Corrigendum to: Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): report of 1640 cases from EUROAPS registry

Rheumatology 2020;59:1306–1314. doi:https://doi.org/10.1093/rheumatology/kez419 In the original article, the affiliation of co-author Cecilia Beatrice Chighizola should have read: “Experimental Laboratory of Immunological and Rheumatologic Researches, Istituto Auxologico Italiano, IRCCS, Cusano Milanino, Milan, Italy”. These details have been corrected only in this corrigendum to preserve the published version of record

Distribution and outcomes of a phenotype-based approach to guide COPD management: Results from the CHAIN cohort

Rationale: The Spanish guideline for COPD (GesEPOC) recommends COPD treatment according to four clinical phenotypes: non-exacerbator phenotype with either chronic bronchitis or emphysema (NE), asthma-COPD overlap syndrome (ACOS), frequent exacerbator phenotype with emphysema (FEE) or frequent exacerbator phenotype with chronic bronchitis (FECB). However, little is known on the distribution and outcomes of the four suggested phenotypes. Objective: We aimed to determine the distribution of these COPD phenotypes, and their relation with one-year clinical outcomes. Methods: We followed a cohort of well-characterized patients with COPD up to one-year. Baseline characteristics, health status (CAT), BODE index, rate of exacerbations and mortality up to one year of follow-up were compared between the four phenotypes. Results: Overall, 831 stable COPD patients were evaluated. They were distributed as NE, 550 (66.2%); ACOS, 125 (15.0%); FEE, 38 (4.6%); and FECB, 99 (11.9%); additionally 19 (2.3%) COPD patients with frequent exacerbations did not fulfill the criteria for neither FEE nor FECB. At baseline, there were significant differences in symptoms, FEV1 and BODE index (all p<0.05). The FECB phenotype had the highest CAT score (17.1±8.2, p<0.05 compared to the other phenotypes). Frequent exacerbator groups (FEE and FECB) were receiving more pharmacological treatment at baseline, and also experienced more exacerbations the year after (all p<0.05) with no differences in one-year mortality. Most of NE (93%) and half of exacerbators were stable after one year. Conclusions: There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant differences in demographics, patient-centered outcomes and health care resources use

Antibacterial evaluation of Styrax pohlii and isolated compounds

The antibacterial activity of the compounds egonol (1) and homoegonol (2), of the crude ethanolic extract of Styrax pohlii (Styracaceae) aerial parts (EE), and of its n-hexane (HF), EtOAc (EF), n-BuOH (BF), and hydromethanolic (HMF) fractions was evaluated against the following microorganisms: Streptococcus pneumoniae (ATCC 6305), S. pyogenes (ATCC 19615), Haemophilus influenzae (ATCC 10211), Pseudomonas aeruginosa (ATCC 27853), and Klebsiella pneumoniae (ATCC 10031). The broth microdilution method was used for determination of the minimum inhibitory concentration (MIC) during preliminary evaluation of antibacterial activity. The EE yielded MIC values of 400 µg/mL for S. pneumoniae and P. aeruginosa and 300 µg/mL for H. influenzae. The HF and EF fractions exhibited enhanced antibacterial activity, with MIC values of 200 µg/mL against S. pneumoniae, but only EF displayed activity against H. influenzae (MIC 200 µg/mL). The best MIC value with compounds 1 and 2 (400 µg/mL) was obtained for (1) against S. pneumoniae and P. aeruginosa. Therefore, 1 exhibited weak antibacterial activity against these standard strains

Redescription and phylogenetic position of Ctenomys dorsalis Thomas 1900, an enigmatic tuco tuco (Rodentia, Ctenomyidae) from the Paraguayan Chaco

Ctenomys dorsalis is known only from its type specimen, a female preserved as skin without skull (except for the upper incisors) from an imprecise locality in the "Northern Chaco of Paraguay". Here, we report additional individuals of this species housed, since the 1940s, at the Field Museum of Natural History (Chicago, USA). Based on these specimens, which fully match the original description of this rodent, we provide novel information regarding its phylogenetic position, external and cranial morphology, and distribution. The analysis of mtDNA sequences supports the distinctiveness of this taxon and suggests its placement within the boliviensis group of Ctenomys. Our study highlights once more the importance of museum collections as repositories of biodiversity. © 2018 Walter de Gruyter GmbH, Berlin/Boston 2018

Microalgae-based biodiesel: A multicriteria analysis of the production process using realistic scenarios

10.1016/j.biortech.2013.07.145Microalgae-based biodiesel has several benefits over other resources such as less land use, potential cultivation in non-fertile locations, faster growth and especially a high lipid-to-biodiesel yield. Nevertheless, the environmental and economic behavior for high scale production depends on several variables that must be addressed in the scale-up procedure. In this sense, rigorous modeling and multicriteria evaluation are performed in order to achieve optimal topology for third generation biodiesel production. Different scenarios and the most promising technologies tested at pilot scale are assessed. Besides, the sensitivity analysis allows the detection of key operating variables and assumptions that have a direct effect on the lipid content. The deviation of these variables may lead to an erroneous estimation of the scale-up performance of the technology reviewed in the microalgae-based biodiesel process. The modeling and evaluation of different scenarios of the harvesting, oil extraction and transesterification help to identify greener and cheaper alternatives

Sustainability analysis of biodiesel production from Cynara Cardunculus crop

10.1016/j.fuel.2013.04.02

Antibacterial evaluation of Styrax pohlii and isolated compounds

The antibacterial activity of the compounds egonol (1) and homoegonol (2), of the crude ethanolic extract of Styrax pohlii (Styracaceae) aerial parts (EE), and of its n-hexane (HF), EtOAc (EF), n-BuOH (BF), and hydromethanolic (HMF) fractions was evaluated against the following microorganisms: Streptococcus pneumoniae (ATCC 6305), S. pyogenes (ATCC 19615), Haemophilus influenzae (ATCC 10211), Pseudomonas aeruginosa (ATCC 27853), and Klebsiella pneumoniae (ATCC 10031). The broth microdilution method was used for determination of the minimum inhibitory concentration (MIC) during preliminary evaluation of antibacterial activity. The EE yielded MIC values of 400 µg/mL for S. pneumoniae and P. aeruginosa and 300 µg/mL for H. influenzae. The HF and EF fractions exhibited enhanced antibacterial activity, with MIC values of 200 µg/mL against S. pneumoniae, but only EF displayed activity against H. influenzae (MIC 200 µg/mL). The best MIC value with compounds 1 and 2 (400 µg/mL) was obtained for (1) against S. pneumoniae and P. aeruginosa. Therefore, 1 exhibited weak antibacterial activity against these standard strains

Los mamíferos amenazados del Paraguay

Se evaluaron 178 especies, excluyendo al tapiti Sylvilagus brasiliensis y al Dasypus septemcinctus (ver capítulo Xenarthra). Entre las especies evaluadas, se resalta que 29 especies fueron catalogadas como ?datos insuficientes? o DI, esto significa que la información disponible sobre estas especies en nuestro país es tan escasa que no podemos definir cuál es su estado de conservación a nivel nacional. Esta situación se debe a que existen pocos registros de la especie hasta el momento, pero la causa de ello es desconocida. Se podría Dar el caso de que la especie dada tenga una población abundante, pero hay pocas investigaciones (o ninguna) realizadas sobre el tema o bien, o caso contrario, que las especies posean pequeños tamaños poblacionales, sean de difícil avistamiento por lo que el esfuerzo de muestreo es escaso o inexistente (no se los busco). Esto resalta la importancia de la investigación en mastozoología para poder tomar decisiones de conservación, ya que, sin investigación científica, es imposible trazar acciones de conservación prácticas y fiables a nivelpaís y regional.Fil: Saldivar, S.. Asociación Paraguaya de Mastozoología; ParaguayFil: Rojas, V.. Asociación Paraguaya de Mastozoología; Paraguay. Asociacion Guyra Paraguay (guyra); Paraguay. Programa Nacional de Incentivo a los Investigadores; ParaguayFil: Giménez, D.. Asociación Paraguaya de Mastozoología; Paraguay. Sociedad para la Preservación de Carnívoros en Peligro y su Estudio Ecológico Internacional; Estados UnidosFil: Abba, Agustin Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Estudios Parasitológicos y de Vectores. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Estudios Parasitológicos y de Vectores; ArgentinaFil: Ayala, R.. Universidad de Buenos Aires; Argentina. Asociación Paraguaya de Mastozoología; ParaguayFil: Barreto, R.. Secretaría del Ambiente; ParaguayFil: Cartes, J.L.. Asociación Paraguaya de Mastozoología; Paraguay. Asociacion Guyra Paraguay (guyra); Paraguay. Programa Nacional de Incentivo a los Investigadores; ParaguayFil: del Castillo, H.. Asociacion Guyra Paraguay (guyra); Paraguay. Programa Nacional de Incentivo a los Investigadores; ParaguayFil: Cuéllar, E.. No especifíca;Fil: de la Sancha, N.U.. Asociación Paraguaya de Mastozoología; Paraguay. Chicago State University; Estados Unidos. Field Museum of National History; Estados UnidosFil: Gamarra de Fox, I.. Asociación Paraguaya de Mastozoología; Paraguay. Secretaría del Ambiente; ParaguayFil: Giordano, A.J.. Sociedad para la Preservación de Carnívoros en Peligro y su Estudio Ecológico Internacional; Estados UnidosFil: Kowalewski, Miguel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia". Estación Biológica de Usos Múltiples (Sede Corrientes); ArgentinaFil: López, J.. Asociación Paraguaya de Mastozoología; Paraguay. Universidad de Buenos Aires; ArgentinaFil: Martínez, V.. Asociación Paraguaya de Mastozoología; Paraguay. Itaipu Binacional; ParaguayFil: Mujica, N.. Universidad Nacional de Asunción; ParaguayFil: Neris, N.. Asociación Paraguaya de Mastozoología; Paraguay. Secretaría del Ambiente; ParaguayFil: Ortiz, M.L.. Asociación Paraguaya de Mastozoología; ParaguayFil: Ramírez, F.. Asociación Paraguaya de Mastozoología; Paraguay. Fundación Moisés Bertoni; ParaguayFil: Ríos, S.D.. Asociación Paraguaya de Mastozoología; Paraguay. Secretaría Nacional de Cultura; ParaguayFil: Ruíz Díaz, M.. Asociación Paraguaya de Mastozoología; ParaguayFil: Sánchez, J.. Asociación Paraguaya de Mastozoología; Paraguay. Universidad Nacional de Asunción; ParaguayFil: Smith, P.. Asociación Paraguaya de Mastozoología; Paraguay. Programa Nacional de Incentivo a los Investigadores; ParaguayFil: Stevens, R.. Texas Tech University; Estados UnidosFil: Teta, Pablo Vicente. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"; ArgentinaFil: Thompson, J.J.. Asociación Paraguaya de Mastozoología; Paraguay. Asociacion Guyra Paraguay (guyra); ParaguayFil: Torres, J.. Asociación Paraguaya de Mastozoología; ParaguayFil: Velázquez, M.. Asociación Paraguaya de Mastozoología; Paraguay. Fundación Moisés Bertoni; ParaguayFil: Velilla, M.. Asociación Paraguaya de Mastozoología; Paraguay. Asociacion Guyra Paraguay (guyra); Paraguay. Programa Nacional de Incentivo a los Investigadores; ParaguayFil: Villalba, L.. Asociación Paraguaya de Mastozoología; Paraguay. Wildlife Conservation Society; ParaguayFil: Weiler, A.. Asociación Paraguaya de Mastozoología; Paraguay. Programa Nacional de Incentivo a los Investigadores; Paraguay. Universidad Nacional de Asunción; Paragua