Comprensión lectora 1, Secundaria : cuaderno de trabajo

Este material ha sido organizado en cuatro fichas, cada una de las cuales aborda algún tópico que recoge una problemática actual. Dentro de cada ficha, se hallará una situación de la vida real o simulada que implica un reto por afrontar y que te acercará a diversos contextos del Perú y del mundo. Mediante el desarrollo de las actividades y tareas, el alumno podrá elaborar productos que evidenciarán el desarrollo de tus competencias comunicativas. De este modo, se encontrará textos de diferentes géneros en cada ficha, con los cuales se busca que te acerques y familiarices con una diversidad de tipos textuales. Por medio de la lectura interactiva, se involucrará en la temática planteada para comprenderla y emprender la resolución del desafío de la ficha. Luego de los textos, se presentan algunas actividades de lectura, mediante las cuales queremos que profundices tu comprensión, y otras dirigidas a la elaboración de los productos orales y escritos, que favorecerán el desarrollo de tus competencias de escritura y oralidad

Fichas de aprendizaje de Comunicación 1

Proponemos trabajar las seis fichas de forma flexible y libre, con el compromiso de que tú y tu docente planifiquen y desarrollen las actividades propuestas. Al interior de las fichas, hallarás una situación de la vida real o simulada que implica resolver un reto que te acercará a diversos contextos del Perú y del mundo. En ese sentido, ponemos a tu disposición diversos tipos y géneros textuales que, mediante la realización de actividades, elaboración de productos y evidencias, potenciarán el desarrollo de tus competencias comunicativas. En cada ficha se propone la siguiente secuencia: primero, te presentamos una situación con preguntas a modo de reto; seguidamente, te invitamos a leer la diversidad de textos propuestos, los cuales te permitirán involucrarte en los temas planteados para comprenderlos e interpretarlos, y con los que podrás desarrollar las actividades de lectura —por medio de las cuales queremos que profundices tu comprensión—, y otras dirigidas a la elaboración de los productos orales y escritos

IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19

Interferons (IFNs) are a group of cytokines with antiviral, antiproliferative, antiangiogenic, and immunomodulatory activities. Type I IFNs amplify and propagate the antiviral response by interacting with their receptors, IFNAR1 and IFNAR2. In COVID-19, the IFNAR2 (interferon alpha and beta receptor subunit 2) gene has been associated with the severity of the disease, but the soluble receptor (sIFNAR2) levels have not been investigated. We aimed to evaluate the association of IFNAR2 variants (rs2236757, rs1051393, rs3153, rs2834158, and rs2229207) with COVID-19 mortality and to assess if there was a relation between the genetic variants and/or the clinical outcome, with the levels of sIFNAR2 in plasma samples from hospitalized individuals with severe COVID-19. We included 1,202 subjects with severe COVID-19. The genetic variants were determined by employing Taqman® assays. The levels of sIFNAR2 were determined with ELISA in plasma samples from a subgroup of 351 individuals. The rs2236757, rs3153, rs1051393, and rs2834158 variants were associated with mortality risk among patients with severe COVID-19. Higher levels of sIFNAR2 were observed in survivors of COVID-19 compared to the group of non-survivors, which was not related to the studied IFNAR2 genetic variants. IFNAR2, both gene, and soluble protein, are relevant in the clinical outcome of patients hospitalized with severe COVID-19

Plant improvement by known-function genes

Plant molecular improvement by recombinant DNA technology represents an advantage to obtain new varieties or traits. This technique is promised for genetic improvement of crop plants. Lines with increased yield, quality, disease resistance, or tolerant to abiotic stress have been obtained, with clear advantages for producers, marketers and consumers. However, they have several limitations in its application to agriculture because of its risk and hazards. The aim of the document is to show the advantages and disadvantages of GM crop plant, to develop represent an opportunity to have new exotic traits

Mejoramiento vegetal usando genes con funciones conocidas

El mejoramiento de plantas mediante la inserción de un fragmento de ADN usando ingeniería genética representa una oportunidad para desarrollar cultivares o variedades con características económicamente deseables, como conferir ventajas adaptativas al medio ambiente, mejores propiedades nutrimentales y disminución del uso de agroquímicos. Dada la polémica alrededor de este tipo de tecnologías la justificación de su desarrollo y uso dependerá del entorno socio-cultural y deberá ser estudiado caso por caso. El presente documento tiene el objetivo de plantear un panorama de los Organismos Genéticamente Modificados (OGM), sus ventajas y desventajas, y establecer el porqué constituyen una oportunidad para desarrollar cultivares con características que por métodos tradicionales no podrían obtenerse

A Global Screening Assay to Select for Maize Phenotypes with a High Tolerance or Resistance to Fusarium verticillioides (Sacc.) Nirenberg Rots

Fusarium verticillioides (Sacc.) Nirenberg (Fv) causes rots in maize around the world and produces mycotoxins that contaminate grains, making this species a significant health concern for both animals and humans. One of the best approaches to address rots is to identify highly tolerant or resistant genotypes that can be used for genetic improvement. The aim of the study was to evaluate dose-response assays to tolerance or resistance for Fv rots throughout the maize life cycle. These tests assessed the effects of Fv during post-germination development and the seedling (V2) stage by seed infection, the plantlet (V4) stage by substrate infection, and in the reproductive phase in maize stalks (R2 stage) and ears (R6 stage) by R1 stage inoculation. In all assays, the doses were effective at distinguishing contrasting phenotypes. Severity, root fresh weight, and aerial length were the most informative parameters at the V2 and V4 stages. Evaluation of the stalk necrosis area between and within the internodes of susceptible genotypes revealed significant differences among doses, and a positive correlation between necrosis and conidia concentration was observed in internodes. Injecting eight million conidia in the ear was sufficient for selecting different phenotypes. A total of 85% of the genotypes conserved their same capacity to respond to Fv infection throughout the maize life cycle, so that screening at the early vegetative stage (e.g., V2) could be useful for distinguishing contrasting phenotypes in the reproductive stage. Implementing these screening assays in a maize breeding program could be valuable for classifying the degrees of resilience of maize germplasms to Fv rots. This global screening has the potential to be employed to select against other Fusarium species

The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19

Tobacco smoking is the leading risk factor for many respiratory diseases. Several genes are associated with nicotine addiction, such as CHRNA5 and ADAM33. This research aims to evaluate the association of the polymorphisms rs16969968 (CHRNA5) and rs3918396 (ADAM33) in patients who developed severe COVID-19. We included 917 COVID-19 patients hospitalized with critical disease and oxygenation impairment. They were divided into two groups, tobacco-smoking (n = 257) and non-smoker (n = 660) patients. The genotype and allele frequencies of two single nucleotide variants, the rs16969968 (CHRNA5) and rs3918396 (ADAM33), were evaluated. The rs3918396 in ADAM33 does not show a significative association. We analyzed the study population according to the rs16969968 genotype (GA + AA, n = 180, and GG, n = 737). The erythrocyte sedimentation rate (ESR) shows statistical differences; the GA + AA group had higher values than the GG group (p = 0.038, 32 vs. 26 mm/h, respectively). The smoking patients and GA or AA genotype carriers had a high positive correlation (p < 0.001, rho = 0.753) between fibrinogen and C-reactive protein. COVID-19 patients and smokers carriers of one or two copies of the risk allele (rs16969968/A) have high ESR and a positive correlation between fibrinogen and C-reactive protein