) gauge theory, with matter in
various representations. This expression is derived by combining the
renormalization-group approach to the gauge theory prepotential with
matrix-model methods. This result can be evaluated order-by-order in
matrix-model perturbation theory to obtain the instanton corrections to the
prepotential. We also show, using this expression, that the one-instanton
prepotential assumes a universal form.Comment: 20 pages, LaTeX, 2 figure
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