4,863 research outputs found
An experimental investigation of a fully cavitating two-dimensional flat plate hydrofoil near a free surface
An experimental program was conducted to investigate the characteristics of a fully cavitating two-dimensional flat plate hydrofoil in the presence of a free surface. The submergence of the hydrofoil was varied from the planing condition at the free surface to a depth corresponding to 2.16 model chords. Near the surface the cavities formed by venting to the atmosphere, but at the deeper submergences, they had to be artificially formed by supplying them with air.
The normal force, the moment about the leading edge, the center of pressure location, the cavity length, and the volumetric air flow rate into the cavity are presented as functions of angle of attack, cavitation number, Froude number, and proximity to the free surface
Information requirements for guidance and control systems
Control or guidance system performance dependency on information handling by subsystem
Finite top quark mass effects in NNLO Higgs boson production at LHC
We present next-to-next-to-leading order corrections to the inclusive
production of the Higgs bosons at the CERN Large Hadron Collider (LHC)
including finite top quark mass effects. Expanding our analytic results for the
partonic cross section around the soft limit we find agreement with a very
recent publication by Harlander and Ozeren \cite{Harlander:2009mq}.Comment: 15 page
The HST/ACS Grism Parallel Survey: II. First Results and a Catalog of Faint Emission-Line Galaxies at z < 1.6
We present the first results from the HST/ACS Grism Parallel Survey, a large
program obtaining deep, slitless ACS grism spectroscopy of high-latitude HST
parallel fields. We report on 11 high Galactic latitude fields here, each with
grism integration times >12 ks. We identify 601 compact emission line galaxies
at z 5 E-18 ergs/cm^2/s (3
sigma). We determine redshifts by cross correlation of the target spectra with
template spectra, followed by visual inspection. We measure star formation
rates from the observed [OII] 3727, [OIII] 5007 and Halpha line fluxes.
Follow-up observations with the Keck telescope of one of the survey fields
confirms our classification and redshifts with sigma(z)~0.02. This is one of
the deepest emission line surveys to date, covering a total area of 121
arcmin^2. The rough estimate of the co-moving number density of emission-line
galaxies in our survey at 0.3 < z < 1.3 is ~4.5 E-3 h^{-3}_70 Mpc^{-3}. We
reach deeper into the emission-line luminosity function than either the STIS or
NICMOS grism parallel surveys, finding an apparent space density of emission
line galaxies several times higher than those surveys. Because of the ACS high
spatial resolution, our survey is very sensitive to faint, compact galaxies
with strong emission lines and weak continua. The ACS grism survey provides the
co-moving star formation density at z < 1.6 at a high level of completeness.Comment: 20 pages, 12 figures, Accepted to the Astronomical Journal, Also
available at: http://www.astro.spbu.ru/staff/dio/ACS_G800L/ACS_G800L.htm
The design of an experiment to determine the limitations imposed on a multiple-aperture antenna system by propagation phenomena third quarterly report, 1 dec. 1964 - 28 feb. 1965
Antenna array experiment to determine propagation path limitations on multiple aperture radio antenna
Effective suppression of Dengue virus using a novel group-I intron that induces apoptotic cell death upon infection through conditional expression of the Bax C-terminal domain
Introduction:
Approximately 100 million confirmed infections and 20,000 deaths are caused by Dengue virus (DENV) outbreaks annually. Global warming and rapid dispersal have resulted in DENV epidemics in formally non-endemic regions. Currently no consistently effective preventive measures for DENV exist, prompting development of transgenic and paratransgenic vector control approaches. Production of transgenic mosquitoes refractory for virus infection and/or transmission is contingent upon defining antiviral genes that have low probability for allowing escape mutations, and are equally effective against multiple serotypes. Previously we demonstrated the effectiveness of an anti-viral group I intron targeting U143 of the DENV genome in mediating trans-splicing and expression of a marker gene with the capsid coding domain. In this report we examine the effectiveness of coupling expression of ΔN Bax to trans-splicing U143 intron activity as a means of suppressing DENV infection of mosquito cells.
Results:
Targeting the conserved DENV circularization sequence (CS) by U143 intron trans-splicing activity appends a 3’ exon RNA encoding ΔN Bax to the capsid coding region of the genomic RNA, resulting in a chimeric protein that induces premature cell death upon infection. TCID50-IFA analyses demonstrate an enhancement of DENV suppression for all DENV serotypes tested over the identical group I intron coupled with the non-apoptotic inducing firefly luciferase as the 3’ exon. These cumulative results confirm the increased effectiveness of this αDENV-U143-ΔN Bax group I intron as a sequence specific antiviral that should be useful for suppression of DENV in transgenic mosquitoes. Annexin V staining, caspase 3 assays, and DNA ladder observations confirm DCA-ΔN Bax fusion protein expression induces apoptotic cell death.
Conclusion:
This report confirms the relative effectiveness of an anti-DENV group I intron coupled to an apoptosis-inducing ΔN Bax 3’ exon that trans-splices conserved sequences of the 5’ CS region of all DENV serotypes and induces apoptotic cell death upon infection. Our results confirm coupling the targeted ribozyme capabilities of the group I intron with the generation of an apoptosis-inducing transcript increases the effectiveness of infection suppression, improving the prospects of this unique approach as a means of inducing transgenic refractoriness in mosquitoes for all serotypes of this important disease
On the effect of resonances in composite Higgs phenomenology
We consider a generic composite Higgs model based on the coset SO(5)/SO(4)
and study its phenomenology beyond the leading low-energy effective lagrangian
approximation. Our basic goal is to introduce in a controllable and simple way
the lowest-lying, possibly narrow, resonances that may exist is such models. We
do so by proposing a criterion that we call partial UV completion. We
characterize the simplest cases, corresponding respectively to a scalar in
either singlet or tensor representation of SO(4) and to vectors in the adjoint
of SO(4). We study the impact of these resonances on the signals associated to
high-energy vector boson scattering, pointing out for each resonance the
characteristic patterns of depletion and enhancement with respect to the
leading-order chiral lagrangian. En route we derive the O(p^4) general chiral
lagrangian and discuss its peculiar accidental and approximate symmetries.Comment: v3: a few typos corrected. Conclusions unchange
Validity of numerical trajectories in the synchronization transition of complex systems
We investigate the relationship between the loss of synchronization and the
onset of shadowing breakdown {\it via} unstable dimension variability in
complex systems. In the neighborhood of the critical transition to strongly
non-hyperbolic behavior, the system undergoes on-off intermittency with respect
to the synchronization state. There are potentially severe consequences of
these facts on the validity of the computer-generated trajectories obtained
from dynamical systems whose synchronization manifolds share the same
non-hyperbolic properties.Comment: 4 pages, 4 figure
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