639 research outputs found
Improving Skills When Working with Challenging Behaviors: Get âSneaky Smartâ
As we work to ensure that all children & youth are in a safe/secure environment where they feel special and can learn, it is humbling when we face challenging behaviors. There isnât a definitive âguidebookâ for educators and parents to turn to, thus making us hungry for more training in behavior management, especially proactive strategies. This presentation will help the participants to see that being âsneaky smartâ is all about changing adult behavior, being flexible & willing to truly problem solve, and being more skilled at ways to alter the environment & the positive supports that we can put into place. Evidenced-based strategies will be reviewed that the participants can begin to implement immediately with children that fall into all tiers. Through humor of the mistakes that we often make & by noting his colorful NC background, the presenter has compiled & will summarize interventions & strategies from both his experiences as a school psychologist and leader of the PBIS initiative in a large school district in SC, as well as those from many of the national leaders in PBIS. His âsneaky smartâ strategies are appropriate for most any classroom or home setting to increase compliance of both groups of students and individual ones. His review of methods for being proactive and how to intervene with an individual that is agitated and resistant have been used widely. A quick, easy and flexible way to document behavior will also be shared, especially for the classroom setting, along with some great resources for parents and educators that are available for pinpointing those behavioral skills that may be lacking
Long-Term Potentiation: One Kind or Many?
Do neurobiologists aim to discover natural kinds? I address this question in this chapter via a critical analysis of classification practices operative across the 43-year history of research on long-term potentiation (LTP). I argue that this 43-year history supports the idea that the structure of scientific practice surrounding LTP research has remained an obstacle to the discovery of natural kinds
Potentiality in Biology
We take the potentialities that are studied in the biological sciences (e.g., totipotency) to be an important subtype of biological dispositions. The goal of this paper is twofold: first, we want to provide a detailed understanding of what biological dispositions are. We claim that two features are essential for dispositions in biology: the importance of the manifestation process and the diversity of conditions that need to be satisfied for the disposition to be manifest. Second, we demonstrate that the concept of a disposition (or potentiality) is a very useful tool for the analysis of the explanatory practice in the biological sciences. On the one hand it allows an in-depth analysis of the nature and diversity of the conditions under which biological systems display specific behaviors. On the other hand the concept of a disposition may serve a unificatory role in the philosophy of the natural sciences since it captures not only the explanatory practice of biology, but of all natural sciences. Towards the end we will briefly come back to the notion of a potentiality in biology
Synthesis of silver nanoparticles using a modified Tollensâ method in conjunction with phytochemicals and assessment of their antimicrobial activity
Background: Silver nanoparticles (AgNPs) have attracted great attention due to their outstanding electrical, optical, magnetic, catalytic, and antimicrobial properties. However, there is a need for alternative production methods that use less toxic precursors and reduce their undesirable by-products. Phyto-extracts from the leaves of olive and rosemary plants can be used as reducing agents and (in conjunction with Tollensâ reagent) can even enhance AgNP antimicrobial activity.
Methods: Conditions for the proposed hybrid synthesis method were optimized for olive leaf extracts (OLEs) and rosemary leaf extracts (RLEs). The resultant AgNPs were characterized using UVâvisible spectroscopy, an environmental scanning electron microscope, and Dynamic Light Scattering analysis. An atomic absorption spectrophotometer was used to measure AgNP concentration. Fourier transform infrared spectroscopy (FTIR) was used to determine the specific functional groups responsible for the reduction of both silver nitrate and capping agents in the leaf extract. Additionally, the antimicrobial properties of the synthesized AgNPs were assessed against Gram-negative bacteria (Escherichia coli and Salmonella enterica) and Gram-positive bacteria (Staphylococcus aureus), by using both the KirbyâBauer and broth microdilution methods on MuellerâHinton (MH) agar plates.
Results and Discussion: A simple, feasible, and rapid method has been successfully developed for silver nanoparticle synthesis by reducing Tollensâ reagent using leaf extracts from olive and rosemary plants (widely available in Jordan). Scanning electron microscopy images showed that the method produces AgNPs with a spherical shape and average core sizes of 45 ± 2 and 38 ± 3 nm for OLE and RLE, respectively. A negative zeta potential (ζ) of â43.15 ± 3.65 mV for OLE-AgNPs and â33.65 ± 2.88mV for RLE-AgNPs proved the stability of silver nanoparticles. FTIR spectra for AgNPs and leaf extracts indicated that the compounds present in the leaf extracts play an important role in the coating/capping of synthesized nanoparticles. The manufactured AgNPs exhibited an antibacterial effect against Escherichia coli and Staphylococcus aureus with minimum inhibitory concentrations (MIC) of 9.38 and 4.69 ÎŒl/ml for OLE-AgNPs and RLE-AgNPs, respectively. The MIC for Salmonella enterica were 18.75 ÎŒl/ml for both OLE-AgNPs and RLE-AgNPs. Furthermore, our results indicated that the RLE-AgNPs exhibited a stronger antibacterial effect than OLE-AgNPs against different bacteria species. These results contribute to the body of knowledge on nanoparticle production using plant-mediated synthesis and performance. They also offer insights into the potential for scaling up this production process for commercial implementation
Reviews and perspectives Individuals with episodic amnesia are not stuck in time
a b s t r a c t The metaphor that individuals with episodic amnesia due to hippocampal damage are "stuck in time" persists in science, philosophy, and everyday life despite mounting evidence that episodic amnesia can spare many central aspects of temporal consciousness. Here we describe some of this evidence, focusing specifically on KC, one of the most thoroughly documented and severe cases of episodic amnesia on record. KC understands the concept of time, knows that it passes, and can orient himself with respect to his personal past and future. He expresses typical attitudes toward his past and future, and he is able to make future-regarding decisions. Theories claiming that the hippocampus plays an essential role in temporal consciousness need to be revised in light of these findings
Prediction and Topological Models in Neuroscience
In the last two decades, philosophy of neuroscience has predominantly focused on explanation. Indeed, it has been argued that mechanistic models are the standards of explanatory success in neuroscience over, among other things, topological models. However, explanatory power is only one virtue of a scientific model. Another is its predictive power. Unfortunately, the notion of prediction has received comparatively little attention in the philosophy of neuroscience, in part because predictions seem disconnected from interventions. In contrast, we argue that topological predictions can and do guide interventions in science, both inside and outside of neuroscience. Topological models allow researchers to predict many phenomena, including diseases, treatment outcomes, aging, and cognition, among others. Moreover, we argue that these predictions also offer strategies for useful interventions. Topology-based predictions play this role regardless of whether they do or can receive a mechanistic interpretation. We conclude by making a case for philosophers to focus on prediction in neuroscience in addition to explanation alone
Bradyzoite pseudokinase 1 is crucial for efficient oral infectivity of the Toxoplasma gondii tissue cyst.
The tissue cyst formed by the bradyzoite stage of Toxoplasma gondii is essential for persistent infection of the host and oral transmission. Bradyzoite pseudokinase 1 (BPK1) is a component of the cyst wall, but nothing has previously been known about its function. Here, we show that immunoprecipitation of BPK1 from in vitro bradyzoite cultures, 4 days postinfection, identifies at least four associating proteins: MAG1, MCP4, GRA8, and GRA9. To determine the role of BPK1, a strain of Toxoplasma was generated with the bpk1 locus deleted. This BPK1 knockout strain (Îbpk1) was investigated in vitro and in vivo. No defect was found in terms of in vitro cyst formation and no difference in pathogenesis or cyst burden 4 weeks postinfection (wpi) was detected after intraperitoneal (i.p.) infection with Îbpk1 tachyzoites, although the Îbpk1 cysts were significantly smaller than parental or BPK1-complemented strains at 8 wpi. Pepsin-acid treatment of 4 wpi in vivo cysts revealed that Îbpk1 parasites are significantly more sensitive to this treatment than the parental and complemented strains. Consistent with this, 4 wpi Îbpk1 cysts showed reduced ability to cause oral infection compared to the parental and complemented strains. Together, these data reveal that BPK1 plays a crucial role in the in vivo development and infectivity of Toxoplasma cysts
Giving Intention versus Giving Behavior: How Differently Do Satisfaction, Trust and Commitment Relate to Them?
On the Gold Standard for Security of Universal Steganography
While symmetric-key steganography is quite well understood both in the
information-theoretic and in the computational setting, many fundamental
questions about its public-key counterpart resist persistent attempts to solve
them. The computational model for public-key steganography was proposed by von
Ahn and Hopper in EUROCRYPT 2004. At TCC 2005, Backes and Cachin gave the first
universal public-key stegosystem - i.e. one that works on all channels -
achieving security against replayable chosen-covertext attacks (SS-RCCA) and
asked whether security against non-replayable chosen-covertext attacks (SS-CCA)
is achievable. Later, Hopper (ICALP 2005) provided such a stegosystem for every
efficiently sampleable channel, but did not achieve universality. He posed the
question whether universality and SS-CCA-security can be achieved
simultaneously. No progress on this question has been achieved since more than
a decade. In our work we solve Hopper's problem in a somehow complete manner:
As our main positive result we design an SS-CCA-secure stegosystem that works
for every memoryless channel. On the other hand, we prove that this result is
the best possible in the context of universal steganography. We provide a
family of 0-memoryless channels - where the already sent documents have only
marginal influence on the current distribution - and prove that no
SS-CCA-secure steganography for this family exists in the standard
non-look-ahead model.Comment: EUROCRYPT 2018, llncs styl
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