A voice operated musical instrument.

Many mathematical formulas and algorithms exist to identify pitches formed by human voices, and this has continued to be popular in the fields of music and signal pro-cessing. Other systems and research perform real time pitch identification implemented by using PCs with system clocks faster than 400MHz. This thesis explores developing an embedded RPTI system using the average magnitude difference function (AMDF), which will also use MIDI commands to control a synthesizer to track the pitch in near real time. The AMDF algorithm was simulated and its performance analyzed in MATLAB with pre-recorded sound files from a PC. Errors inherent to the AMDF and the hardware constraints led to noticeable pitch errors. The MATLAB code was optimized and its performance verified for the Motorola 68000 assembly language. This stage of development led to realization that the original design would have to change for the processing time required for the AMDF implementation. Hardware was constructed to support an 8MHz Motorola 68000, analog input, and MIDI communications. The various modules were constructed using Vectorbord© prototyping board with soldered tracks, wires and sockets. Modules were tested individually and as a whole unit. A design flaw was noticed with the final design, which caused the unit to fail during program execution while operating in a stand-alone mode. This design is a proof of concept for a product that can be improved upon with newer components, more advanced algorithms and hardware construction, and a more aesthetically pleasing package. Ultimately, hardware limitations imposed by the available equipment in addition to a hidden design flaw contributed to the failure of this stand-alone prototype

Effect of humidity on transonic flow

An experimental investigation of the effects of humidity-induced condensation on shock/boundary-layer interaction has been conducted in a transonic wind-tunnel test. The test geometry considered was a wall-mounted bump model inserted in the test section of the wind tunnel. The formation of a λ-shape condensation shock wave was shown from schlieren visualization and resulted in a forward movement of the shock wave, reduced shock wave strength, and reduced separation. Empirical correlations of the shock wave strength and humidity/dew point temperature were established. For humidity levels below 0.15 or a dew point temperature of 268 K, the effect of humidity was negligible. The unsteady pressure measurements showed that if a condensation shock wave formed and interacted with a main shock wave, the flow becomes unsteady with periodic flow oscillations occurring at 720 Hz

Space station impact experiments

Four processes serve to illustrate potential areas of study and their implications for general problems in planetary science. First, accretional processes reflect the success of collisional aggregation over collisional destruction during the early history of the solar system. Second, both catastrophic and less severe effects of impacts on planetary bodies survivng from the time of the early solar system may be expressed by asteroid/planetary spin rates, spin orientations, asteroid size distributions, and perhaps the origin of the Moon. Third, the surfaces of planetary bodies directly record the effects of impacts in the form of craters; these records have wide-ranging implications. Fourth, regoliths evolution of asteroidal surfaces is a consequence of cumulative impacts, but the absence of a significant gravity term may profoundly affect the retention of shocked fractions and agglutinate build-up, thereby biasing the correct interpretations of spectral reflectance data. An impact facility on the Space Station would provide the controlled conditions necessary to explore such processes either through direct simulation of conditions or indirect simulation of certain parameters

Planetary science

The following types of experiments for a proposed Space Station Microgravity Particle Research Facility are described: (1) low velocity collisions between fragile particles; (2) low velocity collisions of ice particles; (3) plasma-dust interaction; and (4) aggregation of finely-comminuted geological materials. The required capabilities and desired hardware for the facility are detailed

From solid solution to cluster formation of Fe and Cr in α\alpha-Zr

To understand the mechanisms by which Fe and Cr additions increase the corrosion rate of irradiated Zr alloys, a combination of experimental (atom probe tomography, x-ray diffraction and thermoelectric power measurements) and modelling (density functional theory) techniques are employed to investigate the non-equilibrium solubility and clustering of Fe and Cr in binary Zr alloys. Cr occupies both interstitial and substitutional sites in the {\alpha}-Zr lattice, Fe favours interstitial sites, and a low-symmetry site that was not previously modelled is found to be the most favourable for Fe. Lattice expansion as a function of alloying concentration (in the dilute regime) is strongly anisotropic for Fe additions, expanding the $c$-axis while contracting the $a$-axis. Defect clusters are observed at higher solution concentrations, which induce a smaller amount of lattice strain compared to the dilute defects. In the presence of a Zr vacancy, all two-atom clusters are more soluble than individual point defects and as many as four Fe or three Cr atoms could be accommodated in a single Zr vacancy. The Zr vacancy is critical for the increased solubility of defect clusters, the implications for irradiation induced microstructure changes in Zr alloys are discussed.Comment: 15 pages including figure, 9 figures, 2 tables. Submitted for publication in Acta Mater, Journal of Nuclear Materials (2015

Research on lunar Mare emplacement and impact cratering experiments

A model was derived enabling the interpretation of lunar styles of volcanism through the analysis of various surface features. The model was applied to several areas on the Moon, including the Orientale Basin, the Smythii Basin, the Herigonious region, and several highland areas. Concurrent with the application of the model, several topical studies of various aspects of lunar volcanism were completed. A series of impact crater experiments was conducted at NASA Ames in order to determine the effect that viscous targets would have on cratering mechanics and morphology for application in studies of Martian ejecta flow craters. The results of the experiments led to a model that can account for the formation of multiple flow lobes and the general morphology of some aspects of Martian craters

askMEDLINE: a free-text, natural language query tool for MEDLINE/PubMed

BACKGROUND: Plain language search tools for MEDLINE/PubMed are few. We wanted to develop a search tool that would allow anyone using a free-text, natural language query and without knowing specialized vocabularies that an expert searcher might use, to find relevant citations in MEDLINE/PubMed. This tool would translate a question into an efficient search. RESULTS: The accuracy and relevance of retrieved citations were compared to references cited in BMJ POEMs and CATs (critically appraised topics) questions from the University of Michigan Department of Pediatrics. askMEDLINE correctly matched the cited references 75.8% in POEMs and 89.2 % in CATs questions on first pass. When articles that were deemed to be relevant to the clinical questions were included, the overall efficiency in retrieving journal articles was 96.8% (POEMs) and 96.3% (CATs.) CONCLUSION: askMEDLINE might be a useful search tool for clinicians, researchers, and other information seekers interested in finding current evidence in MEDLINE/PubMed. The text-only format could be convenient for users with wireless handheld devices and those with low-bandwidth connections in remote locations

Consequences of asteroid fragmentation during impact hazard mitigation

The consequences of the fragmentation of an Earth-threatening asteroid due to an attempted deflection are examined in this paper. The minimum required energy for a successful impulsive deflection of a threatening object is computed and compared to the energy required to break up a small size asteroid. The results show that the fragmentation of an asteroid that underwent an impulsive deflection, such as a kinetic impact or a nuclear explosion, is a very plausible event.Astatistical model is used to approximate the number and size of the fragments as well as the distribution of velocities at the instant after the deflection attempt takes place. This distribution of velocities is a function of the energy provided by the deflection attempt, whereas the number and size of the asteroidal fragments is a function of the size of the largest fragment. The model also takes into account the gravity forces that could lead to a reaggregation of the asteroid after fragmentation. The probability distribution of the pieces after the deflection is then propagated forward in time until the encounter with Earth. A probability damage factor (i.e., expected damage caused by a given size fragment multiplied by its impact probability) is then computed and analyzed for different plausible scenarios, characterized by different levels of deflection energies and lead times

Does glucose-dependent insulinotropic polypeptide receptor blockade as well as agonism have a role to play in management of obesity and diabetes?

Recent approval of the dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, tirzepatide, for the management of type 2 diabetes mellitus (T2DM) has reinvigorated interest in exploitation of GIP receptor (GIPR) pathways as a means of metabolic disease management. However, debate has long surrounded the use of the GIPR as a therapeutic target and whether agonism or antagonism is of most benefit in management of obesity/diabetes. This controversy appears to be partly resolved by the success of tirzepatide. However, emerging studies indicate that prolonged GIPR agonism may desensitise the GIPR to essentially induce receptor antagonism, with this phenomenon suggested to be more pronounced in the human than rodent setting. Thus, deliberation continues to rage in relation to benefits of GIPR agonism vs. antagonism. That said, as with GIPR agonism, it is clear that the metabolic advantages of sustained GIPR antagonism in obesity and obesity-driven forms of diabetes can be enhanced by concurrent GLP-1 receptor (GLP-1R) activation. This narrative review discusses various approaches of pharmacological GIPR antagonism including small molecule, peptide, monoclonal antibody and peptide-antibody conjugates, indicating stage of development and significance to the field. Taken together, there is little doubt that interesting times lie ahead for GIPR agonism and antagonism, either alone or when combined with GLP-1R agonists, as a therapeutic intervention for the management of obesity and associated metabolic disease

Mercury

Prior to the flight of the Mariner 10 spacecraft, Mercury was the least investigated and most poorly known terrestrial planet (Kuiper 1970, Devine 1972). Observational difficulties caused by its proximity to the Sun as viewed from Earth caused the planet to remain a small, vague disk exhibiting little surface contrast or details, an object for which only three major facts were known: 1. its bulk density is similar to that of Venus and Earth, much greater than that of Mars and the Moon; 2. its surface reflects electromagnetic radiation at all wavelengths in the same manner as the Moon (taking into account differences in their solar distances); and 3. its rotation period is in 2/3 resonance with its orbital period. Images obtained during the flyby by Mariner 10 on 29 March 1974 (and the two subsequent flybys on 21 September 1974 and 16 March 1975) revealed Mercury's surface in detail equivalent to that available for the Moon during the early 1960's from Earth-based telescopic views. Additionally, however, information was obtained on the planet's mass and size, atmospheric composition and density, charged-particle environment, and infrared thermal radiation from the surface, and most significantly of all, the existence of a planetary magnetic field that is probably intrinsic to Mercury was established. In the following, this new information is summarized together with results from theoretical studies and ground-based observations. In the quantum jumps of knowledge that have been characteristic of "space-age" exploration, the previously obscure body of Mercury has suddenly come into sharp focus. It is very likely a differentiated body, probably contains a large Earth-like iron-rich core, and displays a surface remarkably similar to that of the Moon, which suggests a similar evolutionary history