Shape selection of surface-bound helical filaments: biopolymers on curved membranes

Motivated to understand the behavior of biological filaments interacting with membranes of various types, we study a theoretical model for the shape and thermodynamics of intrinsically-helical filaments bound to curved membranes. We show filament-surface interactions lead to a host of non-uniform shape equilibria, in which filaments progressively unwind from their native twist with increasing surface interaction and surface curvature, ultimately adopting uniform-contact curved shapes. The latter effect is due to non-linear coupling between elastic twist and bending of filaments on anisotropically-curved surfaces, such as the cylindrical surfaces considered here. Via a combination of numerical solutions and asymptotic analysis of shape equilibria we show that filament conformations are critically sensitive to the surface curvature in both the strong- and weak-binding limits. These results suggest that local structure of membrane-bound chiral filaments is generically sensitive to the curvature-radius of the surface to which it is bound, even when that radius is much larger than the filament intrinsic pitch. Typical values of elastic parameters and interaction energies for several prokaryotic and eukaryotic filaments indicate that biopolymers are inherently very sensitive to the coupling between twist, interactions and geometry and that this could be exploited for regulation of a variety of processes such as the targeted exertion of forces, signaling and self-assembly in response to geometric cues including the local mean and Gaussian curvatures

Instructional Leadership, Teaching Quality, and Student Achievement: Suggestive Evidence from Three Urban School Districts

Does providing instruction-related professional development to school principals set in motion a chain of events that can improve teaching and learning in their schools? This report examines professional development efforts by the University of Pittsburgh's Institute for Learning in elementary schools in Austin, St. Paul, and New York City

My Alfond Grant CDA: Experience From 10 Years of Automatic Deposits for All Maine Newborns

For over a decade, the Alfond Scholarship Foundation has automatically enrolled every Maine-resident newborn into the United States’ first statewide, universal Child Development Account (CDA) by investing $500 on each child’s behalf in the NextGen 529 plan. This Policy Brief provides an overview of My Alfond Grant and tracks the growth of the CDA in the 10 years since it made the major policy-design change to implement automatic enrollment. The Brief also includes insights regarding partnerships and communications that have helped to improve My Alfond Grant’s ability to connect with Maine families

SAMplus: adaptive optics at optical wavelengths for SOAR

Adaptive Optics (AO) is an innovative technique that substantially improves the optical performance of ground-based telescopes. The SOAR Adaptive Module (SAM) is a laser-assisted AO instrument, designed to compensate ground-layer atmospheric turbulence in near-IR and visible wavelengths over a large Field of View. Here we detail our proposal to upgrade SAM, dubbed SAMplus, that is focused on enhancing its performance in visible wavelengths and increasing the instrument reliability. As an illustration, for a seeing of 0.62 arcsec at 500 nm and a typical turbulence profile, current SAM improves the PSF FWHM to 0.40 arcsec, and with the upgrade we expect to deliver images with a FWHM of $\approx0.34$ arcsec -- up to 0.23 arcsec FWHM PSF under good seeing conditions. Such capabilities will be fully integrated with the latest SAM instruments, putting SOAR in an unique position as observatory facility.Comment: To appear in Proc. SPIE 10703 (Ground-based and Airborne Instrumentation for Astronomy VII; SPIEastro18

Experimental access to higher-order Zeeman effects by precision spectroscopy of highly charged ions in a Penning trap

We present an experimental concept and setup for laser-microwave double-resonance spectroscopy of highly charged ions in a Penning trap. Such spectroscopy allows a highly precise measurement of the Zeeman splittings of fine- and hyperfine-structure levels due the magnetic field of the trap. We have performed detailed calculations of the Zeeman effect in the framework of quantum electrodynamics of bound states as present in such highly charged ions. We find that apart from the linear Zeeman effect, second- and third-order Zeeman effects also contribute to the splittings on a level of 10^-4 and 10^-8, respectively, and hence are accessible to a determination within the achievable spectroscopic resolution of the ARTEMIS experiment currently in preparation

A pandemic lesson for global lung diseases: exacerbations are preventable.

A dramatic global reduction in the incidence of common seasonal respiratory viral infections has resulted from measures to limit the transmission of SARS2-Cov-19 during the pandemic . This has been accompanied by falls reaching 50% internationally in the incidence of acute exacerbations of pre-existing chronic respiratory diseases that include asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic Fibrosis (CF). At the same time, the incidence of acute bacterial pneumonia and sepsis has fallen steeply world-wide. Such findings demonstrate the profound impact of common respiratory viruses on the course of these global illnesses. Reduced transmission of common respiratory bacterial pathogens and their interactions with viruses appear also as central factors. This review summarises pandemic changes in exacerbation rates of asthma, COPD, Cystic Fibrosis (CF) and pneumonia. We draw attention to the substantial body of knowledge about respiratory virus infections in these conditions, and that it has not yet translated into clinical practice. Now the large-scale of benefits that could be gained by managing these pathogens is unmistakable, we suggest the field merits substantial academic and industrial investment. We consider how pandemic-inspired measures for prevention and treatment of common infections should become a cornerstone for managing respiratory diseases. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)