Escroto agudo causado por una trombosis venosa extraespermática asociada con la mutación del gen de protrombina G20210A en un paciente pediátrico: reporte de un caso

Se ha informado que la trombosis de un vaso sanguíneo extraespermático es una causa inusual de escroto agudo. Describimos el caso de un niño de 7 años que presentó una hinchazón escrotal izquierda dolorosa aguda. Las imágenes demostraron una masa escrotal izquierda heterogénea, que fue resecada quirúrgicamente. El estudio anatomopatológico reveló una estructura vascular trombosada. Tres meses después, se produjo otra trombosis venosa extraespermática y también se resecó. Se realizó un estudio completo de trombofilia. Se identificó una mutación heterocigótica del gen de protrombina G20210A como la causa del evento trombótico. Una trombosis venosa debe considerarse como una posible causa de escroto agudo en pacientes europeos caucásicos, debido a su mayor prevalencia. Revisamos la mutación del gen de protrombina G20210A, que está asociada con la trombosis.Thrombosis of an extraspermatic blood vessel has been reported to be an unusual cause of acute scrotum. We describe the case of a 7-year-old boy who presented with an acute painful left scrotal swelling. Imaging demonstrated a heterogeneous left scrotal mass, which was surgically resected. The anatomopathologic study revealed a thrombosed vascular structure. Three months later, another extraspermatic venous thrombosis occurred and was also resected. A complete thrombophilia study was done. A G20210A prothrombin gene heterozygous mutation was identified as the cause of the thrombotic event. A venous thrombosis should be considered as a possible cause of acute scrotum in European Caucasian patients, due to its increased prevalence. We reviewed the G20210A prothrombin gene mutation, which is associated with thrombosis

Escroto agudo causado por una trombosis venosa extraespermática asociada con la mutación del gen de protrombina G20210A en un paciente pediátrico: reporte de un caso

Se ha informado que la trombosis de un vaso sanguíneo extraespermático es una causa inusual de escroto agudo. Describimos el caso de un niño de 7 años que presentó una hinchazón escrotal izquierda dolorosa aguda. Las imágenes demostraron una masa escrotal izquierda heterogénea, que fue resecada quirúrgicamente. El estudio anatomopatológico reveló una estructura vascular trombosada. Tres meses después, se produjo otra trombosis venosa extraespermática y también se resecó. Se realizó un estudio completo de trombofilia. Se identificó una mutación heterocigótica del gen de protrombina G20210A como la causa del evento trombótico. Una trombosis venosa debe considerarse como una posible causa de escroto agudo en pacientes europeos caucásicos, debido a su mayor prevalencia. Revisamos la mutación del gen de protrombina G20210A, que está asociada con la trombosis.Thrombosis of an extraspermatic blood vessel has been reported to be an unusual cause of acute scrotum. We describe the case of a 7-year-old boy who presented with an acute painful left scrotal swelling. Imaging demonstrated a heterogeneous left scrotal mass, which was surgically resected. The anatomopathologic study revealed a thrombosed vascular structure. Three months later, another extraspermatic venous thrombosis occurred and was also resected. A complete thrombophilia study was done. A G20210A prothrombin gene heterozygous mutation was identified as the cause of the thrombotic event. A venous thrombosis should be considered as a possible cause of acute scrotum in European Caucasian patients, due to its increased prevalence. We reviewed the G20210A prothrombin gene mutation, which is associated with thrombosis

Basal characteristics of adult dominant polycystic kidney disease patients and a control group.

<p>Basal characteristics of adult dominant polycystic kidney disease patients and a control group.</p

Renal function of ADPKD patients according to htTKV tertiles.

<p>Renal function of ADPKD patients according to htTKV tertiles.</p

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: Prostate-vesicular transrectal ultrasound reference ranges and associations with clinical, seminal and biochemical characteristics

Transrectal ultrasound (TRUS) parameters are not standardized, especially in men of reproductive age. Hence, the European Academy of Andrology (EAA) promoted a multicenter study to assess the TRUS characteristics of healthy-fertile men (HFM) to establish normative parameters

The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: An overview on male genital tract ultrasound reference ranges

Background: So far, male genital tract color-Doppler ultrasound (MGT-CDUS) was not standardized. Recently, the European Academy of Andrology (EAA) published the results of a multicenter study assessing the CDUS characteristics of healthy-fertile men (HFM) to obtain normative parameters. Objectives: To report the EAA US study (i) standard operating procedures (SOPs) for assessing MGT-CDUS, (ii) main MGT-CDUS normative parameters, and (iii) compare the EAA and previously published "normal" CDUS values. Methods: A cohort of 248 HFM (35.3 ± 5.9 years) was studied, evaluating MGT-CDUS before and after ejaculation following SOPs. Results: SOPs for MGT-CDUS assessment are summarized here. All subjects underwent scrotal CDUS and 188 men underwent transrectal ultrasound before and after ejaculation. The main CDUS reference ranges and characteristics of the HFM-MGT are reported here. The mean testicular volume was ∼17 mL. The lower limit for right and left testis was 12 and 11 mL, defining testicular hypotrophy. The upper limit for epididymal head, body, tail, and vas deferens was 11.5, 5, 6, and 4.5 mm, respectively. Testicular and epididymal arterial reference ranges are reported. The EAA varicocoele classification is reported. CDUS-varicocoele was detected in ∼37% of men. Prostate mean volume was ∼25 mL, while lower and upper limits were 15 and 35 mL, defining hypotrophy and enlargement, respectively. Prostate arterial reference ranges are reported. Prostate calcifications and inhomogeneity were frequent; midline prostatic cysts were rare and small. Ejaculatory duct abnormalities were absent. The upper limit for periprostatic venous plexus was 4.5 mm. Lower and upper limits of seminal vesicles (SV) anterior-posterior diameter were 6 and 16 mm, defining hypotrophy or dilation, respectively. Seminal vesicle volume and ejection fraction reference ranges are reported. SV-US abnormalities were rare. Deferential ampullas upper limit was 6 mm. A discussion on the EAA and previously published "normal" CDUS values is reported here. Conclusions: The EAA findings will help in reproductive and general male health management