[5-(2-Fur­yl)-6-nitro-1,2,3,5,6,7-hexa­hydro­imidazo[1,2-a]pyridin-8-yl](phen­yl)methanone

In the title compound, C18H17N3O4, the furyl and phenyl rings are inclined at almost right angles [85.77 (7) and 63.25 (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra­molecular N—H⋯O hydrogen bonding

(4-Fluoro­phen­yl)[6-(2-fur­yl)-7-nitro-2,3,4,6,7,8-hexa­hydro-1H-pyrido[1,2-a]pyrimidin-9-yl]methanone

In the title compound, C19H18FN3O4, the fused pyridine and pyrimidine rings adopt half-chair conformations. The structure displays intra­molecular N—H⋯O and inter­molecular N—H⋯F hydrogen bonding

Passive Reciprocal high-pass/low-pass 4-bit phase shifter at 2.45 GHz

This paper presents the design, fabrication and measurement of a low cost, reciprocal 4-bit phase shifter at 2.45 GHz ISM band using COTS components. High-pass/low-pass filters in π configuration are used to implement the phase shifter bit sections. SPDT switches are realized with BAP51 dual PIN diodes, with resonant inductors in the off-state to provide high isolation. The driver circuit consisting of 74AHC240 octal buffer/inverter was implemented to switch the PIN diodes and control the phase states. A compact layout of the 4-bit phase shifter and driver circuitry was fabricated on a 4-layer FR4 substrate. The total size of the PCB board was 4.9×5.3 cm. The measurement results showed an RMS phase error better than 4.1°, insertion loss better than 8.8 dB and return loss better than 13 dB. The maximum power consumption of the 4-bit phase shifter was 80 mW

Mobile-Based Applications:The Legal Challenges on Data Privacy

The mobile-based apps used is getting popular and continued to increased. Mobile user often downloaded the apps from various sources that provided from numerous of categorization of the application included health apps. Some of apps is optional to choose, but nevertheless, there are several apps is compulsory or must-action by citizens as instructed by the government or their agency. As for that, some issues of legal challenges on data privacy kin to data security have occurred. The issues on legal challenges is more intricate for non-legal educated users with non-awareness citizens while there are government involvements. Hence, in this paper, the issues and the legal challenges on the data privacy for mobile-based application are reviewed to give awareness for both side, the users (citizens) and apps provider (government or developer). Together with that, the idea of action, such as recommendation and option to react with the issues and challenges are also presented. Several Acts (legislation) are also proposed according to the legal issues and challenges that occurred, as showed the Personal Data Protection Act (PDPA) 2010 is became as the famous act used to confront with the existing privacy legislation in mobile-based application. The suggestions and recommendations might assist citizens to keep stand with their rights on data privacy issues in mobile apps, and to the other-side, it might provide some idea be more precise when create and develop the mobile apps.</p

Canonical Forms and Their Integrability for Systems of Three 2nd-Order ODEs

Differential invariants and their corresponding canonical forms for systems of three 2nd-order ODEs possessing three-dimensional Lie algebras are constructed. Their extension up to kth-order system of three 2nd-order ODEs is presented. Furthermore singularity in invariant structure for the canonical forms is investigated. In addition integrability of these canonical forms is discussed. Illustrative physical examples from mechanics of system of particles are provided

Understanding biological mechanisms underlying adverse birth outcomes in developing countries: Protocol for a prospective cohort (AMANHI bio-banking) study

Objectives: The AMANHI study aims to seek for biomarkers as predictors of important pregnancy-related outcomes, and establish a biobank in developing countries for future research as new methods and technologies become available.Methods: AMANHI is using harmonised protocols to enrol 3000 women in early pregnancies (8-19 weeks of gestation) for population-based follow-up in pregnancy up to 42 days postpartum in Bangladesh, Pakistan and Tanzania, with collection taking place between August 2014 and June 2016. Urine pregnancy tests will be used to confirm reported or suspected pregnancies for screening ultrasound by trained sonographers to accurately date the pregnancy. Trained study field workers will collect very detailed phenotypic and epidemiological data from the pregnant woman and her family at scheduled home visits during pregnancy (enrolment, 24-28 weeks, 32-36 weeks & 38+ weeks) and postpartum (days 0-6 or 42-60). Trained phlebotomists will collect maternal and umbilical blood samples, centrifuge and obtain aliquots of serum, plasma and the buffy coat for storage. They will also measure HbA1C and collect a dried spot sample of whole blood. Maternal urine samples will also be collected and stored, alongside placenta, umbilical cord tissue and membrane samples, which will both be frozen and prepared for histology examination. Maternal and newborn stool (for microbiota) as well as paternal and newborn saliva samples (for DNA extraction) will also be collected. All samples will be stored at -80°C in the biobank in each of the three sites. These samples will be linked to numerous epidemiological and phenotypic data with unique study identification numbers.Importance of the study: AMANHI biobank proves that biobanking is feasible to implement in LMICs, but recognises that biobank creation is only the first step in addressing current global challenges

Ensuring the Role and Impact: Reaching the Poorest While Alleviating the Poverty by Micro Finance in Dera Ismail Khan KPK Pakistan

Micro Finance is used as one of the tools for poverty alleviation.  Micro Financial Institutions provide small loans to poor people, farmers and small enterprises. It is the best solution of removing poverty. This research study provides an overview on Micro finance and poverty alleviation at D.I.Khan district KPK Pakistan.This study is based on both quantitative and qualitative methodologies in order to find out the feasible solution of thisresearch question:what are improvements achieved in the reduction of poverty in the fields of income, employment, education, communication, health care, children’s education and housing etc? Stratified random sampling techniques were used to get a total of 96 respondents. Data were collected through close ended questionnaires, semi structured interviews, observations and documentary reviews. Data analysis was based on descriptive statistics using various statistical tools like regression, correlation, t- test and ANNOVA with the help of tables. The Study findings show thatprovision of Micro-finance is very useful in poverty reduction. The result of the study also show that microfinance helps in poverty alleviation of different categories of poor people and has the positive significant impact on the dependent variable i.e. Poverty Reduction. Key words: Micro finance, poverty, MFIs, income, employment and education

Contraction and Intracellular Calcium Transport in Epicardial and Endocardial Ventricular Myocytes from Streptozotocin-Induced Diabetic Rat

Introduction: Diabetes mellitus (DM) is a global health problem. According to the International Diabetes Federation, 424.9 million people suffered from DM in 2017 and this number is expected to rise to 628.6 million by 2045. Although diabetes can affect every organ in the body, cardiovascular disease is a major cause of death and disability in people with diabetes. Diabetic patients frequently suffer from systolic and diastolic dysfunction. Within the ventricles, the electromechanical properties of cardiac myocytes vary transmurally. Aims and Objectives: The aim of this study was to investigate contraction and Ca2+ transport in epicardial (EPI) and endocardial (ENDO) myocytes from the left ventricle in the streptozotocin (STZ) “ induced diabetic rat heart. Materials and Methods: Experiments were performed 5-6 months after STZ treatment. Ventricular myocytes were isolated by enzymic and mechanical dispersal techniques from EPI and ENDO regions of the left ventricle. Contraction and free intracellular Ca2+ concentration [Ca2+]i were measured by video edge detection and fluorescence photometry techniques, respectively. Results: Myocyte length and calculated surface area were smaller in EPI-STZ compared to EPI-CON. Time to peak (TPK) shortening was prolonged in EPI-STZ compared to EPI-CON and in ENDO-STZ compared to ENDO-CON myocytes. Time to half (THALF) relaxation of shortening was prolonged in EPI-STZ compared to EPI-CON. TPK Ca2+ transient was prolonged in EPI-STZ compared to EPI-CON, ENDO-STZ compared to ENDO-CON, ENDO-STZ compared to EPI-STZ and in ENDO-CON compared to EPI-CON myocytes. THALF decay of the Ca2+ transient was prolonged in ENDO-STZ compared to ENDO-CON. Fractional release of Ca2+ was increased in ENDO-STZ compared to ENDO-CON and in ENDO-STZ compared to EPI-STZ. Recovery of the Ca2+ transient was prolonged in ENDO-STZ compared to ENDO-CON. Conclusion: In conclusion the kinetics of contraction and Ca2+ transient and fractional release of Ca2+ from the sarcoplasmic reticulum are altered to different extents in EPI and ENDO myocytes from STZ-induced diabetic rat

Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

Publisher Copyright: © 2022 Korean Stroke Society.Background and Purpose Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. Methods We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). Results There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. Conclusions During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT.Peer reviewe