Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Extramedullary plasmacytoma (EMP) is an uncommon plasma cell neoplasm results from plasma cell proliferation and consists of monoclonal plasmacytic infiltration, without bone marrow involvement and any other systemic characteristics of multiple myeloma. EMP accounts for 3% of all plasma cell neoplasms and approximately 80% to 90% of EMP involve submucosa of the upper aerodigestive, while scrotal, dermis and retroperitoneal infiltration are very rare. There are no consensus guidelines for treatment, but EMP is highly radiosensitive, surgery may be considered for some sites, but 11 at 30% can progress in multiple myeloma. We report here an exceptional case of recurrent EMP in much localization. It's about a man 72 years old with initially testicular plasmocytoma who generalized the plasmacytic infiltration after 16 months in skin and progressively in mediastinal and retroperitoneal plasmacytoma, without any medullar and bone involvement.Pan African Medical Journal 2013; 14:3

Secondary Thymoma among Adult Treated For Acute Lymphoblastic Lymphoma/Leukemia: Report of a Case and Review of the Literature

BACKGROUND: Concomitant thymoma and T- lymphoblastic/leukaemia lymphoma is possible. Secondary thymoma after treatment for T-lymphoblastic/leukaemia lymphoma was also occasionally reported, although this is quite rare. CASE REPORT: We report a case of 44-year-old women with secondary thymoma after chemotherapy treatment for T Acute Lymphoblastic leukaemia/lymphoma. Diagnosis of lymphoblastic/leukaemia lymphoma was made in 2015 by morphological and histological study. The patient underwent Moroccan protocol for acute lymphoblastic leukaemia (MARALL) from 2015 to 2017 and achieved complete remission. One year later, the patient developed an anterior mediastinal mass, relapse was suspected, but the surgical biopsy was performed and histological, the mass showed thymoma. CONCLUSION: At the time of diagnosis of thymoma for a patient treated for T-lymphoblastic/leukaemia lymphoma it is necessary to eliminate a relapse because the distinction between thymoma and T-lymphoblastic/leukaemia lymphoma is sometimes difficult, and the association is possible

Eranet-Med Optimed- Water Project: Results on soil Moisture Maps of Semi-Arid Environment by using Optical/Microwave Satellite Data

This project deals with the implementation of an innovative water management system in Mediterranean countries (i.e. Tunisia and Egypt), which suffer from chronic water scarcity, together with two European countries (Germany and Italy). The consortium is developing and applying synergic methods and algorithms for investigating the water cycle, using remote sensing techniques. The focus is on the use of satellite data (optical and microwave) for monitoring vegetation cover and water status along with soil moisture temporal evolutions in order to improve the knowledge of the water cycle in arid areas. Both local and regional monitoring are carried out in order to investigate different spatial scales. The scope of the project is to propose practical and costeffective solutions for driving and updating a method for the sustainable use of water in agriculture. First results on soil moisture mapping retrieved in Tunisia using an Artificial Neural Network (ANN) based algorithm is presented in this pap

An autosomal recessive leucoencephalopathy with ischemic stroke, dysmorphic syndrome and retinitis pigmentosa maps to chromosome 17q24.2-25.3

Background Single-gene disorders related to ischemic stroke seem to be an important cause of stroke in young patients without known risk factors. To identify new genes responsible of such diseases, we studied a consanguineous Moroccan family with three affected individuals displaying hereditary leucoencephalopathy with ischemic stroke, dysmorphic syndrome and retinitis pigmentosa that appears to segregate in autosomal recessive pattern. Methods All family members underwent neurological and radiological examinations. A genome wide search was conducted in this family using the ABI PRISM linkage mapping set version 2.5 from Applied Biosystems. Six candidate genes within the region linked to the disease were screened for mutations by direct sequencing. Results Evidence of linkage was obtained on chromosome 17q24.2-25.3. Analysis of recombination events and LOD score calculation suggests linkage of the responsible gene in a genetic interval of 11 Mb located between D17S789 and D17S1806 with a maximal multipoint LOD score of 2.90. Sequencing of seven candidate genes in this locus, ATP5H, FDXR, SLC25A19, MCT8, CYGB, KCNJ16 and GRIN2C, identified three missense mutations in the FDXR gene which were also found in a homozygous state in three healthy controls, suggesting that these variants are not disease-causing mutations in the family. Conclusion A novel locus for leucoencephalopathy with ischemic stroke, dysmorphic syndrome and retinitis pigmentosa has been mapped to chromosome 17q24.2-25.3 in a consanguineous Moroccan family

SCROTAL ULCERATION FOLLOWING ALL-TRANS RETINOIC ACID THERAPY FOR ACUTE PROMYELOCYTIC LEUKEMIA

All-trans retinoic acid (ATRA) induces complete remission in most cases of acute promyelocytic leukemia. Toxicity of ATRA has been shown to be mild, consisting of headache, dry skin, dermatitis, and gastrointestinal disorders. We describe a case of scrotal ulceration with ATRA use in a Moroccan patient, an occurrence that has been rarely reported in the medical literature. The pathogenesis of scrotal ulceration remains unknown. Our experience indicates the importance of recognizing genital ulcers associated with ATRA in order that appropriate countermeasures can be taken

AMYLOSE CONJONCTIVALE: PREMIERE MANIFESTATION D’UNE AMYLOSE SYSTEMIQUE ASSOCIEE AU MYELOME MULTIPLE

IntroductionL’amylose systémique de type AL a été décrite dans presque tous les organes. Cependant l’atteinte conjonctivale est relativement rare et décrite le plus souvent sous forme de cas isolés et petites séries de cas. Elle est le plus souvent une manifestation de l’amylose oculaire localisée; toutefois, une atteinte palpébrale peut survenir dans le cadre d’une forme systémique. Nous rapportons l’observation d’une amylose AL, qui apparait originale par l’atteinte conjonctivale révélatrice en soulignant le retard diagnostic et thérapeutique du à la méconnaissance de cette localisation et les tentatives de traitement symptomatique.ObservationUn patient de 58 ans présentait un purpura palpébral, périorbitaire bilatéral en lunette et des masses conjonctivales avec notion d’hémorragies conjonctivales intermittentes. Cette symptomatologie évoluait depuis plus de 12 mois, ayant suscitée plusieurs consultations ophtalmologiques et dermatologiques, ainsi que divers traitements symptomatiques jusqu’à réalisation d’un bilan biologique objectivant un pic des gammaglobulines à l’électrophorèse des protéines sériques suivi de la réalisation d’une biopsie conjonctivale posant le diagnostic d’amylose et imposant une recherche extensive ayant retrouver d’autres localisations d’amylose associées au myélome multiple.Discussion/ Conclusion  L’amylose  conjonctivale est une affection rare, dont le diagnostic est suspecté cliniquement et confirmé par examen histopathologique. Elle peut être le seul signe révélateur d’une atteinte systémique et son diagnostic impose une recherche systémique d’autres localisations

Water management and climate change monitoring in Tunisia and Egypt using remote sensing techniques

This project deals with the implementation of an innovative water management system in Mediterranean countries (i.e. Tunisia and Egypt), which suffer from chronic water scarcity, together with two European countries (Germany and Italy). The consortium is developing and applying synergic methods and algorithms for investigating the water cycle, using remote sensing techniques. The focus is on the use of satellite data (both optical and microwave) for monitoring vegetation cover and water status along with soil moisture temporal evolutions in order to improve the knowledge of the water cycle in arid areas. Both local and regional monitoring are carried out in order to investigate different spatial scales. Environmental models and algorithms for the retrieval of hydrological parameters have been developed in the frame of this project in order to match the main goal of the project, i.e. to propose practical and cost-effective solutions for driving and updating a method for the sustainable use of water in agriculture. An optimized management of water resources for cultivated lands on Egyptian Delta (Northern part) and Tunisian territory will be realized by analyzing the available spatial and temporal data for the areas of interest appropriately selected for this purpose. As such, an efficient water use, equitable distribution of water resources, community participation in decisions, and sustainable system operation over time can be supported. First of all, we aim to localize different crop and irrigation techniques for the study regions. This information is required as a basis for further investigations and assessments. Secondly, the water efficiency for different lands, crop types and irrigation systems will be assessed. Afterwards, possible improvements in agricultural practice with respect to climate changescenarios and information on water efficiency will be determined by rating the outcome from the assessment