Pull-out strength of axially loaded steel rods bonded in glulam parallel to the grain

Bonded-in steel rods are very efficient in withstanding high forces applied to timber members. Investigations of bonded-in rods started in the late eighties of the last century and several design models were published since. By comparing these approaches on base of an extensive literature review a certain degree of discrepancy and partly even contradiction can be found. The paper describes a test program which aimed to study the influence of timber density and of geometric parameters on the pull-out strength of single axially loaded steel rods. Following the GSA®-procedure, which is a well established glued-in rods joint in Switzerland, rods with metric thread were bonded in glulam made of Norway spruce lamellas using an epoxy-type adhesive. The tests showed that the influence of the timber density can be quantified by a power function of ρ with an exponent of 0.6. The parameters length of the glued zone ℓ and diameter of the hole d H can be summarized in the slenderness ratio λ = ℓ/d H, which itself is related to the mean shear strength in the anchoring zone by an exponent of approximately −1/3. In order to prevent the specimens from premature splitting, distances between the axis of the rod and the edge of the specimen of 2.3 times the diameter of the rod have been use

Pull-out strength of axially loaded steel rods bonded in glulam perpendicular to the grain

A total of 86 pull-out strength tests on glued-in steel rods with metric threads M12, M16 and M20 are reported in this paper. The rods were bonded in glulam made of Norway spruce lamellas perpendicular to the grain by means of an epoxy-type adhesive using the GSA®-system. The slenderness ratios of the rods λ calculated from the anchoring lengths ℓ with respect to the diameter of the drill hole d h (λ=ℓ/d h) varied between 7.5 and 12.5. Registered failure loads were considerably higher than design values derived from different existing approaches. The pull-out strength was found to be almost directly proportional to the surface area of the bond line. Based on this an approach to estimate the pull-out strength is suggested. Dependence between pull-out strength and anchoring length ℓ as well as slenderness ratio λ exists, whereas such dependence for the diameter of the rod was not found. The pull-out strength is influenced by the wood density. Compared to rods bonded in parallel to the grain, pull-out strength of rods with same diameter and anchoring length set perpendicular to the grain are 20-50% highe

A hidden side of the COVID-19 pandemic in children: the double burden of undernutrition and overnutrition.

The COVID-19 pandemic has deteriorated key determinants of health and caused major upheavals around the world. Children, although less directly affected by the virus, are paying a heavy price through the indirect effects of the crisis, including poor diet, mental health impact, social isolation, addiction to screens and lack of schooling and health care, particularly among vulnerable groups. This paper is aimed at discussing the potential impact of this pandemic on children's nutrition and lifestyle. Preliminary data from the literature and from our survey show significant disruptions in nutrition and lifestyle habits of children. While undernutrition is expected to worsen in poor countries, obesity rates could increase in middle- and high-income countries especially among precarious groups widening the gap in health and social inequalities.The real impact of the COVID-19 pandemic on children extends well beyond that of a viral infection. This crisis has public health implications that could have life-long consequences on children. It requires effective and targeted measures mainly for vulnerable children and households to guarantee children's basic rights for optimal nutrition, health and development

The Influence of Minimalist Footwear on Knee and Ankle Load during Depth Jumping

Plyometric training is used by athletes to promote strength and explosive power. However plyometric activities such as depth jumping are associated with a high incidence of injuries. This study examined the influence of minimalist and conventional footwear on the loads experienced by the patellofemoral joint and Achilles tendon. Patellofemoral and Achilles tendon forces were obtained from ten male participants using an eight camera 3D motion capture system and force platform data as they completed depth jumps in both footwear conditions. Differences between footwear were calculated using paired t-tests. The results show that the minimalist footwear were associated with significantly lower patellofemoral contact force/ pressure and also knee abduction moment. It is therefore recommended based on these observations that those who are susceptible to knee pain should consider minimalist footwear when performing plyometric training

Managing childhood fever and pain – the comfort loop

Parents can transmit their anxiety to their child, and just as children can pick up on parental anxiety, they can also respond to a parent's ability to stay calm in stressful situations. Therefore, when treating children, it is important to address parental anxiety and to improve their understanding of their child's ailment. Parental understanding and management of both pain and fever – common occurrences in childhood – is of utmost importance, not just in terms of children's health and welfare, but also in terms of reducing the economic burden of unnecessary visits to paediatric emergency departments. Allaying parental anxiety reduces the child's anxiety and creates a positive feedback loop, which ultimately affects both the child and parent

Using death to one's advantage: HIV modulation of apoptosis

Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4+ T lymphocytes. This progressive disappearance of T cells leads to a lack of immune control of HIV replication and to the development of immune deficiency resulting in the increased occurrence of opportunistic infections associated with acquired immune deficiency syndrome (AIDS). The HIV-induced, premature destruction of lymphocytes is associated with the continuous production of HIV viral proteins that modulate apoptotic pathways. The viral proteins, such as Tat, Env, and Nef, are associated with chronic immune activation and the continuous induction of apoptotic factors. Viral protein expression predisposes lymphocytes, particularly CD4+ T cells, CD8+ T cells, and antigen-presenting cells, to evolve into effectors of apoptosis and as a result, to lead to the destruction of healthy, non-infected T cells. Tat and Nef, along with Vpu, can also protect HIV-infected cells from apoptosis by increasing anti-apoptotic proteins and down- regulating cell surface receptors recognized by immune system cells. This review will discuss the validity of the apoptosis hypothesis in HIV disease and the potential mechanism(s) that HIV proteins perform in the progressive T cell depletion observed in AIDS pathogenesis. Originally published Leukemia, Vol. 15, No. 3, Mar 200

Manipulation of Costimulatory Molecules by Intracellular Pathogens: Veni, Vidi, Vici!!

Some of the most successful pathogens of human, such as Mycobacterium tuberculosis (Mtb), HIV, and Leishmania donovani not only establish chronic infections but also remain a grave global threat. These pathogens have developed innovative strategies to evade immune responses such as antigenic shift and drift, interference with antigen processing/presentation, subversion of phagocytosis, induction of immune regulatory pathways, and manipulation of the costimulatory molecules. Costimulatory molecules expressed on the surface of various cells play a decisive role in the initiation and sustenance of immunity. Exploitation of the “code of conduct” of costimulation pathways provides evolutionary incentive to the pathogens and thereby abates the functioning of the immune system. Here we review how Mtb, HIV, Leishmania sp., and other pathogens manipulate costimulatory molecules to establish chronic infection. Impairment by pathogens in the signaling events delivered by costimulatory molecules may be responsible for defective T-cell responses; consequently organisms grow unhindered in the host cells. This review summarizes the convergent devices that pathogens employ to tune and tame the immune system using costimulatory molecules. Studying host-pathogen interaction in context with costimulatory signals may unveil the molecular mechanism that will help in understanding the survival/death of the pathogens. We emphasize that the very same pathways can potentially be exploited to develop immunotherapeutic strategies to eliminate intracellular pathogens

Genetic Assessment of Boardman River Fish Populations Before Dam Removal

The genetic assessment of fish populations in the Boardman River, MI presented here incorporated two unique approaches to address a variety of questions about population structure and species richness in this system. These two research projects are presented as two distinct chapters in this thesis, and each respective abstract is given below. Fragmentation of river systems by dams can have a substantial genetic impact on fish populations. However, genetic structure can exist naturally at small scales through various processes such as isolation by adaptation (IBA) and spawning site fidelity, even in the absence of barriers. We sampled individuals from five native fish species with varying life histories above and below a dam in the lower Boardman River, Michigan, USA, and used RADseq to test whether genetic structure was influenced by the dam or other processes. Species assessed were white sucker Catostomus commerson, yellow perch Perca flavescens, walleye Sander vitreus, smallmouth bass Micropterus dolomieu, and rock bass Ambloplites rupestris. We detected significant differentiation within each species, but this structure did not appear to be a result of fragmentation by the dam. Population groupings were not consistent with our original “above dam” and “below dam” sampled populations, but instead aligned with a Great Lakes (GL) group from Lake Michigan and a Boardman River (BR) group that appear to mix below the dam. We hypothesize that these groups formed prior to dam construction through IBA in these different habitats and further maintained divergence through spawning site fidelity. Additionally, GL fish for most species were significantly smaller in length than BR fish, suggesting a potential ontogenetic habitat shift of young GL fish into the lower river for feeding and/or refuge. Without our genetic assessment, the existence of these cryptic ecotypes likely would have continued undetected. Our study illuminates the importance of tributary habitats for GL fish and has major implications for the management of fish populations in the Great Lakes and beyond. Finally, our approach of combining genetic data, ecological data, and simulations to assess connectivity and identify cryptic diversity has far reaching applicability for understanding the potential genetic impacts of fragmentation in other systems. Understanding biodiversity in aquatic systems is critical to ecological research and conservation efforts, but accurately measuring species richness using traditional methods can be challenging. Environmental DNA (eDNA) metabarcoding, which uses high-throughput sequencing and universal primers to amplify DNA from multiple species present in an environmental sample, has shown great promise for augmenting results from traditional sampling to characterize fish communities in aquatic systems. Few studies, however, have compared exhaustive traditional sampling with eDNA metabarcoding of corresponding water samples at a small spatial scale. We intensively sampled Boardman Lake (137 ha) in Michigan, USA from May to June in 2019 using gill and fyke nets and paired each net set with lake water samples collected in triplicate. We analyzed water samples using eDNA metabarcoding with 12S and 16S fish-specific primers and compared estimates of fish diversity among methods. We captured a total of 12 fish species in our traditional gear and detected 40 taxa in the eDNA water samples, which included all the species observed in nets. The 12S and 16S assays detected a comparable number of taxa, but taxonomic resolution varied between the two genes. In our traditional gear, there was a clear difference in the species selectivity between the two net types, and there were several species commonly detected in the eDNA samples that were not captured in nets. Finally, we detected spatial heterogeneity in fish community composition across relatively small scales in Boardman Lake with eDNA metabarcoding, but not with traditional sampling. Our results demonstrated that eDNA metabarcoding was substantially more efficient than traditional gear for estimating community composition, highlighting the utility of eDNA metabarcoding for assessing species diversity and informing management and conservation

Pull-out strength of axially loaded steel rods bonded in glulam perpendicular to the grain

ISSN:1359-5997ISSN:0025-5432ISSN:1871-687