356 research outputs found
Fluorescence imaging of amyloid formation in living cells by a functional, tetracysteine-tagged alpha-synuclein
Structural characterization of the intrinsically unfolded protein beta-synuclein, a natural negative regulator of alpha-synuclein aggregation
Cleaning activity among Labridae in the Azores: the rainbow wrasse Coris julis and the Azorean blue wrasse Centrolabrus caeruleus
Copyright © Cambridge University Press 2009.Cleaning interactions among the rainbow wrasse Coris julis and the azorean blue wrasse Centrolabrus caeruleus are presented with photographic registers, as well as the first record of the latter cleaning conspecifics from Azorean shallow rocky reefs
Rocky reef fish community structure in two Azorean islands (Portugal) central North Atlantic
Copyright © Cambridge University Press 2010.The community structure of shallow rocky reef fish fauna of the Azores Archipelago is described from underwater visual censuses carried out at eight areas (Terceira and Corvo Islands). A total of 52 fish species from 26 different families was observed, and the ten most abundant fish corresponded to 82.7% of all fish. Trophic categories are given for observed species with comments on distribution and densities along sampled depth strata. Mean densities along sampled strata were tested for significant differences. Sparidae, Labridae and Carangidae were the most speciose families being Diplodus sargus, Pagellus acarne, Coris julis, Thalassoma pavo and Tripterygion delaisi the most abundant species that consequently also accounted for the highest densities
Truncation method for Green's functions in time-dependent fields
We investigate the influence of a time dependent, homogeneous electric field
on scattering properties of non-interacting electrons in an arbitrary static
potential. We develop a method to calculate the (Keldysh) Green's function in
two complementary approaches. Starting from a plane wave basis, a formally
exact solution is given in terms of the inverse of a matrix containing
infinitely many 'photoblocks' which can be evaluated approximately by
truncation. In the exact eigenstate basis of the scattering potential, we
obtain a version of the Floquet state theory in the Green's functions language.
The formalism is checked for cases such as a simple model of a double barrier
in a strong electric field. Furthermore, an exact relation between the
inelastic scattering rate due to the microwave and the AC conductivity of the
system is derived which in particular holds near or at a metal-insulator
transition in disordered systems.Comment: to appear in Phys. Rev. B., 21 pages, 3 figures (ps-files
EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor
ACKNOWLEDGEMENTS We thank J. M. Valverde (IRB) as well as the NMR facilities of the University of Barcelona (CCiT UB) and the Instituto de Química Física Rocasolano (IQFR, CSIC) for their assistance in, respectively, protein production and NMR. This work was supported by IRB, ICREA (X.S.), Obra Social “la Caixa” (Fellowship to E.D.M. and CancerTec grants to X.S.) MICINN (CTQ2009-08850 to X.S.), MINECO (BIO2012-31043 to X.S.; CTQ2014-56361-P to A.R), Marató de TV3 (102030 to X.S. and 102031 to E.E.P) the COFUND programme of the European Commission (C.T.W.P., A. R. and X.S.), the European Research Council (CONCERT, contract number 648201, to X.S.), the Ramón y Cajal program of MICINN (RYC-2011-07873 to C.W.B.) the Serra Hunter Programme (E.E.P.) and AGAUR (SGR-2014-56RR14 to E.E.P). IRB Barcelona is the recipient of a Severo Ochoa Award of Excellence from MINECO (Government of Spain)Peer reviewedPostprin
Structural characterization of copper(II) binding to α-Synuclein: Insights into the bioinorganic chemistry of Parkinson's disease
The aggregation of α -synuclein (AS) is characteristic of Parkinson’s disease and other neurodegenerative synucleinopathies. We demonstrate here that Cu(II) ions are effective in accelerating AS aggregation at physiologically relevant concentrations without altering the resultant fibrillar structures. By using numerous spectroscopic techniques (absorption, CD, EPR, and NMR), we have located the primary binding for Cu(II) to a specific site in the N terminus, involving His-50 as the anchoring residue and other nitrogen oxygen donor atoms in a square planar or distorted tetragonal geometry. The carboxylate-rich C terminus, originally thought to drive copper binding, is able to coordinate a second Cu(II) equivalent, albeit with a 300-fold reduced affinity. The NMR analysis of AS–Cu(II) complexes reveals the existence of conformational restrictions in the native state of the protein. The metallobiology of Cu(II) in Parkinson’s disease is discussed by a comparative analysis with other Cu(II)-binding proteins involved in neurodegenerative disorders
Electric field dependence of pairing temperature and tunneling
Using the Bethe-Salpeter equation including high electric fields, the
dependence of the critical temperature of onsetting superconductivity on the
applied field is calculated analytically. The critical temperature of pairing
is shown to increase with the applied field strength. This is a new field
effect and could contribute to the explanation of recent experiments on field
induced superconductivity. From the field dependence of the Bethe-Salpeter
equation, the two--particle bound state solution is obtained as a resonance
with a tunneling probability analogous to the WKB solution of a single particle
confined in a potential and coupled to the electrical field.Comment: 4 pages 1 figure, revised version from 29.10.02, Rev. B in pres
Inelastic quantum transport in superlattices: success and failure of the Boltzmann equation
Electrical transport in semiconductor superlattices is studied within a fully
self-consistent quantum transport model based on nonequilibrium Green
functions, including phonon and impurity scattering. We compute both the drift
velocity-field relation and the momentum distribution function covering the
whole field range from linear response to negative differential conductivity.
The quantum results are compared with the respective results obtained from a
Monte Carlo solution of the Boltzmann equation. Our analysis thus sets the
limits of validity for the semiclassical theory in a nonlinear transport
situation in the presence of inelastic scattering.Comment: final version with minor changes, to appear in Physical Review
Letters, sceduled tentatively for July, 26 (1999
- …