Conjectures of Mathematical Logic and Educational Games for Basic Education Based on the Guidelines of NCP, NCG and NBC

Current technological advances allow us to create, adapt or simply use numerous resources to achieve improvements in teaching-learning. The purpose of this article is to show the result of an analysis of the current normative documents and recommendations for national education in Brazil (National Curricular Guidelines - National Curricular Parameters and National Common Curricular Base), primary and secondary education, regarding the contents recommended in mathematical logic, complementing with the analysis of a pedagogical political project of the fundamental education of a public school, to verify the existence of this content, in it. From this analysis and reflection on the importance of educational games in teaching, the article proposes the development of an educational game especially to assist in teaching the functionalities on the symbols of logic. It highlights the contribution of this game to the teaching-learning of these rules and symbols and, finally, concludes by showing the importance of this activity in the educational process

The NMR-derived solution structure of a new cationic antimicrobial peptide from the skin secretion of the anuran Hyla punctata.

Amphibian skin secretions constitute an important source of molecules for antimicrobial drug research in order to combat the increasing resistance of pathogens to conventional antibiotics. Among the various types of substances secreted by the dermal granular amphibian glands, there is a wide range of peptides and proteins, often displaying potent antimicrobial activities and providing an effective defense system against parasite infection. In the present work, we report the NMR solution structure and the biological activity of a cationic 14-residue amphiphilic alpha-helical polypeptide named Hylaseptin P1 (HSP1), isolated from the skin secretion of the hylid frog Hyla punctata. The peptide antimicrobial activity was verified against Candida albicans, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, whereas no significant lytic effect was detected toward red or white blood cells