Mexico's año horrible: global crisis stings economy

Initial optimism has been replaced by increasingly dire predictions for Mexico's near-term economic outlook in response to the global economic slump. World trade flows have dried up, which is particularly damaging for nations like Mexico whose economic activity depends critically on exports. At the same time, international financial uncertainty led investors to withdraw capital from emerging markets. Mexico was also confronted with a number of idiosyncratic shocks: a crackdown on drug cartels and local corruption, a flu epidemic and trade disputes with its most important partner. However, recent data suggest the financial system is exhibiting stability even as a severe recession plagues the country. This resilience demonstrates the strides Mexico has made toward reducing its financial vulnerability.Economic conditions - Mexico ; Recessions

Beyond the border: the politics of Brazil's financial troubles

International finance ; Brazil

Microphysical manifestations of viscosity and consequences for anisotropies in the very early universe

It has been known that a non-perfect fluid that accounts for dissipative viscous effects can evade a highly anisotropic chaotic mixmaster approach to a singularity. Viscosity is often simply parameterised in this context, so it remains unclear whether isotropisation can really occur in physically motivated contexts. We present a few examples of microphysical manifestations of viscosity in fluids that interact either gravitationally or, for a scalar field for instance, through a self-coupling term in the potential. In each case, we derive the viscosity coefficient and comment on the applicability of the approximations involved when dealing with dissipative non-perfect fluids. Upon embedding the fluids in a cosmological context, we then show the extent to which these models allow for isotropisation of the universe in the approach to a singularity. We first do this in the context of expansion anisotropy only, i.e., in the case of a Bianchi type-I universe. We then include anisotropic 3-curvature modelled by the Bianchi type-IX metric. It is found that a self-interacting scalar field at finite temperature allows for efficient isotropisation, whether in a Bianchi type-I or type-IX spacetime, although the model is not tractable all the way to a singularity. Mixmaster chaotic behaviour, which is well known to arise in anisotropic models including anisotropic 3-curvature, is found to be suppressed in the latter case as well. We find that the only model permitting an isotropic singularity is that of a dense gas of black holes

Cosmological consequences of a principle of finite amplitudes

Over 30 years ago, Barrow & Tipler proposed the principle according to which the action integrated over the entire 4-manifold describing the universe should be finite. Here we explore the cosmological consequences of a related criterion, namely that semi-classical transition amplitudes from the early universe up to current field values should be well defined. On a classical level, our criterion is weaker than the Barrow-Tipler principle, but it has the advantage of being sensitive to quantum effects. We find significant consequences for early universe models, in particular: eternal inflation and strictly cyclic universes are ruled out. Within general relativity, the first phase of evolution cannot be inflationary, and it can be ekpyrotic only if the scalar field potential is trustworthy over an infinite field range. Quadratic gravity eliminates all non-accelerating backgrounds near a putative big bang (thus imposing favourable initial conditions for inflation), while the expected infinite series of higher-curvature quantum corrections eliminates Lorentzian big bang spacetimes altogether. The scenarios that work best with the principle of finite amplitudes are the no-boundary proposal, which gives finite amplitudes in all dynamical theories that we have studied, and string-inspired loitering phases. We also comment on the relationship of our proposal to the swampland conjectures

Quintin C. Coleman, Tenor

6 Sacred Songs, Op. 48 / Ludwig van Beethoven; Five Songs of Laurence Hope / Harry T. Burleigh; Toujours / Gabriel Faure; À Chloris / Reynaldo Hahn; Le manoir de Rosamonde / Henri Duparc; Songs and Dances of Death / Modest Mussorgsk

Plasticity of fetal cartilaginous cells.

Tissue-specific stem cells found in adult tissues can participate in the repair process following injury. However, adult tissues, such as articular cartilage and intervertebral disc, have low regeneration capacity, whereas fetal tissues, such as articular cartilage, show high regeneration ability. The presence of fetal stem cells in fetal cartilaginous tissues and their involvement in the regeneration of fetal cartilage is unknown. The aim of the study was to assess the chondrogenic differentiation and the plasticity of fetal cartilaginous cells. We compared the TGF-β3-induced chondrogenic differentiation of human fetal cells isolated from spine and cartilage tissues to that of human bone marrow stromal cells (BMSC). Stem cell surface markers and adipogenic and osteogenic plasticity of the two fetal cell types were also assessed. TGF-β3 stimulation of fetal cells cultured in high cell density led to the production of aggrecan, type I and II collagens, and variable levels of type X collagen. Although fetal cells showed the same pattern of surface stem cell markers as BMSCs, both type of fetal cells had lower adipogenic and osteogenic differentiation capacity than BMSCs. Fetal cells from femoral head showed higher adipogenic differentiation than fetal cells from spine. These results show that fetal cells are already differentiated cells and may be a good compromise between stem cells and adult tissue cells for a cell-based therapy

Quintin C Coleman Jr., Tenor

Schwanengesang / Franz Schubert; Little David play on your harp; Weepin Mary; Oh, Rock me Julie / H.T. Burleigh; City Called Heaven / Hall Johnso

Trained immunity or tolerance : opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors

Article Accepted Date: 29 January 2014. ACKNOWLEDGMENTS D.C.I. received funding from the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement HEALTH-2010-260338 (“Fungi in the setting of inflammation, allergy and autoimmune diseases: translating basic science into clinical practices” [ALLFUN]) (awarded to M.G.N.). M.G.N. and J.Q. were supported by a Vici grant of the Netherlands Organization of Scientific Research (awarded to M.G.N.). This work was supported, in part, by National Institutes of Health grant GM53522 to D.L.W. N.A.R.G. was supported by the Wellcome Trust.Peer reviewedPublisher PD