532 research outputs found
Anatomical Observations on a Freemartin
During the spring quarter, 1952, of the gross anatomy laboratory, our group was assigned to a crossed shorthorn heifer. This heifer, in first pregnancy, had been purchased by the Anatomy Department and embalmed for the purpose of dissection
Quantifying the Biases of Spectroscopically Selected Gravitational Lenses
Spectroscopic selection has been the most productive technique for the
selection of galaxy-scale strong gravitational lens systems with known
redshifts. Statistically significant samples of strong lenses provide a
powerful method for measuring the mass-density parameters of the lensing
population, but results can only be generalized to the parent population if the
lensing selection biases are sufficiently understood. We perform controlled
Monte Carlo simulations of spectroscopic lens surveys in order to quantify the
bias of lenses relative to parent galaxies in velocity dispersion, mass axis
ratio, and mass density profile. For parameters typical of the SLACS and BELLS
surveys, we find: (1) no significant mass axis ratio detection bias of lenses
relative to parent galaxies; (2) a very small detection bias toward shallow
mass density profiles, which is likely negligible compared to other sources of
uncertainty in this parameter; (3) a detection bias towards smaller Einstein
radius for systems drawn from parent populations with group- and cluster-scale
lensing masses; and (4) a lens-modeling bias towards larger velocity
dispersions for systems drawn from parent samples with sub-arcsecond mean
Einstein radii. This last finding indicates that the incorporation of
velocity-dispersion upper limits of \textit{non-lenses} is an important
ingredient for unbiased analyses of spectroscopically selected lens samples. In
general we find that the completeness of spectroscopic lens surveys in the
plane of Einstein radius and mass-density profile power-law index is quite
uniform, up to a sharp drop in the region of large Einstein radius and steep
mass density profile, and hence that such surveys are ideally suited to the
study of massive field galaxies.Comment: Accepted for publication in Astrophys. J., June 7, 2012. In press. 9
pages, 5 figures, 1 tabl
Egalitarian justice and expected value
According to all-luck egalitarianism, the differential distributive effects of both brute luck, which defines the outcome of risks which are not deliberately taken, and option luck, which defines the outcome of deliberate gambles, are unjust. Exactly how to correct the effects of option luck is, however, a complex issue. This article argues that (a) option luck should be neutralized not just by correcting luck among gamblers, but among the community as a whole, because it would be unfair for gamblers as a group to be disadvantaged relative to non-gamblers by bad option luck; (b) individuals should receive the warranted expected results of their gambles, except insofar as individuals blamelessly lacked the ability to ascertain which expectations were warranted; and (c) where societal resources are insufficient to deliver expected results to gamblers, gamblers should receive a lesser distributive share which is in proportion to the expected results. Where all-luck egalitarianism is understood in this way, it allows risk-takers to impose externalities on non-risk-takers, which seems counterintuitive. This may, however, be an advantage as it provides a luck egalitarian rationale for assisting ‘negligent victims’
Multilayered printed circuit boards inspected by X-ray laminography
Technique produces high resolution cross-sectional radiographs with close interplane spacing for inspecting multilayer boards to be used in providing circuitry routing and module structural support
In defence of global egalitarianism
This essay argues that David Miller's criticisms of global egalitarianism do not undermine the view where it is stated in one of its stronger, luck egalitarian forms. The claim that global egalitarianism cannot specify a metric of justice which is broad enough to exclude spurious claims for redistribution, but precise enough to appropriately value different kinds of advantage, implicitly assumes that cultural understandings are the only legitimate way of identifying what counts as advantage. But that is an assumption always or almost always rejected by global egalitarianism. The claim that global egalitarianism demands either too little redistribution, leaving the unborn and dissenters burdened with their societies' imprudent choices, or too much redistribution, creating perverse incentives by punishing prudent decisions, only presents a problem for global luck egalitarianism on the assumption that nations can legitimately inherit assets from earlier generations – again, an assumption very much at odds with global egalitarian assumptions
Principles of Stakes Fairness in Sport
Fairness in sport is not just about assigning the top prizes to the worthiest competitors. It is also about the way the prize structure itself is organised. For many sporting competitions, although it may be acceptable for winners to receive more than losers, it can seem unfair for winners to take everything and for losers to get nothing. Yet this insight leaves unanswered some difficult questions about what stakes fairness requires and which principles of stakes fairness are appropriate for particular competitions. In this article I specify a range of different principles of stakes fairness (ten in total) that could regulate sporting competitions. I also put forward a theoretical method for pairing up appropriate principles of stakes fairness with given sporting competitions. Specifically, I argue that the underlying rationales for holding sporting competitions can provide useful guides for identifying appropriate principles of stakes fairness. I then seek to clarify and work through some of the implications of this method for a sample of real world controversies over sporting prize structures. I also attempt to refine the method in response to two possible objections from indeterminacy and relativism. Finally, I compare and contrast my conclusions with more general philosophical debates about justice
Axiomatic Bargaining Theory on Opportunity Assignments
This paper discusses issues of axiomatic bargaining problems over opportunity assignments. The fair arbitrator uses the principle of "equal opportunity" for all players to make the recommendation on re- source allocations. A framework in such a context is developed and several classical solutions to standard bargaining problems are reformulated and axiomatically characterized. Working Paper 06-4
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma.
Almost all genomic studies of breast cancer have focused on well-established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells. To address this we created a unique dataset of epithelial samples ductoscopically obtained from ducts leading to breast carcinomas and matched samples from ducts on the opposite side of the nipple. Here, we demonstrate that perturbations in mRNA abundance, with increasing proximity to tumour, cannot be explained by copy number aberrations. Rather, we find a possibility of field cancerization surrounding the primary tumour by constructing a classifier that evaluates where epithelial samples were obtained relative to a tumour (cross-validated micro-averaged AUC = 0.74). We implement a spectral co-clustering algorithm to define biclusters. Relating to over-represented bicluster pathways, we further validate two genes with tissue microarrays and in vitro experiments. We highlight evidence suggesting that bicluster perturbation occurs early in tumour development
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