An Study On Organizational Climate Of The Selected Sugar Mills In Tamil Nadu

The organisational atmosphere is the common experience of workers who work and live in the organisation. It is the sum of people's opinions about an organization's procedures, policies, and activities. It represents the psychological environment of the company, which is made up of individual perspectives framed over time on micro events that affect them and those around them. It is a set of measurable work environment characteristics that have an effect on the participants' job and happiness, either directly or indirectly. Employees' knowledge of organisations and their work is shaped and enhanced by organisational climate variables. With innovative individual motivation to exchange knowledge among group members, a cooperative environment unlocks the right to use among group members and offers more efficiency. In order to boost the country's economic situation, corporate management should strive to create a welcoming organisational atmosphere. The sugar industry plays a complementary role in generating foreign exchange. Apart from text tails, the sugar industry is the largest in the manufacturing sector, employing thousands of technicians and a shortage of trained and unskilled workers. Thousands of people are still involved in the sugar trade and the transportation of sugar cane. As a result, the study focuses primarily on the organisational climate of selected sugar mills in Tamil Nadu

A Prospective study of Earlier Prediction of Lung Toxicity in Patients receiving Bleomycin for Hodgkin’s Lymphoma and Germcell Tumours

BACKGROUND: Bleomycin is one of the important chemotherapy commonly given for the treatment of Hodgkin lymphoma and germ-cell tumours, the most highly curable cancers. But bleomycin can cause severe life-threatening lung injury, which ranges from hypersensitivity pneumonitis and bronchiolitis obliterans organizing pneumonia (BOOP) to acute interstitial pneumonia and progressive pulmonary fibrosis. Hence, early diagnosis, treatment, and prevention of limiting toxicities such as bleomycin-induced lung injury, is very important. This study aims at of earlier prediction of bleomycin induced lung toxicity in hodgkin’s lymphoma & germcell tumours. AIMS AND OBJECTIVES: To identify the patients developing lung toxicity for Bleomycin in hodgkin’s lymphoma and germcell tumourby PFT and HRCT. MATERIALS AND METHODS: STUDY POPULATION: The study is conducted on 30 patients admitted to Government Rajaji Hospital & Madurai Medical College during the study period from March 2018 to August 2018. Inclusion criteria: Newly diagnosed Hodgkins lymphoma and germ cell tumour patients with age more than 18 years confirmed by histopathological examination and immunohistochemistry. Exclusion Criteria: Underlying lung disease. METHOD OF DATA COLLECTION: Hodgkin’s lymphoma and germ cell tumour patients of varying age and sex were selected their consent was taken. The history was elicited. Age, height weight were recorded. Thorough clinical examination were carried out. Design of Study: Prospective and observational study. Period of Study: Six months (March 2018 to August 2018). The performance of baseline PFT was carried out. In all the patients relevant information will be collected in a predesigned proforma. The patients are selected based on clinical examinations, histopathological examination and immunohistochemistry. The patients are followed over a period of 6 months with pulmonary function test and HRCT at regular intervals.Complete blood count,Liver function test, Renal function test, Sputum AFB, Sputum Culture and sensitivity, HPE, IHC, Chest X ray, PFT, HRCT will be done in all patients to screen for pre existing lung disease. RESULT: Totally 30 patients among which 18 hodgkin’s lymphoma and 12 germ cell tumour patients admitted in the Govt. Rajaji Hospital were studied for bleomycin induced lung toxicity during march 2018 to August 2018. Selected patients were free from previous lung disease as screened by PFT and HRCT. After completing the course of chemotherapy for HL and GCT patients they were assessed. 12 patients developed symptoms among which 9 had dry cough and 3 had dyspnoea. All patients were subjected to PFT at the end of the treatment. 9 of them developed abnormal PFT in the form of obstruction in 5 patients, restrictive pattern in 3 patients and mixed form in 1 patient. When HRCT was repeated for these patients they did not show any abnormality. Since bleomycin toxicity is not only dose dependent these patients have to be further followed up from earlier course of treatment to a minimum of 2 years for earlier identification of bleomycin induced toxicity. CONCLUSION: Bleomycin-induced lung injury is a major pulmonary toxicity. The mortality of this complication is high, ranging from 10 to 20%, and significantly impacts quality of life and five-year overall survival. The diagnosis of interstitial lung disease and BIP is particularly challenging and often depends on clinical, radiological, and cytological findings. Progress in understanding the mechanisms behind the therapeutic efficacy and unwanted toxicity of bleomycin, as well as elucidation of its biosynthetic pathway, may lead to the development of agents capable of preventing or treating BIP. Until then, physicians administrating bleomycin should be aware of potential lung toxicity, especially in the presence of risk factors

Development and Characterisation of Simvastatin Loaded Chitosan Nanoparticles for Sustained Drug Delivery

AIM AND PLAN OF WORK:To formulate Simvastatin loaded Chitosan Nanoparticle To carry out the Characterization of Simvastatin Nanoparticles Identification and confirmation of purity of drug by UV Spectrophotometry. Pre-formulation studies Drug polymer compatibility studies Evaluation of Nanoparticles Entrapment efficiency, Loading efficiency, Percentage yield, Drug content, Solubility studies, Drug particle size analysis by SEM, In-vitro drug release studies, In-vivo studies of nanoparticles as per the CPCSEA guidelines.SUMMARY AND CONCLUSION:The present work involves the formulation development, optimization, in-vitro and in-vivo evaluation of Simvastatin loaded Chitosan nanoparticles for sustained release. The Simvastatin, Chitosan were found to be compatible in FTIR study and DSC studies. The Simvastatin Nanoparticles were prepared by Nanoprecipitation method. Various concentration of chitosan were used to prepare Simvastatin nanoparticles and the maximum drug loading was found in F3. SEM study showed that prepared nanoparticles were spherical in shape with a smooth surface. Particle size of prepared nanoparticles was found to be in the range between 360nm and 480nm. In-vitro drug release of the optimized formulation shows 95.66% release at the end of 12 hours. The release kinetics of the optimized Nanoparticles showed that it follows zero order release kinetics. The release of the drug from Nanoparticles was found to be by diffusion and Non-fickian release. Stability studies of optimized nanoparticles were carried out according to ICH guidelines. It indicated that the Nanoparticles are stable and does not show any significant changes physical characteristics, drug content and dissolution. The comparative in vivo hypolipidemic activity performed on albino rats, after 21days of treatment, showed that plasma CH and TG levels were significantly lower (98.34±0.596 mg/dl, 84.56±0.55 mg/dl respectively) (p < 0.01). HDL-CH levels were significantly higher (36.29±0.602 mg/dl, p <0.01) in TTG compared to RTG.TTG showed a significantly better in vivo performance than RTG in terms of plasma lipid profile. The maximum percentage reduction of lipid levels were observed with Simvastatin nanoparticles. From the overall results, it is clear that the formulation F3 containing 1:3 drug: polymer ratio is the optimal formulation, as it produces sustained drug release

Characterization of Zinc-Iron alloy electrodeposits for corrosion resistance

Zinc alloy plating is a high performance coatirrg. Compared to pure zinc plating, zinc alloys provide several advantages. A zinc alloy will generally provide superior sacrificial protection to steel. The degree of protection and rate of corrosion depends on the alloy metal and composition. The demand for higher-quali~~lo, nger-lasting, more corrosion-resistant coatings in industries such as aerospace. fkstener, electrical component and particularly, automotive has played a large role in the rlevelopment and use of zinc alloy coatings. Zinc-iron alloy has good weldabilily and ductility. In this paper the corrosion resistance properties of zinc-iron deposited from a sulphate bath are evaluated by electrochemical methods and the results are discussed

Giant-cell tumors of bone in South India

Giant-cell tumors of bone are rare or uncommon. Dodge reported that giant-cell tumor is rare in Ugandan Africans, but Hadley and associates and Rockwell and Small noted that giant-cell tumor of bone is comparatively common in South India. In this paper we give an account of the general prevalence of giant-cell tumors of bone in our part of South India

Critically Vulnerable Coastal Areas - A Framework for Community Based Resource Management: Vembanad, Kerala 2016

The Sustainable Development Goal (SDG) 14 emphasizes Conservation and Sustainable use of the oceans, seas and marine resources for sustainable development. Further, India's National Conservation Strategy and Policy Statement on Environmental and Development, 1992 and the National Environmental Policy, 2006 recognize the importance of multi stakeholder partnership in implementation of conservation plans for sustainable development of natural resources

Pancreatic cancer: Incidence, clinical profile, and frequency of associated factors in Kuwait

Background: Pancreatic cancer is an uncommon tumor, but because the mortality rate approaches 100%, this form of cancer has now become a common cause of cancer mortality. Diabetes has been postulated to be both a risk factor and a consequence of pancreatic cancer, but the degree of risk and associated clinical factors remain unclear.Objectives: The objectives of this study were to investigate the incidence, clinical profile, and the frequency of associated factors of pancreatic cancer in Kuwait.Methods: The study design was a retrospective hospital-based record study in which records of 251 pancreatic cancer patients registered, evaluated and treated at Kuwait cancer control center from January 2004 through December 2010 were studied.Results: The overall pancreatic cancer incidence was 0.9/100000 population. Pancreatic cancer was more frequent in older, obese, smoker, diabetic Kuwaiti males with family history of pancreatic cancer. Metastasis was diagnosed in 67.7% of patients at diagnosis of pancreatic cancer.Conclusions: Pancreatic cancer in Kuwait is diagnosed in late stages. Screening for this disease was indicated specially in diabetic patients. A comprehensive comparative study is required for determination of risk factors that could be associated with the disease.Keywords: Pancreatic cancer; Profile; Diabetes mellitu

Analytical Study of Base Isolation- A Review

Now a days the rate of happening of seismic events increasing and due to that so many structures got collapsed or damaged. In order to reduce the damage to structures during earthquakes, now a days the base isolation system is widely adopted and used over the world. This paper makes a wide review on the various base isolation techniques adopted and used. Different types of isolating bearings and materials used in it are reviewed. Here the review is done for the isolation system in normal R.C buildings (regular and irregular in plan) and also for bridges. The effect of base isolation system on some historic structures is also reviewed. The various advantages and disadvantages of different isolating bearings are reviewed. Here the effect of temperature on some isolating devices are also reviewed

Prospective nutritional, therapeutic, and dietary benefits of camel milk making it a viable option for human consumption: Current state of scientific knowledge

For over five thousand years, people in Asia and Africa have known about the health benefits of camel milk. Thus, it is used not only as a food source but also as a medicine. The similarities between camel milk and human milk have been scientifically proven. Camel milk is unique among ruminant milk because it is high in vitamins C and E and low in sugar and cholesterol. Still, it contains a wide variety of beneficial minerals (including sodium, potassium, iron, copper, zinc, and magnesium), besides being rich in several nutrients, including monounsaturated and polyunsaturated fatty acids, serum albumin, lactoferrin, immunoglobulins, lysozyme and the hormone insulin. Because of these components, many medical professionals now recommend camel milk as a treatment for various human ailments. It has been demonstrated to be effective in treating gastrointestinal issues, Type 1 diabetes, and food allergies. As a bonus, camel milk has been utilized to cure autism, lower cholesterol, prevent psoriasis, heal inflammation, aid tuberculosis patients, boost the body's natural defences, and impede the spread of cancer cells. Those who have problems digesting lactose may still be able to tolerate it. Conversely, camel milk can also help reduce an excessively high bilirubin, globulin, and granulocyte count. Drinking camel milk does not affect the erythrocyte sedimentation rate, hemoglobin concentration, and leukocyte count. The proteins in camel milk have an adequate ratio of critical amino acids. Immunoglobulins, which fight disease, are contained inside, and their small size allows antigens to penetrate and boosts the immune system's efficacy. This article highlights the health benefits and medicinal uses of camel milk

Analysis of bioactive compounds from Gracilaria foliifera based on lunar phases

Gracilaria foliifera, sustainable renewable resources in the marine environment. Gracilaria, a genus of red algae, notable for its economic importance as an agarophyte. In the present study, experiments were performed to investigate the phytochemical constituents of Gracilaria foliifera. Samples were collected during three different lunar phases namely new moon, full moon and between days. The collected seaweeds were shade dried and extracted by ethyl acetate. The crude metabolites are subjected to phytochemical analysis, antioxidant activity, and qualitative analysis of the compounds by TLC. Further the crude extract was evaluated by GCMS. Among the different lunar phases, the presence of phytochemical compounds, antioxidants activity, is maximum during the full moon days which also showed appreciable amount than the samples collected during new moon phase and transition phase