4,889 research outputs found
Studies on the Kinetics of very Rapid Cooling in Different Quenching Liquids- Application to Some Alloys of Iron, Nickel and Carbon
0NE can set the problem of quenching metals and alloys
in the following manner.
Let us consider a structural transformation arising in the metal or alloy within a certain interval of temperature 01, 02.
Let its suppose that this transformation, without induction period, has an initial speed characterized by finite values at all the temperatures within the interval 01, 02, and by negligible value, at the boundaries 01
and 02 of this interval.
This speed of transformation can be measured for all the temperatures within the interval 01, O2 by recording, against time, the variations of a physical property of
the sample in direct relation with its structure.With the well-known isothermal thermodilatometer of Prof. Cheve-narci, this physical property is the length of a cylin-drical wire of some millimetres in diameter and 50
millimetres in length
Characterization of the glass transition in vitreous silica by temperature scanning small-angle X-ray scattering
The temperature dependence of the x-ray scattering in the region below the
first sharp diffraction peak was measured for silica glasses with low and high
OH content (GE-124 and Corning 7980). Data were obtained upon scanning the
temperature at 10, 40 and 80 K/min between 400 K and 1820 K. The measurements
resolve, for the first time, the hysteresis between heating and cooling through
the glass transition for silica glass, and the data have a better signal to
noise ratio than previous light scattering and differential thermal analysis
data. For the glass with the higher hydroxyl concentration the glass transition
is broader and at a lower temperature. Fits of the data to the
Adam-Gibbs-Fulcher equation provide updated kinetic parameters for this very
strong glass. The temperature derivative of the observed X-ray scattering
matches that of light scattering to within 14%.Comment: EurophysicsLetters, in pres
Swinging of red blood cells under shear flow
We reveal that under moderate shear stress (of the order of 0.1 Pa) red blood
cells present an oscillation of their inclination (swinging) superimposed to
the long-observed steady tanktreading (TT) motion. A model based on a fluid
ellipsoid surrounded by a visco-elastic membrane initially unstrained (shape
memory) predicts all observed features of the motion: an increase of both
swinging amplitude and period (1/2 the TT period) upon decreasing the shear
stress, a shear stress-triggered transition towards a narrow shear stress-range
intermittent regime of successive swinging and tumbling, and a pure tumbling
motion at lower shear stress-values.Comment: 4 pages 5 figures submitted to Physical Review Letter
In situ measurements of density fluctuations and compressibility in silica glass as a function of temperature and thermal history
In this paper, small-angle X-ray scattering measurements are used to
determine the different compressibility contributions, as well as the
isothermal compressibility, in thermal equilibrium in silica glasses having
different thermal histories. Using two different methods of analysis, in the
supercooled liquid and in the glassy state, we obtain respectively the
temperature and fictive temperature dependences of the isotheraml
compressibility. The values obtained in the glass and supercooled liquid states
are very close to each other. They agree with previous determinations of the
literature. The compressibility in the glass state slightly decreases with
increasing fictive temperature. The relaxational part of the compressibility is
also calculated and compared to previous determinations. We discussed the small
differences between the different determinations
Discovery Prospects for a Supernova Signature of Biogenic Origin
Approximately 2.8 Myr before the present our planet was subjected to the
debris of a supernova explosion. The terrestrial proxy for this event was the
discovery of live atoms of 60Fe in a deep-sea ferromanganese crust. The
signature for this supernova event should also reside in magnetite Fe3O4
microfossils produced by magnetotactic bacteria extant at the time of the
Earth-supernova interaction, provided the bacteria preferentially uptake iron
from fine-grained iron oxides and ferric hydroxides. Using estimates for the
terrestrial supernova 60Fe flux, combined with our empirically derived
microfossil concentrations in a deep-sea drill core, we deduce a conservative
estimate of the ^{60}{Fe} fraction as 60Fe/Fe ~ 3.6 x 10^{-15}. This value sits
comfortably within the sensitivity limit of present accelerator mass
spectrometry capabilities. The implication is that a biogenic signature of this
cosmic event is detectable in the Earth's fossil record.Comment: As it appears in Icaru
Pattern Stability and Trijunction Motion in Eutectic Solidification
We demonstrate by both experiments and phase-field simulations that lamellar
eutectic growth can be stable for a wide range of spacings below the point of
minimum undercooling at low velocity, contrary to what is predicted by existing
stability analyses. This overstabilization can be explained by relaxing Cahn's
assumption that lamellae grow locally normal to the eutectic interface.Comment: 4 pages, 5 eps figure
Determination of an optimal response cut-off able to predict progression-free survival in patients with well-differentiated advanced pancreatic neuroendocrine tumours treated with sunitinib: an alternative to the current RECIST-defined response.
BACKGROUND: Sunitinib prolongs progression-free survival (PFS) in patients with advanced pancreatic neuroendocrine tumours (pNET). Response Evaluation Criteria in Solid Tumors (RECIST)-defined partial responses (PR; classically defined as ⩾30% size decrease from baseline) are infrequent.
METHODS: Individual data of pNET patients from the phase II [NCT00056693] and pivotal phase III [NCT00428597] trials of sunitinib were analysed in this investigator-initiated, post hoc study. The primary objective was to determine the optimal RECIST (v.1.0) response cut-off value to identify patients who were progression-free at 11 months (median PFS in phase III trial); and the most informative time-point (highest area under the curve (AUC) by receiver operating characteristic (ROC) analysis and logistic regression) for prediction of benefit (PFS) from sunitinib.
RESULTS: Data for 237 patients (85 placebo; 152 sunitinib (n=66.50 mg \u274-weeks on/2-weeks off\u27 schedule; n=86 \u2737.5 mg continuous daily dosing (CDD)\u27)) and 788 scans were analysed. The median PFS for sunitinib and placebo were 9.3 months (95% CI 7.6-12.2) and 5.4 months (95% CI 3.5-6.01), respectively (hazard ratio (HR) 0.43 (95% CI 0.29-0.62); P
CONCLUSIONS: A 10% reduction within marker lesions identifies pNET patients benefiting from sunitinib treatment with implications for maintenance of dose intensity and future trial design
Targeting cancer cell metabolism in pancreatic adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited, warranting an urgent need to explore innovative treatment strategies. Due to specific microenvironment constraints including an extensive desmoplastic stroma reaction, PDAC faces major metabolic challenges, principally hypoxia and nutrient deprivation. Their connection with oncogenic alterations such as KRAS mutations has brought metabolic reprogramming to the forefront of PDAC therapeutic research. The Warburg effect, glutamine addiction, and autophagy stand as the most important adaptive metabolic mechanisms of cancer cells themselves, however metabolic reprogramming is also an important feature of the tumor microenvironment, having a major impact on epigenetic reprogramming and tumor cell interactions with its complex stroma. We present a comprehensive overview of the main metabolic adaptations contributing to PDAC development and progression. A review of current and future therapies targeting this range of metabolic pathways is provided
Influence of thermal history on the structure and properties of silicate glasses
We studied a set of float glass samples prepared with different fictive
temperature by previous annealing around the glass transition temperature. We
compared the results to previous measurements on a series of amorphous silica
samples, also prepared with different fictive temperature. We showed that the
modifications on the structure at a local scale are very small, the changes of
physical properties are moderate but the changes on density fluctuations at a
nanometer scale are rather large: 12 and 20% in float glass and silica, for
relative changes of fictive temperature equal to 13 and 25% respectively. Local
order and mechanical properties of silica vary in the opposite way compared to
float glass (anomalous behavior) but the density fluctuations in both glasses
increase with temperature and fictive temperature
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