11 research outputs found
Cholesterin und Triglyceride im Serum einer MĂŒnchner Bevölkerungsgruppe: Beziehungen zu Alter und Geschlecht
Transitioning Toward an Internet Culture: An Interorganizational Analysis of Identity Construction from Online Services to Intranets
A great deal of attention has been given to the Internetâs capacity to enable new and multiple presentations of the self â even to become a site for new identity construction. While we do not deny the potential of Internet technologies to transform contemporary social practices and the way we see the world and ourselves, a closer look at the transition from âolder â media and technologies to the Internet gives us a better understanding of how electronic discourses are being shaped. In this paper, we examine a few sites of identity, paying particular attention to the practices and technologies that shape presentations and interpellations of individuals, as well as the construction, deconstruction and reassemblage of collective identities. Using data from two empirical studies, we examine what has shaped the presentations and interpretations of online identities over the past decade. Interestingly, we see that creative uses of âolder â media, like online profiling, have set the stage for common uses of the Internet; and that constrained uses of Internet technologies, like intranets and extranets, allow corporations and governments to extend control over selfpresentations and to more effectively interpellate identities
The Urban Creative-Food Economy: Producing Food for the Urban Elite or Social Inclusion Opportunity?
Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia
Calcium ions (Ca2+) function as universal second messengers in eukaryotic cells, including immune cells. Ca2+ is crucial for peripheral T-lymphocyte activation and effector functions, and influences thymocyte selection and motility in the developing thymus. However, the role of Ca2+ signalling in early T-lymphocyte development is not well understood. Here we show that the inositol triphosphate receptors (IP(3)Rs) Ca2+ ion channels are required for proliferation, survival and developmental progression of T-lymphocyte precursors. Our studies indicate that signalling via IP(3)Rs represses Sox13, an antagonist of the developmentally important transcription factor Tcf-1. In the absence of IP3R-mediated Ca2+ signalling, repression of key Notch transcriptional targets-including Hes1-fail to occur in post beta-selection thymocytes, and mice develop aggressive T-cell malignancies that resemble human T-cell acute lymphoblastic leukemia (T-ALL). These data indicate that IP3R-mediated Ca2+ signalling reinforces Tcf-1 activity to both ensure normal development and prevent thymocyte neoplasia.Multidisciplinary SciencesSCI(E)[email protected]; [email protected]
Precariousness as time horizon : How poverty and social insecurity shape individuals' time perspectives
International audienc